Integrated Metabolomic and Transcriptomic Analysis of Phenylpropanoid Biosynthesis in Silphium perfoliatum [0.03%]
Silphium perfoliatum苯丙烷生物合成的代谢组学和转录组学综合分析
Guoying Zhang,Dejun Zhang
Guoying Zhang
Silphium perfoliatum is a promising economic plant rich in bioactive secondary metabolites, yet the molecular regulation of phenylpropanoid biosynthesis across development remains unclear. To elucidate the regulatory networks underlying the...
Evaluation of mTOR, NFκB, and BCL-2 Inhibitor Activity In Vitro on Diffuse Large B-Cell Lymphoma Cells [0.03%]
mTOR、NFκB和BCL-2抑制剂对弥漫性大B细胞淋巴瘤细胞的体外活性评估
Agata Majchrzak,Sylwia Mańka,Barbara Cebula-Obrzut et al.
Agata Majchrzak et al.
DLBCLs constitute an aggressive type of lymphoma with varied clinical, molecular and genetic features. The cells are characterized by NFkB pathway disturbances and BCL-2 and mTOR protein deregulation, which significantly inhibit apoptosis. ...
Admission Serum Inflammatory and Injury Biomarkers Are Associated with In-Hospital Mortality in Neurological Inpatients with Confirmed SARS-CoV-2 Infection: The Brain-COVID Cohort Study [0.03%]
脑冠状动脉疾病队列研究中确诊的SARS-CoV-2感染的神经系统住院患者的入院血清炎症和损伤生物标志物与住院死亡率相关
Justyna Zielińska-Turek,Wojciech Czyżewski,Grzegorz Turek et al.
Justyna Zielińska-Turek et al.
Patients hospitalized with neurological disorders may be at increased risk of adverse outcomes when infected with SARS-CoV-2. We evaluated whether early routine serum inflammatory and injury markers obtained at hospital admission are associ...
IL-37 Ameliorates Chronic Endometritis by Attenuating Epithelial-Mesenchymal Transition and Promoting M2 Macrophage Polarization [0.03%]
白细胞介素37通过抑制上皮间质转化和促进M2型巨噬细胞极化治疗慢性子宫内膜炎
Zihan Wang,Jiaxi Tan,Rui Zhang et al.
Zihan Wang et al.
Interleukin-37 (IL-37) is an anti-inflammatory cytokine with an undefined role in chronic endometritis (CE). This study aims to explore its therapeutic mechanism in CE, focusing on epithelial-mesenchymal transition (EMT) and macrophage pola...
Low KIF26B Expression Reduces Paclitaxel Resistance and Predicts Good Prognosis in Ovarian Cancer [0.03%]
KIF26B低表达降低卵巢癌紫杉醇耐药并预示良好预后
Yuting Su,Xia Liu,Yue Yu et al.
Yuting Su et al.
Ovarian cancer, the most lethal type of tumour of the female reproductive system, severely threatens women's life and health. Despite paclitaxel being a key chemotherapeutic agent in the standard treatment for ovarian cancer, the majority o...
Integrated Metabolomics and Targeted Gene Expression Profiling Reveal the Arginine-Anthocyanin Axis in Pomegranate Aril Paleness Disorder [0.03%]
整合代谢组学和靶向基因表达谱分析揭示了石榴瓤返白病的精氨酸-花青素轴作用机制
Mehdi Rezaei,Parviz Heidari,Stefanie Reim
Mehdi Rezaei
Aril paleness (AP) is a new physiological disorder of pomegranate (Punica granatum L.) characterized by pale, dry and tasteless arils, while the peel remains healthy-looking. Its molecular basis is unknown. We used an integrated metabolomic...
Bioconverted Blueberry Extract Potentiates the Angiogenic and Endothelial Functions in Human Dermal Microvascular Endothelial Cells Under Oxidative Stress [0.03%]
发酵蓝莓提取物可增强氧化应激下人真皮微血管内皮细胞的促血管生成和内皮功能
Jung Un Shin,Yun Hoo Jo,Soo Ah Jeong et al.
Jung Un Shin et al.
Endothelial dysfunction induced by oxidative stress is a critical contributor to impaired microvascular homeostasis and skin aging. Blueberries are rich in polyphenolic compounds with antioxidant properties. However, whether bioconversion e...
MicroRNA-451 Modulates Autophagy-Related Signaling with Relevance to Renal Fibrosis in an Accelerated Mouse Model of Diabetic Kidney Disease [0.03%]
microRNA-451通过调节自噬相关信号通路影响糖尿病肾病小鼠模型肾纤维化进展的作用及机制研究
Chidera Obiwuma,Baiyee-Ndang Agbor-Baiyee,Sadaf Ghaderzadeh et al.
Chidera Obiwuma et al.
Background: Diabetic nephropathy is characterized by metabolic dysregulation, renal fibrosis, and impaired autophagy. MicroRNA-451 (miR-451) has been implicated in metabolic and stress-response pathways, but its role in d...
Creatinine/Cystatin C Ratio as a Surrogate Marker for Sarcopenia in Hepatitis-C-Associated Liver Cirrhosis After Achieving a Sustained Virologic Response [0.03%]
HCV相关肝硬化患者持续病毒学应答后肌萎缩的替代标志物血清肌酐/半胱氨酸C比值的研究
Aritoshi Koizumi,Tadashi Namisaki,Akihiko Shibamoto et al.
Aritoshi Koizumi et al.
The creatinine/cystatin C ratio (CCR) has emerged as a simple surrogate marker for muscle mass. This study aimed to evaluate the clinical utility of CCR in identifying sarcopenia among patients with hepatitis-C-virus-related liver cirrhosis...
Dietary Cannabis Seed Supplementation Attenuates Inflammation and Pancreatic Injury in a Cerulein-Induced Acute Pancreatitis Mouse Model [0.03%]
膳食饲喂 cannabis 种子通过抑制炎症和急性胰腺炎小鼠的胰腺损伤来减轻病症
Dong-Uk Kim,Bitna Kweon,Dong-Keun Kim et al.
Dong-Uk Kim et al.
Cannabis seed (CS), also known as hemp seed, is a nutrient-dense plant-derived food material rich in polyunsaturated fatty acids and bioactive components with reported anti-inflammatory properties. However, potential nutritional effects of ...