Fibroblasts direct differentiation of human breast epithelial progenitors [0.03%]
成纤维细胞指导人类乳腺上皮前体细胞的分化
Mikkel Morsing,Jiyoung Kim,René Villadsen et al.
Mikkel Morsing et al.
Background: Breast cancer arises within specific regions in the human breast referred to as the terminal duct lobular units (TDLUs). These are relatively dynamic structures characterized by sex hormone driven cyclic epith...
Mammographic density change in a cohort of premenopausal women receiving tamoxifen for breast cancer prevention over 5 years [0.03%]
接受他莫昔芬预防乳腺癌五年内绝经前女性乳房密度的变化
Adam R Brentnall,Ruth Warren,Elaine F Harkness et al.
Adam R Brentnall et al.
Background: A decrease in breast density due to tamoxifen preventive therapy might indicate greater benefit from the drug. It is not known whether mammographic density continues to decline after 1 year of therapy, or whet...
Outdoor air pollution and terminal duct lobular involution of the normal breast [0.03%]
室外空气污染与正常乳腺终末导管小叶单位退化的关系
Nicole M Niehoff,Alexander P Keil,Rena R Jones et al.
Nicole M Niehoff et al.
Background: Exposure to certain outdoor air pollutants may be associated with a higher risk of breast cancer, though potential underlying mechanisms are poorly understood. We examined whether outdoor air pollution was ass...
Independent and joint cross-sectional associations of statin and metformin use with mammographic breast density [0.03%]
他汀类和二甲双胍单独或联合使用与乳房X线照片致密性关系的横断面研究
Erica J Lee Argov,Teofilia Acheampong,Mary Beth Terry et al.
Erica J Lee Argov et al.
Background: Well-tolerated and commonly used medications are increasingly assessed for reducing breast cancer risk. These include metformin and statins, both linked to reduced hormone availability and cell proliferation o...
Plasma thymidine kinase 1 activity and outcome of ER+ HER2- metastatic breast cancer patients treated with palbociclib and endocrine therapy [0.03%]
血浆脱氧核苷酸激酶1活性与ER阳性HER2阴性转移性乳腺癌患者接受Palbociclib和内分泌治疗的疗效的关系
Luc Cabel,Dan Rosenblum,Florence Lerebours et al.
Luc Cabel et al.
Purpose: Previous cohort studies have reported plasma TK1 activity (pTKa) as a potential prognostic biomarker in estrogen receptor-positive (ER+) HER2-negative (HER2-) metastatic breast cancer (MBC). In this prospective s...
A phase 1b study evaluating the effect of elacestrant treatment on estrogen receptor availability and estradiol binding to the estrogen receptor in metastatic breast cancer lesions using 18F-FES PET/CT imaging [0.03%]
使用18F-FES PET / CT成像评估elacestrant治疗对转移性乳腺癌病灶中雌激素受体可用性和雌二醇结合到雌激素受体的影响的Ib期研究
Agnes Jager,Elisabeth G E de Vries,C Willemien Menke-van der Houven van Oordt et al.
Agnes Jager et al.
Background: Elacestrant is an oral selective estrogen receptor (ER) degrader. This phase 1b open-label, non-randomized study (RAD1901-106) was initiated to determine the effect of elacestrant on the availability of ER in ...
Kimberly A Bertrand,Traci N Bethea,Hanna Gerlovin et al.
Kimberly A Bertrand et al.
Background: Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of breast cancer; however, results of epidemiological studies have been mixed. F...
Marike Gabrielson,Shadi Azam,Elina Hardell et al.
Marike Gabrielson et al.
Background: Mammographic density (MD) is a strong risk factor for breast cancer. We examined how endogenous plasma hormones are associated with average MD area (cm2) and annual MD change (cm2/year). ...
MRI background parenchymal enhancement, fibroglandular tissue, and mammographic breast density in patients with invasive lobular breast cancer on adjuvant endocrine hormonal treatment: associations with survival [0.03%]
辅助内分泌激素治疗的侵袭性小叶乳腺癌患者的MRI背景实质强化，纤维腺体组织和乳房X线照片的乳房密度与生存率的关系
Roberto Lo Gullo,Isaac Daimiel,Carolina Rossi Saccarelli et al.
Roberto Lo Gullo et al.
Background: To investigate if baseline and/or changes in contralateral background parenchymal enhancement (BPE) and fibroglandular tissue (FGT) measured on magnetic resonance imaging (MRI) and mammographic breast density ...
Impact of a ketogenic diet intervention during radiotherapy on body composition: III-final results of the KETOCOMP study for breast cancer patients [0.03%]
放射治疗期间酮体饮食干预对身体成分的影响：乳腺癌患者的KETOCOMP研究最终结果第三部分
Rainer J Klement,Colin E Champ,Ulrike Kämmerer et al.
Rainer J Klement et al.
Background: Obesity and low muscle mass are associated with worse outcomes of breast cancer patients. We conducted a controlled trial to study the impact of a ketogenic diet (KD) based on natural foods versus an unspecifi...