Caution over haste: why novel endocrine therapy in early lines should wait in Estrogen receptor positive human epidermal growth factor receptor 2 negative breast cancer [0.03%]
ER阳性HER2阴性乳腺癌早期治疗应谨慎使用新型内分泌治疗
Lan Lei,Manali Bhave,Kevin Kalinsky et al.
Lan Lei et al.
TRPS1 confers paclitaxel resistance in TNBC through dual activation of the PDE4D-cAMP-AKT pathway and microtubule destabilization [0.03%]
TRPS1通过双重激活PDE4D-cAMP-AKT通路和微管解聚赋予三阴性乳腺癌顺式枯烯耐药性
Xin He,Wanting Tong,Xinyan Chen et al.
Xin He et al.
Characterization of ESR1 alterations in patients with breast and gynecologic cancers [0.03%]
乳腺和妇科癌症患者中ESR1突变的特征分析
Gargi D Basu,Paige E Innis,Angela K Deem et al.
Gargi D Basu et al.
Background: ESR1 alterations present a common mechanism of resistance to endocrine therapy (ET) in hormonally driven tumors. The clinical significance of these alterations continues to evolve with newly approved targeted ...
[225Ac]Ac-labeled matuzumab is an effective radioimmunotherapeutic against EGFR-positive triple negative breast cancer [0.03%]
标记的马妥珠单抗针对表皮生长因子受体阳性三阴性乳腺癌的放射免疫治疗有效
Anjong Florence Tikum,Dede Api Fon,Fabrice Ngoh Njotu et al.
Anjong Florence Tikum et al.
Background: EGFR is overexpressed in TNBC, and "naked" anti-EGFR monoclonal antibodies have been evaluated in clinical trials with dismal effectiveness. Matuzumab is an anti-EGFR monoclonal antibody that can be used to de...
Estrogen metabolism pathways in pregnancy and subsequent breast cancer risk: a prospective follow-up study [0.03%]
妊娠期间的雌激素代谢途径与嗣后乳腺癌风险的相关性：一项前瞻性队列研究
R Troisi,R T Falk,H M Surcel et al.
R Troisi et al.
Background: In the years following pregnancy, breast cancer risk is elevated, particularly for hormone receptor negative (HR-) tumors. Exposure to high maternal circulating estrogens, when the breast is vastly remodeling ...
CRYβB2 is a biomarker for poor prognosis and response to CDK4/6 inhibitors in breast cancer [0.03%]
CRYβB2是乳腺癌预后不良和对CDK4/6抑制剂无响应的生物标志物
Yu Yan,Athira Narayan,Marzieh Mazinani et al.
Yu Yan et al.
Putative breast cancer risk variants from populations of South Asian ancestry are under-represented in public variant classification databases [0.03%]
来自南亚人群的乳腺癌风险变异位点在公共变异分类数据库中代表性不足
Raveen Rony,Shenglong Deng,Sarah Yang et al.
Raveen Rony et al.
The majority of publicly available genomics data originates from populations of European ancestry. This limits understanding and detection of inherited genetic risk factors for breast cancer in other populations. To assess the extent to whi...
Multiomic profiling of ER-positive HER2-negative breast cancer reveals markers associated with metastatic spread [0.03%]
ER阳性HER2阴性乳腺癌的多组学谱分析揭示了与转移相关的标志物
Sergio Mosquim Junior,Måns Zamore,Johan Vallon-Christersson et al.
Sergio Mosquim Junior et al.
Background: Metastatic disease is the main cause of breast cancer (BC)-related deaths, but prediction of metastases remains challenging especially in the large and diverse group with estrogen receptor (ER)-positive, human...
Spatial and temporal dynamics of cancer-associated fibroblast niches in breast cancer [0.03%]
乳腺癌相关成纤维细胞生态位的时空动态变化研究
Jessica Pantaleo,Jonas Sjölund,Paulina Bolivar et al.
Jessica Pantaleo et al.
Plasma extracellular vesicles reflect response and prognosis in patients with breast cancer undergoing neoadjuvant treatment [0.03%]
术前新辅助治疗的乳腺癌患者血浆外泌体反映患者的反应和预后
Karin Ekström,Nazia Riaz,Karolina Larsson et al.
Karin Ekström et al.