Molecular Subtypes and Biomarkers of Ulcerative Colitis Revealed by Sphingolipid Metabolism-Related Genes: Insights from Machine Learning and Molecular Dynamics [0.03%]
机器学习和分子动力学揭示的溃疡性结肠炎分子亚型及鞘脂代谢相关基因生物标志物研究
Quanwei Li,Junchen Li,Shuyuan Liu et al.
Quanwei Li et al.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with disrupted lipid metabolism. This study aimed to uncover novel molecular subtypes and biomarkers by integrating sphingolipid metabolism-related genes (SMGs) with...
Elucidating the Role of CNOT2 in Regulating Cancer Cell Growth via the Modulation of p53 and c-Myc Expression [0.03%]
揭示CNOT2通过调节p53和c-Myc表达调控癌细胞增殖的作用机制
Jihyun Lee,Ju-Ha Kim,Yu Jin Lee et al.
Jihyun Lee et al.
CNOT2, a central component of the CCR4-NOT transcription complex subunit 2, plays a pivotal role in the regulation of gene expression and metabolism. CNOT2 is involved in various cellular processes, including transcriptional regulation, mRN...
Oxidative-Inflammatory Crosstalk and Multi-Target Natural Agents: Decoding Diabetic Vascular Complications [0.03%]
氧化炎症相互作用及多靶向天然药物剂：解读糖尿病血管并发症
Jingwen Liu,Kexin Li,Zixin Yi et al.
Jingwen Liu et al.
Diabetes mellitus (DM) is one of the leading causes of death and disability worldwide and its prevalence continues to rise. Chronic hyperglycemia exposes patients to severe complications. Among these, diabetic vascular lesions are the most ...
Feng Zhou,Jia-Bin Zhou,Tian-Peng Wei et al.
Feng Zhou et al.
Diabetes mellitus poses a significant global health challenge, primarily due to its chronic metabolic dysregulation, leading to widespread tissue and organ damage. This systemic impact results in a range of complications that markedly reduc...
Prothrombotic Genetic Mutations Are Associated with Sub-Clinical Placental Vascular Lesions: A Histopathological and Morphometric Study [0.03%]
凝血基因突变与亚临床胎盘血管病灶的相关性：组织病理学和形态计量学研究
Viorela-Romina Murvai,Anca Huniadi,Radu Galiș et al.
Viorela-Romina Murvai et al.
Background: Inherited thrombophilia is increasingly recognized as a contributing factor to placental vascular pathology and adverse pregnancy outcomes. While the clinical implications are well-established, fewer studies h...
Xylitol Antioxidant Properties: A Potential Effect for Inflammation Reduction in Menopausal Women?-A Pilot Study [0.03%]
木糖醇抗氧化特性：对绝经期女性消炎的潜在影响？-一项试点研究
Ilona Górna,Magdalena Kowalówka,Barbara Więckowska et al.
Ilona Górna et al.
Introduction: Oxidative stress is a key factor in the pathogenesis of many chronic diseases, especially in postmenopausal women. Xylitol, a sugar alcohol with potential antioxidant properties, may affect oxidative balance...
Combined Bioinformatic and Experimental Approaches to Analyze miR-182-3p and miR-24-3p Expression and Their Target Genes in Gestational Diabetes Mellitus and Iron Deficiency Anemia During Pregnancy [0.03%]
联合生物信息学和实验方法分析妊娠期糖尿病和缺铁性贫血期间miR-182-3p和miR-24-3p的表达及其靶基因
Badr Alzahrani,Bisma Rauff,Aqsa Ikram et al.
Badr Alzahrani et al.
Gestational diabetes mellitus (GDM) and iron deficiency anemia (IDA) are the most common pregnancy-related conditions resulting in adverse maternal and fetal complications. MicroRNAs (miRNAs), particularly miR-182-3p and miR-24-3p, are prom...
Molecular Targets for Pharmacotherapy of Head and Neck Squamous Cell Carcinomas [0.03%]
头颈部鳞状细胞癌药物治疗的分子靶点
Robert Sarna,Robert Kubina,Marlena Paździor-Heiske et al.
Robert Sarna et al.
Head and neck squamous cell carcinomas (HNSCCs) represent a heterogeneous group of tumors with a complex molecular profile. Despite therapeutic advances, patient prognosis remains poor, emphasizing the need for more effective treatment stra...
Bromelain Improves Hypothalamic Control of Energy Homeostasis in High-Fat Diet-Induced Obese Rats [0.03%]
菠萝蛋白酶通过改善高脂饮食诱导的肥胖大鼠下丘脑对能量平衡的调控来减轻体重
Raviye Ozen Koca,Mustafa Berk Basaran,Hatice Solak et al.
Raviye Ozen Koca et al.
Obesity remains a major global health challenge with limited therapeutic options. Bromelain, a proteolytic enzyme complex derived from pineapple, has been recognized for its natural anti-inflammatory, anti-edematous, and appetite-suppressin...
Inhibitory Effects of 3-Deoxysappanchalcone on Particulate-Matter-Induced Pulmonary Injury [0.03%]
3-脱氧萨普烷香豆素对颗粒物致肺损伤的抑制作用
Chang-Woo Ryu,Jinhee Lee,Gyuri Han et al.
Chang-Woo Ryu et al.
Fine particulate matter (PM2.5) exposure has been linked to increased lung damage due to compromised vascular barrier function, while 3-deoxysappanchalcone (3-DSC), a chalcone derived from Caesalpinia sappan, is known for its pharmacologica...