AI and Machine Learning for Proteomics-Driven Drug Discovery: Methods, Tools, and Best Practices [0.03%]
基于蛋白质组学的药物发现中的AI与机器学习：方法、工具及最佳实践
Suman Basak
Suman Basak
Proteomics has become central to pharmacological research by providing quantitative readouts of protein abundance, post-translational modifications, interactions, and spatial context. However, proteomic datasets are high-dimensional, hetero...
Screening the Combination of Gemcitabine, Clomipramine, and Resveratrol in HL-60 Leukemia Cells [0.03%]
吉西他滨、氯米帕明和白藜芦醇联合筛选HL-60白血病细胞
Burcu Biltekin,Yusuf Elgormus,Ayhan Bilir
Burcu Biltekin
Background and Objectives: Potential anti-neoplastic effects of resveratrol, which has antioxidant features combined with clomipramine, which has antineoplastic features, or with gemcitabine, used as a nucleoside analog widely used in chemo...
Yanshi Hu,Zixuan Wang,Yueming Hu et al.
Yanshi Hu et al.
Transcriptomic meta-analysis enhances biological veracity and reproducibility of differentially expressed genes (DEGs) by integrating multiple independent studies, yet prevailing p-value or effect-size integration approaches exhibit limited...
How Polyphenol Metabolites Spatiotemporally Reprogram Transcription Factors and Human Proteostasis: A Metabolite-Centric Framework [0.03%]
时空多酚代谢物重新编程转录因子和人类蛋白质稳态的机制：以代谢物为中心的研究框架
José Manuel Pérez de la Lastra,Celia María Curieses Andrés,Elena Bustamante Munguira et al.
José Manuel Pérez de la Lastra et al.
Polyphenols act in humans through authentic metabolites, including regio-isomeric glucuronides/sulphates, O-methylated forms, and microbiota products (urolithins, γ-valerolactones, equol), that reach targets by spatiotemporally gated expos...
Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways [0.03%]
子宫内膜异位症中的激素失调与神经炎症：可药用通路的汇聚点
Ioana-Laura Olteanu,Ciprian Pușcașu,Corina Andrei et al.
Ioana-Laura Olteanu et al.
Endometriosis is a chronic, estrogen-dependent disorder defined by ectopic endometrial-like tissue growth, persistent inflammation, and aberrant innervation. Emerging evidence indicates that disease progression and symptom severity are driv...
In Silico Analysis of Polycyclic Aromatic Hydrocarbon (PAH) Degrader from Bordetella petrii Strain P003 Isolated from Contaminated Oil of Kuwait [0.03%]
从科威特受污染的石油中分离出来的伯氏波士顿杆菌P003菌株的多环芳烃(PAH)降解剂的计算机分析
Abrar Akbar,Rita Rahmeh,Mohamed Kishk et al.
Abrar Akbar et al.
Bordetella petrii is an environmentally versatile Gram-negative bacterium with hydrocarbon-degrading capabilities, yet its genetic and metabolic characteristics remain poorly characterized. This study investigated the genomic features of a ...
Reduced CAG Repeats in the Androgen Receptor Gene May Independently Cause Polycystic Ovarian Syndrome [0.03%]
雄激素受体基因中减少的CAG重复序列可能独立引起多囊卵巢综合征
Rhea Sharma,Daniel H Shain
Rhea Sharma
Polycystic ovarian syndrome (PCOS) affects over 116 million women globally and is typically linked with excess androgens such as testosterone. Many patients, however, display classic PCOS symptoms despite normal serum androgen. One proposed...
Elevated Tumor HIF-1α Expression Correlates with Advanced Pathological Stage Following Neoadjuvant Concurrent Chemoradiotherapy in Esophageal Squamous Cell Carcinoma [0.03%]
术前同期放化疗后食管鳞癌病理分期晚期内源性肿瘤HIF-1α高表达及其临床意义
Hsin-Yi Shih,Chien-Chih Chen
Hsin-Yi Shih
Tumor hypoxia has been implicated in treatment resistance and disease progression in esophageal squamous cell carcinoma (ESCC), yet its relationship with post-neoadjuvant pathological staging remains unclear. This study evaluated the associ...
Semaglutide Induces Oxidative Stress and Differentially Modulates mTOR-Dependent Growth and Invasion in Human Trophoblast Cell Models: Implications for Placental Function [0.03%]
司美格鲁肽诱导氧化应激并差异调节人胎盘细胞模型中mTOR依赖性生长和侵袭：对胎盘功能的影响
Elizabeth Thurmond,Eliza J Roeth,Kristen Noyes et al.
Elizabeth Thurmond et al.
Semaglutide, a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA), has transformed obesity and diabetes management. However, its expanding use among reproductive-age women raises concerns about potential effects on early placent...
Host-Induced Gene Silencing of SmDSR32 Enhances Wheat Defense Against Sitobion miscanthi [0.03%]
宿主诱导的基因沉默抑制SmDSR32以增强小麦对玉米黄蚜的抗性
Jiahui Zhang,Xue Zhong,Mingxin Cao et al.
Jiahui Zhang et al.
The grain aphid, Sitobion miscanthi, poses a serious threat to cereal crops worldwide, leading to considerable yield losses and demanding annual insecticide applications during the grain-filling stage. As a sustainable alternative, we explo...