Genome-Wide Association Study Suggests rrp44 Is a Key Regulator of Growth Traits in Channel Catfish (Ictalurus punctatus) [0.03%]
全基因组关联分析发现rrp44是斑点叉尾鮰生长性状的关键调控基因
Shiyong Zhang,Hongyan Liu,Yongqiang Duan et al.
Shiyong Zhang et al.
Understanding the genetic architecture underlying growth variation is central to improving aquaculture species through genomic selection. Here, we performed a genome-wide association study (GWAS) on 303 individuals from a G2 breeding popula...
Challenges and Limitations in Molecular Testing of Resected Non-Small Cell Lung Cancer Specimens [0.03%]
可切除非小细胞肺癌标本分子检测的挑战与局限性
Nikolaos Korodimos,Ioannis Tomos,Periklis Foukas et al.
Nikolaos Korodimos et al.
Non-small cell lung cancer (NSCLC) accounts for nearly 85% of lung cancer cases and remains a leading cause of cancer-related mortality worldwide. Advances in molecular diagnostics and targeted therapies have transformed treatment paradigms...
Brain-Derived Cystathionine β-Synthase-Generated H2S Attenuates Cerebral Ischemia-Reperfusion Injury via VEGFR2-Mediated Angiogenesis in MCAO/R Rats [0.03%]
脑源性半胱氨酸β-合成酶生成的H2S通过VEGFR2介导的新生血管形成缓解中风后的脑损伤
Shuai Liang,La Jiang,Yu Jiang et al.
Shuai Liang et al.
Ischemic stroke (IS) remains a major cause of global disability and mortality. While exogenous H2S has demonstrated neuroprotective potential, the role of endogenous H2S generated by cystathionine β-synthase (CBS) in cerebral ischemia-repe...
Psychedelics and Autism Therapy: A Review of Current Research and Future Directions [0.03%]
psychedelics和自闭症治疗：当前研究与未来方向综述
Christopher S Gondi,Manu Gnanamony,Tarun P Gondi et al.
Christopher S Gondi et al.
Autism Spectrum Disorder (ASD) is a lifelong condition marked by challenges in social communication and repetitive behaviors. Current treatments, primarily behavioral therapies, often fail to address the core symptoms. Recent research has e...
Identification of Key Genes Regulated by Lactylation Modification and Associated with Tumor Immune Microenvironment in Breast Cancer [0.03%]
乳腺癌中乳酰化修饰调控的关键基因与肿瘤免疫微环境的相关性分析
Yaohong Xie,Yi Ge,Na Miao et al.
Yaohong Xie et al.
Breast cancer (BRCA) is the most common cancer worldwide, with an incidence exceeding that of lung cancer. Protein lactylation, a newly identified post-translational modification involving the binding of lactic acid to lysine residues, play...
Rapid and Efficient Creation of Sweet-Waxy Maize Germplasm via CRISPR/Cas9-Mediated Gene Editing of Sh2 and Wx [0.03%]
利用CRISPR/Cas9同时编辑Sh2和Wx基因高效创制甜糯玉米新种质
Xiaolan Yan,Junnan Li,Huijian Liu et al.
Xiaolan Yan et al.
Sweet-waxy maize is a highly valuable specialty maize type with an increasing market demand, but conventional breeding methods for producing sweet-waxy maize are restricted by severe bottlenecks, such as long breeding cycles and linkage dra...
Long Non-Coding RNAs in Human Disease: An Overview of Biogenesis, Molecular Mechanism and Therapeutic Opportunities [0.03%]
人类疾病中的长非编码RNA：生物生成、分子机制及治疗机会综述
Arvind Kumar Dubey,Anil Kumar,Zhadyrassyn Nurbekova et al.
Arvind Kumar Dubey et al.
LncRNAs, defined as transcripts longer than 200 nucleotides with limited protein-coding potential, have emerged as important regulators of gene expression across multiple levels of cellular regulation. These molecules influence chromatin or...
Curcumin Attenuates LPS-Induced Migration/EMT and LPS/ATP-Associated IL-1β Release in Androgen-Independent Prostate Cancer Cells [0.03%]
姜黄素通过下调LPS/ATP诱导的NLRP3炎症小体信号通路抑制前列腺癌细胞的迁移及上皮间质转化
Mon-Der Cho,Shang-Yu Chou,Yu-Ming Hsu et al.
Mon-Der Cho et al.
Inflammation can promote aggressive phenotypes in prostate cancer, including enhanced migration/EMT-like changes and inflammasome-associated cytokine release. Here, we examined whether curcumin modulates these inflammation-driven responses ...
Angelic Acid Prevents RANKL-Induced Osteoclastogenesis Through Pathway-Biased Inhibition of MAPK-NFATc1 Signaling [0.03%]
天冬酰胺内酸通过偏向抑制MAPK-NFATc1信号通路来阻止RANKL诱导的破骨细胞生成
Lifang Zhang,Mojtaba Tabandeh,Vishwa Deepak
Lifang Zhang
Excessive osteoclast activity drives inflammatory bone loss in osteoporosis, rheumatoid arthritis, and periodontitis. Natural compounds represent promising therapeutic candidates with favorable safety profiles; however, few exhibit pathway-...
Integrative Multi-Omics Analysis Reveals the Immunoregulatory Effects of Sepia Ink on ADHD-like Phenotypes [0.03%]
整合多组学分析揭示墨鱼墨对注意缺陷多动障碍表型免疫调节作用机制
Baohong Wei,Jiayi Yin,Wenmin Yuan et al.
Baohong Wei et al.
Attention-Deficit/Hyperactivity Disorder (ADHD), affecting 5-10% of children globally, faces treatment limitations due to adverse effects and uncertain long-term risks of current pharmacotherapies. This study investigated the therapeutic po...