The Antihistamine Astemizole Potentiates the Antitumor Efficacy of Sorafenib in Hepatocellular Carcinoma by Suppressing Proliferation, Metastasis, and Angiogenesis [0.03%]
抗组胺药阿司咪唑通过抑制增殖、转移和血管生成增强索拉非尼在肝细胞癌中的抗肿瘤功效
Yixuan Zhang,Xin Chen,Xuting Yang et al.
Yixuan Zhang et al.
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with a poor prognosis. While sorafenib serves as the first-line therapy for advanced HCC, its efficacy is frequently hampered by side effects and the development of drug resis...
Proton Irradiation Induces Differential Cellular Responses and Proteomic Signatures in Chondrosarcoma and Chondrocytes [0.03%]
质子照射诱导软骨肉瘤和软骨细胞差异性细胞反应及蛋白质标志物产生
Mihaela Tudor,Roxana Cristina Popescu,Benoît Bernay et al.
Mihaela Tudor et al.
Chondrosarcoma (CHS), the second most common primary malignant cartilage tumor, is largely resistant to conventional therapies, making surgical resection the standard treatment. Proton therapy offers a physical advantage through the Bragg p...
WWOX-Related Epileptic Encephalopathy (WOREE Syndrome): Clinical Case Study and Literature Review [0.03%]
WOX相关性癫痫性脑病(WOREE综合征):临床病例研究及文献综述
Annamaria Sapuppo,Roberta Rizzo,Gaia Fusto et al.
Annamaria Sapuppo et al.
The WW domain-containing oxidoreductase (WWOX) gene, well-known as a tumor suppressor, also has a crucial role as a transcription factor in the developing brain. The bi-allelic loss of the WWOX gene causes a condition characterized by drug-...
Pyrogallol Contributes to the Anti-Allergic and Anti-Inflammatory Activities of Rosebud Extracts of Newly Crossbred Roses [0.03%]
愈创木酚对新培育玫瑰花蕾提取物抗过敏和抗炎活性的贡献
In-Jeong Kim,Khan-Erdene Tsolmon,Zolzaya Bavuu et al.
In-Jeong Kim et al.
Since chemical anti-allergic compounds have adverse effects, many investigators pay attention to relatively safe natural products. Twenty-four newly crossbred rosebuds were extracted with 80% ethanol and analyzed for polyphenols, flavonoids...
TCOF1 Regulates Tumor Cell Migration Through p53-Dependent Mitochondrial Homeostasis and F-Actin Dynamics [0.03%]
TCOF1通过p53依赖的线粒体稳态和F肌动蛋白动力学调节肿瘤细胞迁移
Yuanyuan Jiang,Yao Wei,Daikang Yang et al.
Yuanyuan Jiang et al.
The deficiency of TCOF1 is closely associated with multiple cellular dysfunctions, but its function in mitochondrial homeostasis and cytoskeletal regulation remains unclear. First, our research revealed that TCOF1 deficiency significantly i...
The Bioactivity of Glycyrrhizae Radix et Rhizoma Praeparata cum Melle Carbon Dots: A Preliminary Study of Their Antiallergic Effect [0.03%]
甘草明蜜碳点的生物活性：抗过敏作用初步研究
Siqi Wang,Xiaohan Qu,Jinye Yuan et al.
Siqi Wang et al.
This study concurrently addressed the separation method for carbon dots derived from Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (GRRPM) and the in vitro evaluation of their anti-allergic biological activity. Glycyrrhizae Radix et Rh...
DPP-4 Inhibitors in Female Cancers: Opportunities for Drug Repurposing [0.03%]
DPP-4抑制剂在女性肿瘤治疗中的应用前景：老药新用的机遇
Hiba F Muddather,Zsuzsanna Schelz,István Zupkó
Hiba F Muddather
Female malignancies, including breast, cervical, ovarian, and endometrial cancers, remain a significant health challenge. Meanwhile, treatment options for advanced-stage remain limited. Drug repurposing has emerged as a promising approach t...
Selection and Validation of Stable Reference Genes for Accurate qRT-PCR Analysis of Flower Color Development in Rhododendron lapponicum [0.03%]
越橘花色发育的qRT-PCR分析中稳定参考基因的选择与验证
Liang Xu,Gang Lu,Fangwei Zhou et al.
Liang Xu et al.
Rhododendron lapponicum (L.) Wahlenb., prized for its vibrant and diverse floral displays, holds significant ornamental and ecological value. However, advances in its molecular breeding have been constrained by the absence of reliable tools...
Nivolumab Enhances the Cytotoxicity of Chemotherapeutic Agents in A549 Lung Adenocarcinoma Cell Lines [0.03%]
纳武单抗增强化疗药物对肺腺癌A549细胞系的细胞毒作用
Nilgün Okşak,Oğur Karhan
Nilgün Okşak
Background and objectives: The integration of chemotherapy (ChT) and immune checkpoint inhibitors (ICIs) has become a standard approach in oncology. Although the addition of ICIs to double-agent ChT regimens has demonstra...
Family-Based GWAS of Cognitive Endophenotypes Reveals Genetic Architecture of Memory and Executive Function in Alzheimer's Disease [0.03%]
基于家庭的认知内表型基因组-wide关联研究揭示了阿尔茨海默病患者记忆和执行功能的遗传结构
Kesheng Wang,Xueying Yang,Gayenell Magwood et al.
Kesheng Wang et al.
Alzheimer's disease (AD), the most common cause of dementia, is characterized by progressive memory and cognitive decline. Conventional genome-wide association studies (GWAS) comparing AD cases and controls may miss genetic influences that ...