Charlotte Delrue,Reinhart Speeckaert,Marijn M Speeckaert
Charlotte Delrue
Genome-wide association studies (GWAS) have transformed the study of chronic kidney disease (CKD) by identifying hundreds of genetic loci associated with multiple aspects of kidney function, including albuminuria and CKD risk factors, in di...
Potential Factors of Diabetes in Gitelman Syndrome and the Choices of the Appropriate Hypoglycemic Drugs: A Literature Narrative Review [0.03%]
Gitelman综合征糖尿病的潜在因素及其降糖药物选择的相关文献综述
Izabela Szubert,Aleksandra Cader-Ptak,Ewa Kwiatkowska
Izabela Szubert
Gitelman syndrome (GS) is a rare, autosomal recessive salt-losing tubulopathy caused by mutations in the SLC12A3 gene. It involves dysfunction of the sodium-chloride cotransporter positioned on the apical membranes of the distal convoluted ...
Loss of Function of the Zxdb Gene Leads to a Decrease in the Decidualization Rate and Number of Pups Born in Mice by Affecting the Expression of the Cell Adhesion Molecules [0.03%]
Zxdb基因功能丧失通过影响细胞黏附分子的表达降低小鼠蜕膜化率和产仔数
Yafei Tian,Yang Zhang,Mengru Li et al.
Yafei Tian et al.
The Zinc Finger X-Linked Duplicate B (ZXDB) gene is one of a pair of replicated zinc finger genes on chromosome Xp11.21. The homologous gene of ZXDB in mice is Zxdb. Recent studies have found that Zxdb plays a role in the spermatogenic proc...
Neuroprotective Potential of New Monoterpene-Adamatane Conjugates-A Pilot Study [0.03%]
新单萜亚胺类化合物的神经保护潜力——一项初步研究
Stela Dragomanova,Polina Petkova-Kirova,Konstantin Volcho et al.
Stela Dragomanova et al.
Neurodegenerative diseases, including Alzheimer's disease, are marked by cholinergic dysfunction, oxidative stress, and reduced neurotrophic support, which drives the quest for multifunctional therapeutic agents. This pilot study presents f...
Construction of a Prognostic Model for Lung Adenocarcinoma Based on Necrosis by Sodium Overload-Related Genes and Identification of DENND1C as a New Prognostic Marker [0.03%]
基于钠超载相关基因构建肺腺癌坏死预后模型并鉴定DENND1C为新的预后标志物
Huijun Tan,Yang Zhang,Maoting Tan et al.
Huijun Tan et al.
Background: Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality. The prognostic significance and functional role of sodium overload-induced necrosis (a novel form of regulated cell death driven by disrupted sodium...
Are Peripartum Changes in CCL2 Associated with Maternal Metabolic Status? [0.03%]
围产期CCL2的变化与母体代谢状态有关吗？
Aleksandra Obuchowska-Standyło,Żaneta Kimber-Trojnar,Katarzyna Trojnar et al.
Aleksandra Obuchowska-Standyło et al.
C-C motif chemokine ligand 2 (CCL2) may reflect subtle metabolic-inflammatory changes in pregnancy. This study evaluated CCL2 concentrations and their peripartum changes in women with uncomplicated term pregnancies, focusing on associations...
Design and In Vitro Evaluation of Novel GC373-like SARS-CoV-2 Main Protease Inhibitors [0.03%]
新型GC373类SARS-CoV-2主要蛋白酶抑制剂的设计与体外评价
Aleksandra A Kuznetsova,Aleksandr P Makhin,Anatoliy A Bulygin et al.
Aleksandra A Kuznetsova et al.
Significant advances in coronavirus immunoprophylaxis have enabled the control of the SARS-CoV-2 pandemic. However, the continued emergence of SARS-CoV-2 variants with immune escape potential highlights the need for effective direct-acting ...
Rapid Identification of Candidate SNPs and QTLs for Capsicum annuum Chili Fruit Size and Capsaicin Content Using ddRAD-Sequencing and Bulk Segregant Analysis [0.03%]
利用ddRAD测序和简化群体分析鉴定辣椒果实大小及辣椒素含量的候选SNP位点和QTL区间
Misbah Naseem,Adrian Christopher Brennan,Rashid Mehmood Rana et al.
Misbah Naseem et al.
Fruit size and pungency are key yield and quality traits in chili. This study combines high-throughput genotyping with bulk segregant analysis (BSA) to identify candidate SNPs and quantitative trait loci (QTLs) by analyzing extreme phenotyp...
Interleukin Signatures as Prognostic Biomarkers in Ulcerative Colitis: From Immune Pathways to Clinical Prediction [0.03%]
溃疡性结肠炎中白细胞介素特征作为预后生物标志物的价值：从免疫通路至临床预测
Nikolaos Martinos,Andreas C Lazaris,Christos Kroupis et al.
Nikolaos Martinos et al.
Ulcerative colitis (UC) is a chronic immune-mediated inflammatory disease characterized by substantial heterogeneity in histologic activity, which is frequently uncoupled from clinical symptoms and endoscopic findings. Persistent microscopi...
Cross-Species Upregulation of MAGED2 in Liver Cancer Suggests a Role in Obesity-Driven Tumor Progression [0.03%]
MAGED2在肝癌中的跨物种上调表明其可能参与肥胖驱动的肿瘤进展
Tara Bayat,Farzana Yeasmin Popy,Rebecca R Florke Gee et al.
Tara Bayat et al.
Melanoma-associated antigens (MAGEs) are cancer-testis antigens (CTAs) aberrantly expressed in multiple cancer types, including hepatocellular carcinoma (HCC), and associated with aggressive phenotypes. Although MAGE proteins are widely stu...