Next-Generation Sequencing for Minimal Residual Disease Detection in Pediatric Acute Lymphoblastic Leukemia: Technological Advances, Clinical Translations and Current Challenges [0.03%]
下一代测序在儿童急性淋巴细胞白血病微小残留病检测中的技术进步、临床转化和当前挑战
Nan Liu,Yi Zheng,Xiaojun Xu
Nan Liu
Minimal residual disease (MRD) is the most robust independent prognostic biomarker for pediatric acute lymphoblastic leukemia (ALL). Conventional MRD detection assays suffer from insufficient sensitivity and inherent technical limitations, ...
Coreopsistinctoria Nutt. Alleviates Intestinal Barrier Damage in Slow Transit Constipation Through the PI3K/AKT Pathway [0.03%]
刺儿菜素通过PI3K / AKT信号通路改善慢传输型便秘患者的肠屏障损害作用
Guliziremu Ainiwaer,Xiaoxuan Zhang,Mukatansi Tayier et al.
Guliziremu Ainiwaer et al.
Background: The development of Slow Transit Constipation (STC) is associated with intestinal barrier damage. Coreopsis tinctoria Nutt. (CT) is effective in treating STC, but the mechanisms are unclear. Methods: We investigated three CT extr...
Imperfect Maturation of Erythroid Progenitors in Patients with Cirrhosis-Associated Anemia [0.03%]
肝硬化相关性贫血患者红系祖细胞成熟异常
Deepika Lal,Jaswinder Singh Maras,Rakhi Maiwall et al.
Deepika Lal et al.
Background and Aims: Anemia is seen in nearly >70% of patients with cirrhosis and is often non-responsive to nutritional supplements; therefore, we assessed the erythropoiesis and associated alteration in bone marrow (BM). Methods: It is a ...
Maize Aldehyde Decarbonylase 1 Gene (ZmCER1) Positively Regulates Salt and Drought Tolerance by Improving Wax Synthesis and Reactive Oxygen Species Detoxification [0.03%]
ZmCER1通过改善蜡质合成和活性氧清除过程正向调控耐盐性和抗旱性
Yaqing Yang,Mingzi Shi,Yaxin Liu et al.
Yaqing Yang et al.
Maize (Zea mays L.) is a vital global crop whose productivity is severely threatened by abiotic stresses. Epicuticular waxes provide a hydrophobic barrier that protects land plants from environmental stresses. However, the role of key wax b...
Etiology Model of Kawasaki Disease and Multisystem Inflammatory Syndromes: Mast Cell Activation [0.03%]
川崎病和多系统炎症综合征的病因模型： mast细胞活化
Darrell O Ricke
Darrell O Ricke
Background/objectives: Kawasaki's disease (KD) is a leading cause of heart disease in children. The multisystem inflammatory syndrome (MIS) associated with the SARS-CoV-2 virus is similar to KD. The etiologies of KD and M...
Phenolic-Enriched Fractions of Rubus buergeri Attenuate LPS-Induced Nitric Oxide Production and Inflammatory Gene Expression in Macrophages [0.03%]
Rubus buergeri富含酚类组分通过抑制脂多糖诱导的巨噬细胞炎症反应中的NO生成及促炎因子表达而发挥抗炎作用
Theophilus Bhatti,Hong-Yi Xiang,Jihyun Lee et al.
Theophilus Bhatti et al.
Rubus buergeri Miq., a wild species native to Jeju Island (Republic of Korea), is a relatively understudied plant with potential as a source of bioactive phenolic compounds. This study investigated the phytochemical composition of R. buerge...
Association of Vitamin D Receptor Gene Polymorphisms and Hypovitaminosis D with Reduced Bone Mineral Density in Survivors of Childhood Leukemia: A Study in Algerian Patients [0.03%]
维A酸D受体基因多态性和维生素D缺乏与儿童期白血病幸存者骨密度降低的关系：阿尔及利亚患者的病例研究报告
Wafa Khelaifia,Ines Gouaref,Fatma Zohra Djaballah-Ider et al.
Wafa Khelaifia et al.
Survivors of childhood leukemia are at increased risk of long-term skeletal complications, including reduced bone mineral density (BMD). Vitamin D deficiency and genetic variations in the vitamin D receptor (VDR) gene are important factors ...
Genomic Analysis Highlights the Misinterpretation of Acquired Aminoglycoside Resistance Genes in Deinococcus radiodurans [0.03%]
基因组分析揭示了放射耐受菌中获得性氨基糖苷类抗性基因的误读现象
Gabriel Augusto Marques Rossi,Fábio Parra Sellera,Eliana Guedes Stehling et al.
Gabriel Augusto Marques Rossi et al.
Aminoglycoside resistance is commonly mediated by enzymatic modification, target alteration, or efflux mechanisms; however, acquired resistance has not been characterized in radiation-resistant Deinococcus species. Here, we investigated the...
Phytochemical Analysis, GC-MS Chemical Profiling, and In Vitro Antidiabetic Evaluation of South African Momordica balsamina Linn Leaf Extracts and Its Effects on Oxidative Stress Modulation [0.03%]
南非巴沙麻籽叶提取物的植物化学分析、GC-MS化学谱图及体外抗糖尿病评价及其对氧化应激调节的影响
Buang Matseke,Daniel Tswaledi,Kokoette Bassey
Buang Matseke
Background: Momordica balsamina L. is widely used in traditional medicine for the management of diabetes in South Africa and globally. This study evaluated the in vitro antidiabetic and cytotoxic effects of M. balsamina l...
Sodium Butyrate Attenuates Isoprenaline-Induced Myocardial Injury via Restoring the Gut-Heart Axis and Suppressing TLR4/NF-κB Signaling [0.03%]
丁酸钠通过恢复肠心轴并抑制TLR4/NF-κB信号通路来缓解异丙肾上腺素诱导的心肌损伤
Hazrat Bilal,Imran Khan,Ayesha Yaseen et al.
Hazrat Bilal et al.
The gut-heart axis plays a role in cardiac injury due to the disruption of barriers, endotoxemia, and inflammatory signaling; yet, it is not clear whether sodium butyrate (SB) is capable of alleviating isoprenaline-induced myocardial injury...