Exploring the Effects and Mechanisms of Neohesperidin Dihydrochalcone on Acute Lung Injury in Mice with Sepsis Using Network Pharmacology and Machine Learning [0.03%]
网络药理学和机器学习在诺随索丁二氢查尔酮改善脓毒症小鼠急性肺损伤的作用及机制研究
Meijun Liu,Ting Li,Xue Dai et al.
Meijun Liu et al.
Neohesperidin dihydrochalcone (NHDC) is a synthetic sweetener derived from neohesperidin and can improve pathological changes in sepsis-associated acute lung injury (SALI), but the mechanism by which NHDC inhibits SALI remains unclear. We e...
Yiqiong Zhang,Qinghua Yao
Yiqiong Zhang
Cancer is one of the major lethal diseases in the world, and Western medicine treatments are often affected by side effects and drug resistance. Ginseng is a commonly used Chinese medicine in clinical practice, and Ginsenoside Rh1, an impor...
Feline Alimentary Lymphomas: Established Concepts and an Underexplored Molecular Landscape [0.03%]
猫胃肠淋巴瘤：已建立的概念和有待探索的分子特征
Laura A Szafron,Maciej Parys,Magdalena Parys et al.
Laura A Szafron et al.
Domestic cats are among the most popular companion animals worldwide, with steadily increasing ownership and life expectancy. Paradoxically, despite their high prevalence and shared environmental exposures with humans, cats remain markedly ...
Comparative Analysis of Methodological Aspects of the Study of Extracellular Vesicles and Extracellular Mitochondria: From Isolation to Internalization [0.03%]
外泌体和胞外线粒体研究方法学方面的比较分析：从分离到内吞
Natalia Yunusova,Dmitry Svarovsky,Evgenya Kaigorodova et al.
Natalia Yunusova et al.
Mitochondrial transfer in mammals has been proven to occur both under physiological conditions and during pathological conditions. It has been shown that neighboring cells can exchange mitochondria via nanotunnel tubes. However, there is ev...
Benjamin S Buehrer,Adam R Grden,Ethan Johnson et al.
Benjamin S Buehrer et al.
Multiple Myeloma is a malignancy of the plasma cells of the bone marrow. This cancer rapidly becomes refractory to many of the currently available chemotherapeutic regimens used against it, requiring an alternative option or supplementary t...
Scissor-CIBERSORTx Deconvolution Reveals Functional Heterogeneity of CTAL/aTAL Cells and Associated Biomarkers in Renal Fibrosis [0.03%]
基于剪切的CIBERSORTx去卷积揭示肾纤维化中CTAL/aTAL细胞的功能异质性及其相关生物标志物
Hengping Wang,Yuan Zhang,Jiale Li et al.
Hengping Wang et al.
Renal fibrosis (RF) represents a major pathological outcome of chronic kidney disease, currently accompanied by extremely limited therapeutic strategies. To decipher key cellular and molecular drivers, we integrated single-cell and bulk tra...
Elucidating the PTK2-Targeted Anti-Hepatocellular Carcinoma Effects of Euphorbia helioscopia L. via Integrated Network Pharmacology, Mendelian Randomization, and Experimental Validation [0.03%]
基于整合网络药理学、孟德尔随机化和实验验证的紫茉莉抗肝癌PTK2靶点作用机制研究
Jianhua Zhu,Li Qian,Chuanjun Yuan et al.
Jianhua Zhu et al.
Euphorbia helioscopia L. (Zeqi, ZQ) is a traditional Chinese herb used to treat various tumors, but its molecular mechanisms against hepatocellular carcinoma (HCC) remain unclear. This study aims to elucidate the anti-HCC mechanisms of ZQ u...
Phytochemical Quorum-Sensing Inhibitors Against Bacterial Pathogens: Mechanisms of Action and Translational Challenges [0.03%]
植物化学类准.quorum sensing抑制剂对抗细菌病原体的作用机制及转化挑战
Christos Papaneophytou
Christos Papaneophytou
Antimicrobial resistance is a critical global health challenge, driven by the rapid emergence of multidrug-resistant bacterial pathogens and exacerbated by extensive antibiotic use, which imposes intense selective pressure and disrupts host...
Propolis Attenuates Cisplatin-Induced Ovarian Injury by Modulating Oxidative Stress, Inflammation, Apoptosis, and GRP78/ATF6/CHOP Pathway [0.03%]
propolis通过调节氧化应激、炎症、 apoptosis 和grp78/atf6/chop途径来缓解顺铂诱导的卵巢损伤
Bakiye Akbaş,Şeyda Kanbolat,Merve Badem et al.
Bakiye Akbaş et al.
Cisplatin-induced ovarian damage is a significant concern for young women receiving chemotherapy. Although propolis, a polyphenol- and flavonoid-rich natural product, has been proposed as a protective agent, its effects on cisplatin-related...
Self-Assembled Hydrogels: A Novel Drug Delivery System for Osteoarthritis [0.03%]
一种治疗骨关节炎的新型药物递送系统：自主装水凝胶
Hongjuan Wen,Xintong Gu,Kuo Wen et al.
Hongjuan Wen et al.
Osteoarthritis (OA) is a prevalent degenerative disease of the musculoskeletal system worldwide. Self-assembled hydrogels, as a novel drug delivery system, have demonstrated significant advantages in the treatment of OA. Through non-covalen...