PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim [0.03%]
通过调节Bim增强三阴性乳腺癌化疗敏感性的PRKCQ抑制作用
Jessica H Byerly,Elisa R Port,Hanna Y Irie
Jessica H Byerly
Background: Protein kinase C theta, (PRKCQ/PKCθ) is a serine/threonine kinase that is highly expressed in a subset of triple-negative breast cancers (TNBC) and promotes their growth, anoikis resistance, epithelial-mesenc...
Correction to: FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors [0.03%]
关于：FAK激活AKT-mTOR信号促进MMTV-Wnt1驱动的基底样乳腺肿瘤生长和发展的校正
Ritama Paul,Ming Luo,Xueying Mo et al.
Ritama Paul et al.
An amendment to this paper has been published and can be accessed via the original article.
Published Erratum
Breast cancer research : BCR. 2020 Jun 29;22(1):71. DOI:10.1186/s13058-020-01310-w 2020
Patient treatment and outcome after breast cancer orbital and periorbital metastases: a comprehensive case series including analysis of lobular versus ductal tumor histology [0.03%]
乳腺癌眼眶和眶周转移患者的治疗及预后：一项全面的病例系列分析，包括小叶癌与导管癌组织学结果的对比分析
Martin Blohmer,Li Zhu,Jennifer M Atkinson et al.
Martin Blohmer et al.
Background: Breast cancer is the most common malignancy to spread to the orbit and periorbit, and the invasive lobular carcinoma (ILC) histologic subtype of breast cancer has been reported to form these ophthalmic metasta...
New generation breast cancer cell lines developed from patient-derived xenografts [0.03%]
从患者来源异种移植瘤中研发的新一代乳腺癌细胞系
Jessica Finlay-Schultz,Britta M Jacobsen,Duncan Riley et al.
Jessica Finlay-Schultz et al.
Background: Breast cancer is a highly heterogeneous disease characterized by multiple histologic and molecular subtypes. While a myriad of breast cancer cell lines have been developed over the past 60 years, estrogen rece...
Comparison of three scoring methods using the FDA-approved 22C3 immunohistochemistry assay to evaluate PD-L1 expression in breast cancer and their association with clinicopathologic factors [0.03%]
基于FDA批准的22C3免疫组织化学检测评估乳腺癌PD-L1表达的三种评分方法比较及其与临床病理因素的关系
Hua Guo,Qingqing Ding,Yun Gong et al.
Hua Guo et al.
Background: In the evaluation of PD-L1 expression to select patients for anti-PD-1/PD-L1 treatment, uniform guidelines that account for different immunohistochemistry assays, different cell types and different cutoff valu...
Comparative Study
Breast cancer research : BCR. 2020 Jun 23;22(1):69. DOI:10.1186/s13058-020-01303-9 2020
Effects of tumor-specific CAP1 expression and body constitution on clinical outcomes in patients with early breast cancer [0.03%]
肿瘤特异性CAP1表达和体质对早期乳腺癌患者临床结局的影响
Malin Bergqvist,Karin Elebro,Malte Sandsveden et al.
Malin Bergqvist et al.
Background: Obesity induces molecular changes that may favor tumor progression and metastatic spread, leading to impaired survival outcomes in breast cancer. Adenylate cyclase-associated protein 1 (CAP1), an actin regulat...
KLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene [0.03%]
KLF4通过抑制EGFR基因定义了表皮生长因子受体抑制剂厄洛替尼在三阴性乳腺癌细胞中的疗效
Melyssa S Roberts,Lindsey J Anstine,Viviane S Finke et al.
Melyssa S Roberts et al.
Background: Triple-negative breast cancer (TNBC) is characterized by high rates of recurrence and poor overall survival. This is due, in part, to a deficiency of targeted therapies, making it essential to identify therape...
Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer [0.03%]
非洲裔美国女性和白人乳腺癌患者乳腺脂肪组织中检测到冠状结构及其临床转归
Maret L Maliniak,Aswathy Miriam Cheriyan,Mark E Sherman et al.
Maret L Maliniak et al.
Background: Crown-like structures in breast adipose tissue (CLS-B), composed of necrotic adipocytes encircled by macrophages, are associated with obesity and hypothesized to worsen breast cancer prognosis; however, data a...
Age-associated genes in human mammary gland drive human breast cancer progression [0.03%]
与人类乳腺癌进展相关的年龄基因
Xiang Gu,Bingzhi Wang,Haiyan Zhu et al.
Xiang Gu et al.
Background: Aging is a comorbidity of breast cancer suggesting that aging-associated transcriptome changes may promote breast cancer progression. However, the mechanism underlying the age effect on breast cancer remains p...
Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer [0.03%]
基底样乳腺癌中抑制分化4（ID4）的蛋白质基因组分析
Laura A Baker,Holly Holliday,Daniel Roden et al.
Laura A Baker et al.
Background: Basal-like breast cancer (BLBC) is a poorly characterised, heterogeneous disease. Patients are diagnosed with aggressive, high-grade tumours and often relapse with chemotherapy resistance. Detailed understandi...