Multi-Target Restoration of Dermal Elastic Fibers Through Elastin Upregulation, Elastase Suppression, and Scaffold Reinforcement [0.03%]
通过弹性蛋白上调、降解抑制和支架增强实现真皮弹性纤维的多靶点修复
Sanghyun Ye,Seongsu Kang,Eui Taek Jeong et al.
Sanghyun Ye et al.
Elastic fibers are key components of the skin extracellular matrix and are essential for maintaining skin integrity and elasticity. During skin aging, particularly photoaging, elastic fiber integrity is progressively compromised by increase...
Redox-Regulated Mitophagy and Lysosomal Dysfunction as a Convergent Mechanism in Female Infertility: Molecular Insights and Therapeutic Perspectives [0.03%]
红氧化调控的线粒体自噬和溶酶体功能障碍在女性不孕中的汇聚机制：分子见解与治疗前景
Charalampos Voros,Fotios Chatzinikolaou,Georgios Papadimas et al.
Charalampos Voros et al.
Conventional hormonal and clinical models inadequately clarify the complex and diverse aspects of female infertility, resulting in poor reproductive outcomes and reduced egg viability. A growing body of research indicates that female reprod...
The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells [0.03%]
拓扑替康对人细胞作用的影响以及TDP1抑制剂OL9-116的衍生松果酸的作用
Tatyana E Kornienko,Arina A Chepanova,Maria V Kolobenko et al.
Tatyana E Kornienko et al.
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. We have previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the antican...
Association of Serum ELMO-3 Levels with Metastatic Status and Survival Outcomes in Non-Small Cell Lung Cancer [0.03%]
肺癌EMLO-3蛋白表达水平及其临床意义
Hilal Oğuz Soydinç,Murat Serilmez,Ceren Tilgen Yasasever et al.
Hilal Oğuz Soydinç et al.
Non-small cell lung cancer remains one of the leading causes of cancer-related mortality worldwide, and identifying molecular markers associated with tumor progression and metastasis is important for improving patient management. This study...
Microglial Innate Immune Memory: Implications and Research Advances in Central Nervous System Disorders [0.03%]
小胶质细胞固有免疫记忆在中枢神经系统疾病中的意义和研究进展
Yaru Song,Shiyi Shu,Xiansi Zeng et al.
Yaru Song et al.
The central nervous system (CNS), comprising the brain and spinal cord, represents the core regulatory hub of the body. Damage to the CNS often leads to irreversible structural and functional impairments of neural tissues, posing a major gl...
Epigenetic and Transcriptomic Pathways Underlying Animal Models of Cognitive and Psychiatric Disorders: A Scoping Review [0.03%]
认知和精神障碍动物模型的表观遗传和转录组学路径综述性研究
Jaishriram Rathored,Ajay Pal,Deepika Sai Painkra
Jaishriram Rathored
Background: Cognitive and psychiatric disorders are caused by a complex interplay between genetic predisposition, environmental exposures, and dynamic molecular regulation in the brain. Animal models provide a controlled environment for exa...
Coptis chinensis Franch. Suppresses Invasive Pulmonary Aspergillosis by Augmenting NADPH-Dependent Neutrophil Extracellular Traps via Dual Modulation of Complement Activation and Gut Microbiota [0.03%]
黄连通过双重调节补体激活和肠道微生物群增强NADPH依赖的中性粒细胞胞外陷阱来抑制侵袭性肺曲霉病
Zhuqiao Jiang,Lingmei Zhou,Jinping Wang et al.
Zhuqiao Jiang et al.
Invasive pulmonary aspergillosis (IPA) poses a serious threat to immunocompromised hosts, with limited therapeutic options highlighting the need for novel strategies. Coptis chinensis Franch. (CCF), a traditional Chinese herb containing ant...
Mining and Analysis of Salt Tolerance Genes in Maize at the Seedling Stage [0.03%]
maize苗期耐盐基因的挖掘与分析
Zhenping Ren,Zelong Zhuang,Jianwen Bian et al.
Zhenping Ren et al.
Salt stress represents a significant abiotic stress factor that adversely affects plant growth and development. It directly inhibits both vegetative and reproductive growth, resulting in substantial reductions in crop yield and quality. Con...
Molecular Genetics of Bartter Syndrome: Bridging Genotype-Phenotype Correlations and Precision Therapeutics [0.03%]
巴特综合征的分子遗传学：连接基因型-表型相关性和精准治疗
Lina Zhu,Yang Li,Yiyao Bao
Lina Zhu
Bartter syndrome (BS) represents a group of rare, autosomal recessive renal tubular disorders characterized by hypokalemic hypochloremic metabolic alkalosis, secondary hyperaldosteronism, and normal to low blood pressure. The underlying pat...
Management of Pregnancy in Women with Inflammatory Bowel Disease: Positioning Janus Kinase Inhibitors Within Current Evidence [0.03%]
炎症性肠病妇女妊娠管理：现有证据下的Janus激酶抑制剂定位
Dario Colacurci,Raffaele Pellegrino,Alessia Lamart et al.
Dario Colacurci et al.
Inflammatory bowel diseases (IBD) frequently affect women of reproductive age. Disease activity may arise during pregnancy, at times in severe forms, thereby generating complex clinical scenarios. Adequate control of disease activity throug...