MD Simulation of Vector-Receptor Pharmacologic Pairs for Tumor-Specific Drug Delivery: Transfer of Boron Atoms by RGD Peptide to αvβ3 Integrin Receptor [0.03%]
肿瘤特异性药物传递的载体-受体药理配对的分子动力学模拟：RGD肽向αvβ3整联蛋白受体转移硼原子
Ivan Baigunov,Kholmirzo Kholmurodov,Jaloliddin Gafurzoda et al.
Ivan Baigunov et al.
We utilized molecular dynamics (MD) simulations to explore the interaction of the RGD peptide with the αvβ3 integrin receptor, a key process for targeted drug delivery to tumors. The goal of these simulations was to model the transport of...
A Preliminary Investigation of the Anti- Salmonella Enteritidis Potential of Quercetin in Chickens Using Network Pharmacology, Molecular Docking, and In Vitro Antibacterial Assays [0.03%]
网络药理学、分子对接和体外抗菌试验结合初步研究槲皮素对鸡沙门氏菌的潜在作用
Qi Xiao,Yufeng Yan,Zihao Zhao et al.
Qi Xiao et al.
Salmonella Enteritidis is a major threat to poultry health and food safety, underscoring the need for safe alternatives to conventional antibiotics. In this study, quercetin, a natural flavonoid with antibacterial and immunomodulatory prope...
Natural Products in Endometrial Cancer: Molecular Mechanisms, Preclinical Evidence, and Clinical Perspectives [0.03%]
子宫内膜癌中的天然产物：分子机制，药效证据和临床展望
Hsien-Chang Wu,Chung-Che Tsai,Chan-Yen Kuo
Hsien-Chang Wu
Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries, with increasing incidence linked to obesity and metabolic dysfunction. While early-stage EC is often curable, advanced and recurrent disease remains d...
Exploring the Biological Potency of Carotenoids Against Alzheimer's Disease: An Integrated Approach of Molecular Docking and Molecular Dynamics [0.03%]
基于分子对接和分子动力学的类胡萝卜素抗阿尔茨海默病生物活性的综合研究
Meriem Khedraoui,El Mehdi Karim,Imane Yamari et al.
Meriem Khedraoui et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by cholinergic dysfunction, amyloid-β aggregation, mitochondrial stress, and aberrant kinase activity. Carotenoids, naturally occurring pigments with ant...
Precision Intervention of Isorhamnetin Total Flavonoids in Ischemic Heart Failure: Mechanistic Exploration Based on Signature Gene Targets [0.03%]
异鼠李素总黄酮精准干预缺血性心力衰竭的机制探索及靶基因筛选
Li-Juan Zhang,Xu Hu,Kader Kaderyea et al.
Li-Juan Zhang et al.
Early identification of ischemic heart failure (IHF) is critical for improving patient prognosis and clinical outcomes. However, effective diagnostic biomarkers and targeted therapeutic strategies for IHF remain limited. Total flavonoids fr...
Formulation of Blumea balsamifera, Anredera cordifolia, and Phyllanthus niruri Extracts as Potential Anti-Inflammatory Agents [0.03%]
白香花、心叶紫葳和菥蓂提取物抗炎活性研究
Siti Martinah Pajriah,Dyah Iswantini,Henny Purwaningsih et al.
Siti Martinah Pajriah et al.
Inflammation is an immune response to foreign substances, pathogens, and cellular damage, characterized by redness, pain, and swelling. The use of synthetic anti-inflammatory drugs may cause adverse side effects, prompting the need for natu...
Identification of Potential Pancreatic Lipase Inhibitors from Traditional Chinese Medicines via Molecular Docking, Molecular Dynamics Simulation and In Vitro Validation [0.03%]
基于分子对接、分子动力学模拟及体外验证的中药泛酰肽酶抑制剂筛选研究
Zixuan Zhang,Jinhua Long,Tingting Li et al.
Zixuan Zhang et al.
Obesity represents one of the most critical global public health challenges. Pancreatic lipase (PL) serves as a key therapeutic target for obesity control, whereas clinical synthetic PL inhibitors are greatly restricted by adverse reactions...
TRIM24 Regulates Adaptation to Glucose Deprivation in Association with Aspartate Accumulation and Impaired AMPK Signaling [0.03%]
TRIM24通过与天冬氨酸累积和AMPK信号受损相关联调节适应葡萄糖剥夺
Xiaochen Yu,Duopeng An,Dadui Ren et al.
Xiaochen Yu et al.
Glucose deprivation is a major metabolic stress that requires coordinated adaptive responses to maintain cellular homeostasis and survival, yet the role of tripartite motif-containing 24 (TRIM24) in this process remains unclear. To address ...
Genome-Wide Identification and Expression Profiling of HD-Zip Family Genes in Flax (Linum usitatissimum L.) [0.03%]
黄麻HD-Zip家族基因的鉴定及表达分析
Yamin Niu,Yanni Qi,Limin Wang et al.
Yamin Niu et al.
The homeodomain-leucine zipper (HD-Zip) transcription factor family is conserved in land plants and is critical for regulating growth, development, and stress responses. Flax (Linum usitatissimum L.) is an economically valuable dual-purpose...
A Comparative Bioinformatics Analysis of the Transcriptomic Profiles of Peri-Implantitis and Periodontitis and Their Common Signaling Pathways with Atherosclerosis [0.03%]
种植体周围炎和牙周炎转录组特征的生物信息学分析及其与动脉粥样硬化的共有信号通路研究
Aleksandr V Guskov,Anatoliy S Utyuzh,Aleksandr A Oleynikov et al.
Aleksandr V Guskov et al.
(1) Objective. To conduct a comparative bioinformatics analysis of the transcriptomic profiles of peri-implantitis and periodontitis to identify common and specific molecular signatures underlying their pathogenesis, as well as molecular pa...