A risk-associated Active transcriptome phenotype expressed by histologically normal human breast tissue and linked to a pro-tumorigenic adipocyte population [0.03%]
与肿瘤风险相关的正常人乳腺组织的活性转录组特征，并且与一种促肿瘤脂肪细胞群相关联
Taekyu Kang,Christina Yau,Christopher K Wong et al.
Taekyu Kang et al.
Background: Previous studies have identified and validated a risk-associated Active transcriptome phenotype commonly expressed in the cancer-adjacent and histologically normal epithelium, stroma, and adipose containing pe...
Kelsey F Ruud,William C Hiscox,Ilhan Yu et al.
Kelsey F Ruud et al.
Background: Breast cancer cells invading the connective tissues outside the mammary lobule or duct immerse in a reservoir of extracellular matrix (ECM) that is structurally and biochemically distinct from that of their si...
Identification and targeting of selective vulnerability rendered by tamoxifen resistance [0.03%]
他莫昔芬耐药导致的选择性脆弱性的识别和靶向处理
Madhurendra Singh,Xiaolei Zhou,Xinsong Chen et al.
Madhurendra Singh et al.
Background: The estrogen receptor (ER)-positive breast cancer represents over 80% of all breast cancer cases. Even though adjuvant hormone therapy with tamoxifen (TMX) is saving lives of patients with ER-positive breast c...
BRCAness digitalMLPA profiling predicts benefit of intensified platinum-based chemotherapy in triple-negative and luminal-type breast cancer [0.03%]
用于预测三阴性和激素受体阳性乳腺癌强化以铂类药物为基础的化疗疗效的BRCAness数字MLPA检测
Esther H Lips,Anne Benard-Slagter,Mark Opdam et al.
Esther H Lips et al.
Background: We previously showed that BRCA-like profiles can be used to preselect individuals with the highest risk of carrying BRCA mutations but could also indicate which patients would benefit from double-strand break ...
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study [0.03%]
红细胞膜脂肪酸与乳腺癌的发病风险及其与肿瘤组织免疫炎症标志物和脂肪酸合酶表达之间的关系：一项病例对照研究
Emma E McGee,Claire H Kim,Molin Wang et al.
Emma E McGee et al.
Background: Previous studies of fatty acids and breast cancer risk have shown mixed results, which may be due in part to tumor heterogeneity. Prior research has also illustrated an important role of specific fatty acids i...
Neoadjuvant endocrine therapy in locally advanced estrogen or progesterone receptor-positive breast cancer: determining the optimal endocrine agent and treatment duration in postmenopausal women-a literature review and proposed guidelines [0.03%]
绝经后女性局部晚期乳腺癌新辅助内分泌治疗药物选择和疗程时间的文献回顾及推荐意见
Lauren I Madigan,Phuong Dinh,J Dinny Graham
Lauren I Madigan
Introduction: For patients with locally advanced estrogen receptor or progesterone receptor-positive breast cancer, neoadjuvant endocrine therapy (NET) facilitates down-staging of the tumor and increased rates of breast-c...
A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer [0.03%]
早期乳腺癌 Luminal 亚型中活化成纤维细胞的一个亚群与远处复发相关
Claire Bonneau,Antoine Eliès,Yann Kieffer et al.
Claire Bonneau et al.
Background: Early luminal breast cancer (BC) represents 70% of newly diagnosed BC cases. Among them, small (under 2 cm) BC without lymph node metastasis (classified as T1N0) have been rarely studied, as their prognosis is...
Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression [0.03%]
孕激素膜受体组分1调节脂质稳态并驱动致癌信号传导导致乳腺癌进展
Hannah Asperger,Nadia Stamm,Berthold Gierke et al.
Hannah Asperger et al.
Background: PGRMC1 (progesterone receptor membrane component 1) is a highly conserved heme binding protein, which is overexpressed especially in hormone receptor-positive breast cancer and plays an important role in breas...
Superior breast cancer metastasis risk stratification using an epithelial-mesenchymal-amoeboid transition gene signature [0.03%]
利用上皮间充质变形虫样过渡基因特征改善乳腺癌转移风险分类
Amin Emad,Tania Ray,Tor W Jensen et al.
Amin Emad et al.
Background: Cancer cells are known to display varying degrees of metastatic propensity, but the molecular basis underlying such heterogeneity remains unclear. Our aims in this study were to (i) elucidate prognostic subtyp...
Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltration [0.03%]
分泌型乳腺肿瘤间质液微小核糖核酸及其靶基因与三阴性乳腺癌、肿瘤分级和免疫浸润相关性研究
Thilde Terkelsen,Francesco Russo,Pavel Gromov et al.
Thilde Terkelsen et al.
Background: Studies on tumor-secreted microRNAs point to a functional role of these in cellular communication and reprogramming of the tumor microenvironment. Uptake of tumor-secreted microRNAs by neighboring cells may re...