Network Pharmacology and In Vitro Experimental Validation Reveal the Anti-Inflammatory and Anti-Apoptotic Effects of Lotus Leaf Extract in Treating Inflammatory Diarrhea in Pigs [0.03%]
网络药理学和体外实验验证莲花叶提取物治疗猪炎症性腹泻的抗炎和抗凋亡作用
Yu Zheng,Jiana Zheng,Jiao Wang et al.
Yu Zheng et al.
The objective of this research was to investigate the efficacy of lotus leaf in the prevention and treatment of inflammatory diarrhea in pigs, utilizing network pharmacology and in vitro methodologies. Initially, LC-MS was employed to analy...
A Transcriptomic Study on the Toxic Effects of Iodide (I-) Wet Deposition on Pepper (Capsicum annuum) Leaves [0.03%]
碘湿沉降对辣椒叶片毒害的转录组学研究
Rui Yu,Zhu-Ling Ma,Min Wang et al.
Rui Yu et al.
Radioactive iodine (129I), released into the environment from human nuclear activities, poses significant health risks to the biosphere due to its long half-life and mobility. This study investigates the toxic effects of wet-deposited iodin...
A Novel Application of RNA In Situ Hybridization in the Analysis of Vitamin D Receptor Expression in Psoriatic Skin Tissue Following Etanercept Treatment [0.03%]
依那西普治疗银屑病后外周血和皮损组织中维生素D受体的差异表达及意义研究新方法：RNA原位杂交法
Max Lundgren,Alexandra Kuliszkiewicz,Martin Gillstedt et al.
Max Lundgren et al.
Psoriasis is a chronic inflammatory skin disease marked by abnormal keratinocyte proliferation and immune dysregulation. The vitamin D receptor (VDR) plays a crucial role in regulating skin cell growth and immune responses, but its expressi...
Poria cocos Ethanol Extract Restores MK-801-Induced Cytoskeleton Regulation in Neuro2A and IMR-32 Cells and Locomotor Hyperactivity in C57BL/6 Mice by Modulating the Rho Signaling Pathway [0.03%]
自发性肾小球疾病大鼠血管内皮细胞活化的分子机制研究
Ya-Ying Chang,Cheng-Wei Lu,Tzu-Yu Lin et al.
Ya-Ying Chang et al.
Poria cocos extract attenuates MK-801-induced hyperactivity via RhoA/ROCK1 pathway modulation in mice. Background/objectives: Poria cocos (P. cocos), a tr...
Harnessing Exosomes: A Brief Overview of Nature's Nanocarriers and a Glimpse into Their Implications in Pituitary Neuroendocrine Tumors (PitNETs) [0.03%]
利用外泌体：大自然纳米载体的简要概述及其在垂体神经内分泌肿瘤（PitNET）中的意义初探
Ligia Gabriela Tataranu
Ligia Gabriela Tataranu
The study of exosomes is currently an area of major interest in the scientific world, especially after the discovery of their function as natural nanocarriers. Their intrinsic features in regulating intricate intracellular pathways have put...
Targeting SHP2 with Natural Products: Exploring Saponin-Based Allosteric Inhibitors and Their Therapeutic Potential [0.03%]
天然产物靶向SHP2：基于皂苷的别构抑制剂及其治疗潜力的研究
Dong-Oh Moon
Dong-Oh Moon
SHP2, a non-receptor protein tyrosine phosphatase, plays a pivotal role in regulating intracellular signaling pathways, particularly the RAS/MAPK and PI3K/AKT cascades, which are critical for cellular proliferation, differentiation, and sur...
Fraxin Alleviates Atherosclerosis by Inhibiting Oxidative Stress and Inflammatory Responses via the TLR4/PI3K/Akt Pathway [0.03%]
/fraxin通过tlr4/pi3k/a kt途径抑制氧化应激和炎症反应缓解动脉粥样硬化
Yaru Wang,Bailing Wei,Mingyang Leng et al.
Yaru Wang et al.
Fraxin is a bioactive compound derived from Cortex Fraxini. It is known for its diverse biological activities and numerous benefits, including anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, and immunomodulatory effects...
Alicja Jasieniecka,Inês Domingues
Alicja Jasieniecka
CRISPR-Cas9 has revolutionized genetic research with bioinformatics tools essential for tasks like guide RNA design, off-target prediction, and data analysis. This systematic review summarizes the functionality and key features of such tool...
A Pilot Investigation of Circulating miRNA Expression in Individuals Exposed to Aluminum and Welding Fumes [0.03%]
铝和焊接烟雾暴露个体循环miRNA表达的初步研究
Gözde Öztan,Halim İşsever,Tuğçe İşsever et al.
Gözde Öztan et al.
The objectives of this study comprise the identification of key miRNAs and their target genes associated with severe tolerance in individuals exposed to aluminum and welding fumes, and the elucidation of the underlying regulatory mechanisms...
Genetic Diversity and Breeding System of the Pestiferous Subterranean Termite Reticulitermes flaviceps Across Shaanxi and Sichuan Provinces [0.03%]
基于陕西和四川两省的散堆滑膛鼻白蚁种群遗传多样性及交配制度研究
Zahid Khan,Haroon,Yu-Feng Meng et al.
Zahid Khan et al.
The genetic diversity of 22 colonies of the termite Reticulitermes flaviceps was analyzed in Shaanxi and Sichuan provinces. It was found that the genetic diversity in both regions was quite similar. However, the distribution of genetic vari...