Modulation of Corticotropin-Releasing Hormone Receptor Expression During In Vitro Keratinocyte Differentiation [0.03%]
促肾上腺皮质激素释放激素受体在体外角质形成细胞分化过程中的表达调控
Carole-Anne Martins,Sara Lesink,Angéline Roux et al.
Carole-Anne Martins et al.
Corticotropin-releasing hormone (CRH) and its receptors CRHR1 and CRHR2 are major actors in the stress response and are well established as components of the hypothalamic-pituitary-adrenal (HPA) axis. Evidence also suggests they are express...
Transcriptome Analysis of Drought Resistance in Japanese Lawn Grass (Zoysia japonica Steud.) [0.03%]
日本结缕草耐旱性转录组分析
Ruijia Zhao,Lei Xu,Xinzi Wang et al.
Ruijia Zhao et al.
With the intensification of global climate change, the increasing frequency and severity of extreme weather events seriously affected agroecosystems and human health. Zoysia japonica Steud. (Z. japonica) is a warm season turfgrass with outs...
Comparison of ABQ-48 Multimodal Cytotoxicity Mechanism Against Lung, Colorectal, and Breast Cancer Cells [0.03%]
ABQ-48多模态细胞毒机制对肺癌、结直肠癌和乳腺癌细胞的作用比较
Sebastián A Rosario-Torres,Mayra Luciano-Torres,Alondra Alonso-Sevilla et al.
Sebastián A Rosario-Torres et al.
Cancer continues to be a significant cause of death worldwide, particularly cancers with high incidence and mortality such as colorectal, breast, and lung, motivating the continued search for novel anticancer agents. Among potential new mol...
Rhus coriaria Linn Extract as a Natural Inhibitor of Influenza A Virus Replication In Vitro [0.03%]
牻牛儿苗提取物体外抑制流感病毒复制研究
Carla Prezioso,Maria Luisa Savo Sardaro,Flavio Frezza et al.
Carla Prezioso et al.
Influenza A viruses remain a major public health threat due to their high mutation rates, antigenic variability, and the emergence of resistance to current antivirals, underscoring the need for novel therapeutic options. Natural compounds r...
Measles: An Updated Literature Review of the Host Response, Pathogenesis, Complications, Prevention Measures, and Recent Outbreaks [0.03%]
麻疹：宿主反应、发病机制、并发症、预防措施及最近疫情的文献回顾
Stefanie Au,Seema Saini,William Dela Cruz et al.
Stefanie Au et al.
Measles remains a significant global health threat due to its extreme transmissibility and the potential for severe, long-term complications. This review synthesizes the most up-to-date literature on the host response, immunological impact,...
ABCC Gene Variants and Their Effects on Non-Response and Relapse in Pediatric Patients with Central Nervous System Tumors: A Cohort Study [0.03%]
ABCC基因变异及其对中枢神经系统肿瘤患儿无应答和复发的影响：队列研究
Luz María Torres-Espíndola,Juan Carlos Pérez-De Marcos,Manuel de Jesús Castillejos-López et al.
Luz María Torres-Espíndola et al.
The variability in outcomes among individuals is caused by multiple factors, including genetic variations in drug transporter genes known as ABCs. This study investigates the clinical effect of single-nucleotide variants (SNVs) in the ABCC1...
In Silico Molecular Docking and Pharmacokinetic Evaluation of Cannabinoid Derivatives as Multi-Target Inhibitors for EGFR, VEGFR-1, and VEGFR-2 Proteins [0.03%]
大麻素衍生物作为表皮生长因子受体和血管内皮生长因子受体的多靶标抑制剂的分子对接及药代动力学评估
Akhtar Ayoobi,Hyong Woo Choi
Akhtar Ayoobi
Cancer therapy development increasingly focuses on multi-target approaches to inhibit key proteins involved in tumor growth and angiogenesis. This study explored the potential inhibitory interactions of 110 cannabinoid derivatives using mol...
Influence of Different Death Receptor Signaling Pathways on Apoptosis of Eimeria tenella Host Cells [0.03%]
不同死亡受体信号通路对艾美耳球虫宿主细胞凋亡的影响研究
Zhiyong Xu,Xuanyao Yu,Jinyou Ma et al.
Zhiyong Xu et al.
The aim of this study was to investigate the regulatory roles of distinct signaling cascades within the death receptor pathway in host cell apoptosis induced by Eimeria tenella (E. tenella); to this end, primary chicken embryo cecal epithel...
Shuai Li,Chenxia Gao,Hongyu Zhao et al.
Shuai Li et al.
Immune response evasion is one of the hallmark features of cancer, which is not only the basis for cancer progression and metastasis but also affects the clinical management of cancer. Tumor immune evasion is mainly attributed to the dynami...
Diet-Induced Browning of White Adipose Tissue: Molecular Targets, Mechanisms, and Therapeutic Potential [0.03%]
饮食诱导的白色脂肪组织褐变：分子靶点、机制和治疗潜力
Zhi-Da Yang,Jia-Wei Chen,Ying-Xiu Mei et al.
Zhi-Da Yang et al.
Obesity, driven by chronic energy imbalance, has become a major global health burden and is strongly associated with metabolic disorders, including diabetes, hypertension, and cardiovascular disease. Conventional pharmacotherapies often exh...