Photodynamic Therapy Targeting Matrix Metalloproteases in Cancer: Standpoint for an Innovative Anticancer Strategy [0.03%]
针对癌症金属基质蛋白酶的光动力治疗：创新抗癌策略的观点立场
Vanya Mantareva,Diana Braikova,Mingna Sun et al.
Vanya Mantareva et al.
Matrix metalloproteases (MMPs), which are activated during malignancy growth and metastasis, have been a focus of current anticancer research and development. The selective recognition and precise inhibition of active MMPs could limit cance...
Oridonin Suppresses Colorectal Cancer Growth In Vitro and In Vivo: Evidence from Integrated Transcriptomic and Proteomic Profiling [0.03%]
oridonin通过整合转录组和蛋白质组分析抑制结直肠癌的生长作用及机制研究
Menglong Xu,Yongchao Li,Wenqiang Sun et al.
Menglong Xu et al.
Colorectal cancer (CRC) remains a major cause of cancer-related mortality worldwide, and effective therapeutic options for advanced disease are still limited. Oridonin (ORI), a naturally derived diterpenoid compound, has shown anti-tumor ac...
A Customizable Tyramide Signal Amplification-Based Multiplex Immunofluorescence Protocol for FFPE Tissues [0.03%]
一种用于福尔马林固定石蜡包埋组织的基于邻苯二酚胺信号放大的多重免疫荧光检测方法
Wenjie Sheng,T M Mohiuddin,Chaoyu Zhang et al.
Wenjie Sheng et al.
Formalin-fixed paraffin-embedded (FFPE) tissues represent an invaluable resource for both basic and clinical research due to their stable preservation of tissue architecture and molecular integrity. Multiplex immunofluorescence (mIF) using ...
A Review of the Effect of Peripheral Amyloid β on the Central Nervous System [0.03%]
外周淀粉样β蛋白影响中枢神经系统的机制综述
Zulaikha Elia Zamzuri,Mohd Amir Kamaruzzaman,Seong Lin Teoh et al.
Zulaikha Elia Zamzuri et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder classically defined by cerebral amyloid β (Aβ) plaque deposition and tau pathology. In recent years, AD has increasingly been recognized as a multisystem disorder rather...
Total Antioxidant Capacity and Total Oxidative Capacity in Multi-Modal Opioid-Based Therapy for Non-Cancer Pain: Analysis of Redox Status [0.03%]
多模式阿片类药物治疗非癌症疼痛的总抗氧化能力和总氧化能力：红氧平衡状态分析
Urszula Kosciuczuk,Piotr Jakubow,Marcin Talalaj et al.
Urszula Kosciuczuk et al.
Current scientific reports on pain pharmacotherapy focus on the side effects of opioid medications related to dysregulation of the oxidative-antioxidant balance and immunomodulation. Initial observations concerned the use of opioids in the ...
Transcriptional Divergence of Conserved Starch Metabolism Genes During Grain Filling in Indica and Japonica Rice [0.03%]
籼稻和粳稻灌浆期保守淀粉代谢基因的转录分化分析
Me-Sun Kim,Jin-Young Kim,Donghwan Shim et al.
Me-Sun Kim et al.
Rice grain quality is strongly influenced by starch composition and structure, which differ between the two major cultivated Oryza sativa subspecies, indica and japonica. Although allelic variation in several key genes has been linked to th...
Role of Sirtuin 6 in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease [0.03%]
Sirtuin 6在代谢功能障碍相关性脂肪肝病发病机制中的作用
Yeonsoo Kim,Seonghwan Hwang
Yeonsoo Kim
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide and arises from systemic metabolic dysregulation and insulin resistance. Despite its increasing prevalence, effective pha...
Regulation and Implementation of Apoptosis in Melanoma Tumor Cells with BRAF, NRAS, and NF1 Gene Mutations [0.03%]
BRAF、NRAS和NF1基因突变的黑色素瘤肿瘤细胞凋亡的调控与实现
Olga L Nosareva,Ekaterina A Pomytkina,Olga N Korotkova et al.
Olga L Nosareva et al.
This review explores the molecular mechanisms regulating signaling pathways that may be potentially involved in modulating apoptosis in melanoma tumor cells harboring mutations in BRAF, NRAS, and NF1 genes. The high mortality associated wit...
Diagnostic Value of Circulating Long Non-Coding RNAs HOTAIR, NEAT1, and CCAT1 for Colorectal Cancer: A Vietnamese Case-Control Study [0.03%]
循环长链非编码RNA HOTAIR、NEAT1和CCAT1对结直肠癌诊断价值的越南病例对照研究
Khanh Ngoc Nguyen,Diem Thi Nguyen,Khanh Hong Pham et al.
Khanh Ngoc Nguyen et al.
Circulating long non-coding RNAs (lncRNAs) have emerged as promising non-invasive biomarkers for colorectal cancer (CRC) detection; however, data in Vietnamese populations remain limited. In this study, a total of 218 participants (106 CRC,...
ROS Generation and Redox Enzyme Activity in the Stigmas of Two Tobacco Plant Lines with Different Seed Productivity Levels [0.03%]
两种不同种子生产力烟草品系花药中ROS的产生及红氧酶活性
Ekaterina N Baranova,Tatiana Kalashnikova,Oksana Luneva et al.
Ekaterina N Baranova et al.
Nicotiana tabacum is a classic model for studying pollination on wet stigma. Reactive oxygen species (ROS) and nitric oxide (NO) production are closely related to stigma fertility and depend on the activity of redox enzymes. This study is d...