Plant Terpenoids in Cardioprotection: An Overview of Their Therapeutic Potential [0.03%]
植物萜类化合物在心血管保护中的作用及其治疗潜力概述
José L Ríos-López,José Blanco-Salas,Guadalupe Cumplido-Laso et al.
José L Ríos-López et al.
Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, making the search for new therapeutic strategies to prevent or mitigate cardiac damage mandatory. Essential oils, long used in traditional medicine, contain...
Exploring Hydroxytyrosol as a Promising Virucidal Agent: In Silico and In Vitro Insights into Enveloped Viruses [0.03%]
探索水合酪醇作为有前景的灭活病毒剂：针对包膜病毒的计算和实验研究见解
Hanan El Ouadi,Zineb Rhazzar,Barbara Poddesu et al.
Hanan El Ouadi et al.
The research investigates synthetic hydroxytyrosol (HT) antiviral properties against enveloped and non-enveloped viruses using in silico and in vitro methods. Molecular docking and ADMET analyses suggested favorable interactions of HT with ...
Comparative Whole Genome Analysis and Targeted Validation of Variants in Three Greek Indigenous Sheep Breeds [0.03%]
希腊三个地方绵羊品种的全基因组分析及目标变异验证
Maria-Anna Kyrgiafini,Georgios Stamatellos,Costas Stamatis et al.
Maria-Anna Kyrgiafini et al.
Indigenous sheep breeds represent valuable reservoirs of genetic diversity shaped by long-term adaptation to local environments and management systems. Greek autochthonous sheep breeds remain underrepresented in genomic and functional studi...
A Potent Single-Domain Antibody Targeting LAG-3 for Efficient Tumor Immunotherapy [0.03%]
一种高效的肿瘤免疫治疗抗LAG-3单结构域抗体疗法
Mengfei Dong,Wenjie Li,Tailin Wang et al.
Mengfei Dong et al.
Lymphocyte activation gene-3 (LAG-3) is a pivotal immune checkpoint receptor that exerts a negative regulatory effect on T-cell function. Although LAG-3-blocking antibodies have shown promising clinical potential, the inherent limitations o...
Cellular Origins and Context-Dependent Prognostic Effects of Lactate Metabolism Genes Reveal Novel Molecular Subtypes in Gastric Cancer [0.03%]
细胞起源和上下文依赖的乳酸代谢基因预后效应揭示胃癌中的新型分子亚型
Xiaoxuan Pan,Xin Chen,Chunyuan Zhang et al.
Xiaoxuan Pan et al.
Objective: Gastric cancer (GC) exhibits profound heterogeneity, yet the contribution of lactate metabolism reprogramming to this diversity and its cellular basis remain incompletely understood. This study aimed to dissect...
Artificial Intelligence for Spatial Immunometabolic Analysis of the Tumor Microenvironment: Current Evidence and Future Directions [0.03%]
肿瘤微环境空间免疫代谢分析的人工智能方法：现有证据及未来方向
Ismail Abdullah,Shady Saud Khan,Sariya Khan et al.
Ismail Abdullah et al.
The tumor microenvironment [TME] is a dynamic ecosystem where spatial organization and metabolic reprogramming play a crucial role in immune response, tumor progression, and therapeutic response. Recent breakthroughs in spatial transcriptom...
A Synthetic Lethality-Informed Multi-Omic Framework for Identifying a Five-Gene Diagnostic Signature in Chronic Obstructive Pulmonary Disease [0.03%]
一种合成致死性指导的多组学框架用于识别慢性阻塞性肺疾病五基因诊断标志物
Yue Yang,Zengrui Wang,Xiaorong Su et al.
Yue Yang et al.
Chronic obstructive pulmonary disease (COPD) lacks reliable molecular biomarkers for early diagnosis and risk stratification beyond conventional spirometry-based assessment. Synthetic lethality (SL)-related gene prioritization provides a bi...
Molecular Mechanisms of Plant Stress Tolerance: From Stress Perception to Phytohormonal Crosstalk and Transcriptional Regulation [0.03%]
植物逆境抗性分子机制研究从胁迫识别到植物激素互作及转录调控
Sajid Ali,Yong-Sun Moon
Sajid Ali
In recent years, plant stress biology has moved beyond single-pathway descriptions toward an integrated framework in which stress perception, hormonal control, and gene regulation are tightly interconnected. Early events such as membrane-as...
mTOR Inhibition Drives Mutation-Specific Remodeling of Lysosomal and Autophagic Pathways and GCase Activity in PBMC-Derived Macrophages from Patients with GBA1-Associated Parkinson's Disease [0.03%]
mTOR抑制可驱动GBA1相关帕金森病患者PBMC源性巨噬细胞中的突变特异性溶酶体和自噬通路重塑及GCase活性变化
Anastasia Bezrukova,Katerina Basharova,Anton Emelyanov et al.
Anastasia Bezrukova et al.
To date, we and others have demonstrated that GBA1-associated Parkinson's disease (GBA1-PD) exhibits hyperactivation of mTOR and impairment of mTOR-regulated autophagy. Our previous study showed that the degree of autophagy impairment depen...
Brucella Omp25c Modulates Host NAD+/NADH Homeostasis via Interaction with the Mitochondrial Complex I Assembly Factor Ndufaf2 [0.03%]
布鲁氏菌Omp25c通过与线粒体复合物I组装因子Ndufaf2相互作用来调控宿主NAD+/NADH稳态
Lina Wang,Lian Wu,Kexin Zhang et al.
Lina Wang et al.
Brucellosis, acting as a typical chronic zoonotic disease, is caused by the invasion of Brucella into the human body. Outer membrane protein 25 (Omp25), specifically localized on the Brucella membrane, is the main virulence factor of Brucel...