Investigation of the adolescent female breast transcriptome and the impact of obesity [0.03%]
青春期女性乳房转录组和肥胖影响的研究
Adam Burkholder,Dennis Akrobetu,Arun R Pandiri et al.
Adam Burkholder et al.
Background: Early life environmental exposures affect breast development and breast cancer risk in adulthood. The breast is particularly vulnerable during puberty when mammary epithelial cells proliferate exponentially. I...
Comparative Study
Breast cancer research : BCR. 2020 May 11;22(1):44. DOI:10.1186/s13058-020-01279-6 2020
Quantitative stain-free imaging and digital profiling of collagen structure reveal diverse survival of triple negative breast cancer patients [0.03%]
定量无染色成像和数字化胶原结构分析揭示三阴性乳腺癌患者的生存差异
Laurent Gole,Joe Yeong,Jeffrey Chun Tatt Lim et al.
Laurent Gole et al.
Background: Stromal and collagen biology has a significant impact on tumorigenesis and metastasis. Collagen is a major structural extracellular matrix component in breast cancer, but its role in cancer progression is the ...
In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness [0.03%]
宫内雌激素干扰会改变细胞外基质密度和乳腺硬度
Clarissa Wormsbaecher,Andrea R Hindman,Alex Avendano et al.
Clarissa Wormsbaecher et al.
Background: In utero endocrine disruption is linked to increased risk of breast cancer later in life. Despite numerous studies establishing this linkage, the long-term molecular changes that predispose mammary cells to ca...
Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer [0.03%]
糖皮质激素受体是三阴性乳腺癌中TGFβ1诱导的p38 MAPK信号通路的作用效应器，对于肿瘤高级别表型的形成必不可少
Carlos Perez Kerkvliet,Amy R Dwyer,Caroline H Diep et al.
Carlos Perez Kerkvliet et al.
Background: Altered signaling pathways typify breast cancer and serve as direct inputs to steroid hormone receptor sensors. We previously reported that phospho-Ser134-GR (pS134-GR) species are elevated in triple-negative ...
Apolipoprotein-mediated regulation of lipid metabolism induces distinctive effects in different types of breast cancer cells [0.03%]
载脂蛋白介导的脂质代谢调节在不同类型的乳腺癌细胞中产生不同的效果
Céline Ben Hassen,Jorge L Gutierrez-Pajares,Cyrille Guimaraes et al.
Céline Ben Hassen et al.
Background: The highest incidence of breast cancer is in the Western world. Several aspects of the Western lifestyle are known risk factors for breast cancer. In particular, previous studies have shown that cholesterol le...
Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families [0.03%]
肿瘤测序有助于完善高风险乳腺癌家系的遗传变异分析
Cédric Van Marcke,Raphaël Helaers,Anne De Leener et al.
Cédric Van Marcke et al.
Background: Multigene panels are routinely used to assess for predisposing germline mutations in families at high breast cancer risk. The number of variants of unknown significance thereby identified increases with the nu...
Cetuximab PET delineated changes in cellular distribution of EGFR upon dasatinib treatment in triple negative breast cancer [0.03%]
西妥昔单抗正电子发射断层扫描显示达沙替尼治疗后三阴性乳腺癌EGFR细胞分布变化
Brooke N McKnight,Seongho Kim,Julie L Boerner et al.
Brooke N McKnight et al.
Background: At least 50% of triple negative breast cancer (TNBC) overexpress the epidermal growth factor receptor, EGFR, which paved the way for clinical trials investigating its blockade. Outcomes remained dismal stemmin...
Correction to: Serum exosomal-annexin A2 is associated with African-American triple-negative breast cancer and promotes angiogenesis [0.03%]
有关血清外泌体-Annexin A2与三阴性乳腺癌及促血管生成的纠正评论论文
Pankaj Chaudhary,Lee D Gibbs,Sayantan Maji et al.
Pankaj Chaudhary et al.
After publication of the original article [1], we were notified that the wrong version of Fig. 2b has been published.
Published Erratum
Breast cancer research : BCR. 2020 Mar 23;22(1):31. DOI:10.1186/s13058-020-01268-9 2020
Letter to the editor: Response to Giardiello D, Antoniou AC, Mariani L, Easton DF, Steyerberg EW [0.03%]
来信：回复Giardiello D, Antoniou AC, Mariani L, Easton DF, Steyerberg EW
Chang Ming,Valeria Viassolo,Nicole Probst-Hensch et al.
Chang Ming et al.
Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment [0.03%]
tgif1缺陷型骨微环境可减弱乳腺癌骨转移
Marie-Therese Haider,Hiroaki Saito,Jennifer Zarrer et al.
Marie-Therese Haider et al.
Background: Osteoclast activation is a hallmark of breast cancer-induced bone disease while little is known about the role of osteoblasts in this process. Recently, we identified the homeodomain protein TG-interacting fac...