Transcriptomic Profiling Identifies Potential Prognostic Genes in Vietnamese Patients with Non-Small-Cell Lung Cancer [0.03%]
转录组分析鉴定出越南非小细胞肺癌患者中的潜在预后基因
Tuan Quoc Bach,Giang Thi Chau Truong,Bang Ngoc Dao et al.
Tuan Quoc Bach et al.
Background/objectives: Non-small-cell lung cancer (NSCLC) is one of the most common malignancies in Vietnam, yet its molecular mechanisms remain incompletely understood. This study aimed to identify prognostic genes in Vi...
Cytotoxic and Antimelanoma Activity of Selected 3-Methyl-1,6-diazaphenothiazines in Human Melanoma Cells-In Vitro Studies [0.03%]
3-甲基-1,6-二氮菲噻唑化合物的细胞毒性和抗黑色素瘤活性：体外研究
Beata Morak-Młodawska,Małgorzata Jeleń,Zuzanna Rzepka et al.
Beata Morak-Młodawska et al.
The cytotoxic and mechanistic effects of novel 10-substituted 3-methyl-1,6-diazaphenothiazines were investigated in human melanoma models. Antiproliferative activity was evaluated in vitro using the WST-1 assay in four melanoma cell lines (...
Natural Products Targeting Acetylation in Bladder Cancer: Mechanistic Basis, Therapeutic Potential, and Future Perspectives [0.03%]
天然产物在膀胱癌乙酰化靶向中的作用：机制基础、治疗潜力和未来前景
Wei Li,Da Liu,Qinzhamusu Yin et al.
Wei Li et al.
Bladder cancer remains a major clinical challenge because of its high recurrence rate, marked molecular heterogeneity, frequent progression, and limited durability of current therapeutic strategies. Increasing evidence indicates that acetyl...
The Potential and Prospects of Hydrogel Applications in Traumatic Brain Injury Treatment [0.03%]
水凝胶在创伤性脑损伤治疗中的潜力与前景
Cheng Zhong,Jie Li,Dengzhuo Liu et al.
Cheng Zhong et al.
Traumatic brain injury (TBI) is a prevalent neurological disorder that induces severe neurological dysfunction and markedly reduces quality of life owing to its complex pathophysiology and limited therapeutic options. Conventional pharmacol...
Coix Seed Oil Ameliorates Rheumatoid Arthritis by Modulating Inflammation-Associated Metabolic Pathways [0.03%]
薏仁油通过调节与炎症相关的代谢途径改善类风湿性关节炎
Yong Yang,Ying Feng,Weijie Tang et al.
Yong Yang et al.
Rheumatoid arthritis (RA) is a chronic disease that primarily manifests as symmetrical joint inflammation. Although Coix Seed Oil (CSO) has demonstrated anti-inflammatory effects in RA rat models, its systemic metabolic regulatory mechanism...
NEK1 Promotes Ovarian Cancer Progression via p53 Suppression While Enhancing Sensitivity to Genotoxic Therapy [0.03%]
NEK1通过抑制p53促进卵巢癌进展并增强其对基因毒性治疗的敏感性
Huiyang Song,Xia Wang,Aiqing Yang et al.
Huiyang Song et al.
Ovarian cancer (OV) is a highly metastatic and recurrent malignancy with limited therapeutic options. NIMA-related kinase 1 (NEK1), a serine/threonine kinase implicated in cell cycle regulation and DNA damage response, has been associated w...
MEOX1 Inhibits Growth and Metastasis of Salivary Adenoid Cystic Carcinoma [0.03%]
MEOX1抑制涎腺腺样囊性癌的生长和转移
Huaxiu Sun,Yuping Liu,Yajuan Cui et al.
Huaxiu Sun et al.
Salivary adenoid cystic carcinoma (SACC) is a malignant salivary gland neoplasm characterized by aggressive local invasion and a marked propensity for metastasis. However, the role of MEOX1 in SACC progression remains poorly defined. In thi...
The Mechanisms of Changes in Storage Substances and Hormone Levels During Artificial Aging of Different Varieties of Perilla [0.03%]
不同品种紫苏人工贮藏过程中储藏物质及激素水平变化机制
Yang Hang,Jinwei Pan,Xiang Yi et al.
Yang Hang et al.
Seed aging is a key issue that affects the preservation of germplasm resources and crop production. At present, the anti-aging properties of perilla seeds and the mechanisms of differences among varieties have not been clearly reported. Thi...
Natural Products in Epilepsy Treatment: From Traditional Medicine Towards Computational Drug Discovery [0.03%]
癫痫治疗中的天然产物研究：从传统医学到计算药物发现
Muhammad Yasir,Jin-Hee Han,Jongseon Choe et al.
Muhammad Yasir et al.
Epilepsy affects approximately 50 million people worldwide, with nearly one-third of patients experiencing drug-resistant seizures despite available antiepileptic drugs (AEDs). Natural products remain an important source of bioactive scaffo...
Impact of a Single Hemodialysis Session on Oxidative Stress-Inducing and Oxidative Damage Biomarkers in End-Stage Kidney Disease Patients [0.03%]
单次血液透析对终末期肾脏病患者氧化应激诱导标志物和氧化损伤生物标志物的影响
Athina Varemmenou,Effimia Michail,Electra Kalaitzopoulou et al.
Athina Varemmenou et al.
Oxidative stress (OS) is elevated in patients with end-stage kidney disease undergoing maintenance dialysis and contributes to increased cardiovascular risk. While kidney dysfunction and dialysis can generate OS, the acute effects of a sing...