Genetic and Epigenetic Mechanisms in Serrated Adenocarcinomas and Classical Colorectal Carcinomas: An In Silico Study [0.03%]
遗传和表观遗传机制在锯齿状腺癌与经典结直肠癌中的差异：一项基于计算的研究
Zeynep Sagnak Yilmaz,Sibel Demir Kececi,Ozgul Sagol et al.
Zeynep Sagnak Yilmaz et al.
Serrated adenocarcinoma (SAC) represents a molecularly heterogeneous subtype of colorectal carcinoma (CRC) linked to the serrated pathway. It is aimed to clarify the molecular mechanisms underlying SAC development. Digital slides from The C...
From Adipose Dysfunction to Multi-Organ Steatosis: Defining the Metabolic Steatotic Axis [0.03%]
从脂肪组织功能障碍到多器官脂变：代谢性脂变轴的定义
Almir Fajkić,Yun Wah Lam,Rijad Jahić et al.
Almir Fajkić et al.
Steatosis extends beyond the liver to the pancreas, heart, and skeletal muscle, yet prevailing definitions remain narrowly organ-focused. This narrative review introduces the Metabolic Steatotic Axis (MSA) as a framework that captures the d...
Simultaneous Inhibition of MDM2 and XIAP by MX69 Induced Cell Cycle Arrest and Apoptosis in HUH7 and Hep3B Cell Lines [0.03%]
MX69通过同时抑制MDM2和XIAP诱导HUH7和Hep3B细胞系生长停滞和凋亡
Can Ali Ağca
Can Ali Ağca
Genomic instability not only drives tumor initiation and progression but also cooperates with apoptosis resistance to promote therapeutic evasion in hepatocellular carcinoma (HCC). Activation of MDM2, a negative regulator of p53, together w...
Network Pharmacology-Based Analysis Reveals the Mechanisms of the Tibetan Medicinal Plant Meconopsis quintuplinervia Against COPD and NAFLD: Insights from LC-MS/MS Profiling and Antioxidant/Anti-Inflammatory Activities [0.03%]
基于网络药理学的分析揭示了藏药Meconopsis quintuplinervia对抗COPD和NAFLD的机制：来自LC-MS/MS分析和抗氧化/抗炎活性的启示
Fangfang Chen,Mingjing Chen,Yiyu Chen et al.
Fangfang Chen et al.
Meconopsis quintuplinervia is traditionally used in Tibetan medicine for diseases of the lung and liver. This study investigated the antioxidant and anti-inflammatory activities of its extract (MQ extract), analyzed its chemical composition...
Sympathetic Chain Ganglia in the Female Pig During Prenatal Development: Noradrenergic and Cholinergic Neurons [0.03%]
雌性猪在 prenatal development 中的 sympathetic chain ganglia：Noradrenergic 和 cholinergic 神经元
Amelia Franke-Radowiecka
Amelia Franke-Radowiecka
Due to the limited data on chemical coding of sympathetic chain ganglia neurons during the prenatal period, this study, for the first time, aimed to characterise noradrenergic and cholinergic neurotransmitter expression in lumbar sympatheti...
Plasma-Derived Extracellular Vesicles Inhibit Lipopolysaccharide-Induced Apoptosis and Oxidative Stress in Human AC16 Cardiomyocytes [0.03%]
血浆源性外泌体通过抑制氧化应激及细胞凋亡对LPS诱导的人类AC16心肌细胞损伤的保护作用研究
Yuli Yang,Tingting Yang,Zhihong Li et al.
Yuli Yang et al.
Sepsis is frequently accompanied by myocardial dysfunction, which significantly worsens clinical outcomes. Lipopolysaccharide (LPS), a key component of Gram-negative bacteria, induces excessive oxidative stress and apoptosis in cardiomyocyt...
Genetic Variation in the Main Cultivar Collection of Castanea henryi Revealed by Genome Resequencing [0.03%]
栗叶柯主要栽培品种群体重测序基因组变异分析
Yifan Wang,Xueting Yuan,Jinhui Yang et al.
Yifan Wang et al.
Castanea henryi is an important economic tree species in China. Its nutrient-rich nuts play a key role in raising farmers' income in mountainous areas, promoting forestry industry development, and maintaining ecological balance, thereby pro...
Plant-Derived Secondary Metabolites Modulating Inflammation-Driven Pathways in Hepatocellular Carcinoma: Preclinical Insights [0.03%]
植物衍生次生代谢产物调节肝细胞癌炎症驱动途径的临床前见解
Sergio Arael Mendoza-Calderón,Holanda Isabel Cruz Luis,Laura Pérez-Campos Mayoral et al.
Sergio Arael Mendoza-Calderón et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, primarily driven by chronic inflammation from viral hepatitis, metabolic dysfunction, alcohol-induced liver disease, and cirrhosis. Conventional therap...
Hatice Esenkaya,Joe Bryant
Hatice Esenkaya
Post-transcriptional regulation of gene expression is influenced by RNA-binding proteins (RBPs) and small non-coding RNAs that bind to conserved mRNA sequences to modulate mRNA processing. These regulatory molecules affect the structural co...
Botanical Adjuvants in Oncology: A Review on Natural Compounds in Synergy with Conventional Therapies as Next-Generation Enhancers of Breast Cancer Treatment [0.03%]
肿瘤学中的植物辅助剂：协同作用于传统疗法的天然化合物作为下一代乳腺癌治疗增强剂综述
Hidaya Mansouri,Ahmed Irchad,Clarence Rubaka et al.
Hidaya Mansouri et al.
Breast cancer remains a major global health challenge despite advances in chemotherapy, endocrine therapy, targeted therapy, and radiotherapy, which are frequently constrained by therapeutic resistance, cumulative toxicity, and high costs. ...