Associations of early-adulthood adiposity with breast parenchymal tissue complexity within premenopausal women [0.03%]
体重与乳腺实质组织复杂度的关联性研究
Sneha Das Gupta,Kayla Getz,Juanita Hernandez Lopez et al.
Sneha Das Gupta et al.
Background: Early-adulthood adiposity is associated with breast cancer risk. This study aims to evaluate the associations of early-adulthood adiposity with an emerging biomarker of breast cancer risk, breast parenchymal c...
Multi-receptor targeted therapy of breast cancer and brain metastases with a novel QUAD-drug conjugate [0.03%]
用于乳腺癌和脑转移的新型QUAD-药物缀合物多受体靶向疗法
Waldemar Debinski,Kaitlin N Fink,John Rossmeisl et al.
Waldemar Debinski et al.
Background: Identifying treatments for triple-negative breast cancer (TNBC) remains a critical medical need. We have found that Interleukin 13 receptor alpha 2 (IL-13RA2), EphA2, EphA3 and EphB2 receptors are over-express...
The nonsteroidal anti-inflammatory drug sulindac reverses obesity-driven immunosuppression and triple-negative breast cancer progression [0.03%]
非甾体抗炎药硫吲哚昔逆转肥胖驱动的免疫抑制和三阴性乳腺癌进展
Michael F Coleman,Shannon B McDonell,Lydia K Eisenbeis et al.
Michael F Coleman et al.
Obesity affects over 40% of women in the US and increases the risk and progression of several cancers, including triple-negative breast cancer (TNBC), in part through chronic low-grade inflammation and impaired antitumor immunity. While wei...
Mammographic density and breast cancer pathological subtypes by menopausal status and body mass index [0.03%]
绝经状态和体重指数对乳腺癌病理亚型及乳腺密度的影响
Julia Fernández-Morata,Marina Pollán,Nerea Fernández de Larrea-Baza-Baz et al.
Julia Fernández-Morata et al.
Background: Mammographic density (MD) is an established biomarker of breast cancer (BC) risk. However, its relationship to BC pathological subtypes remains unclear. This study aimed to investigate this association and ass...
Deep learning-powered multi-parametric ultrasound for classifying metastatic versus reactive axillary lymph nodes [0.03%]
基于深度学习的多参数超声鉴别腋窝转移淋巴结与反应性淋巴结
Manali Saini,Tanin Adl Parvar,Claire Graham et al.
Manali Saini et al.
Purpose: To propose a multi-parametric ultrasound imaging-based deep learning method for accurately classifying metastatic and non-metastatic axillary lymph nodes in breast cancer patients. ...
Correction: Comparative efficacy of first- versus second-line CDK4/6 Inhibition in hormone receptor-positive, HER2-negative metastatic breast cancer [0.03%]
关于雌激素受体阳性、HER2阴性转移性乳腺癌患者一线与二线使用CDK4/6抑制剂疗效的比较：一项对发表数据进行再分析的研究 纠正公告
Victoria Lis Ravani,Zahra Bagheri,Adam M Brufsky et al.
Victoria Lis Ravani et al.
Published Erratum
Breast cancer research : BCR. 2025 Oct 23;27(1):183. DOI:10.1186/s13058-025-02154-y 2025
Modulating phosphodiesterase-5 activity to suppress the immunosuppressive mechanisms of myeloid-derived suppressor cells in breast cancer [0.03%]
调节磷酸二酯酶-5活性以抑制乳腺癌中髓系来源的抑制性细胞的免疫抑制机制
Yingxue Guo,Mengyun Chen,Qi Yuan et al.
Yingxue Guo et al.
Phosphodiesterase-5 (PDE5) inhibitors have been shown to have potential as an adjuvant therapy for cancer. Tadalafil is a potent and selective PDE5 inhibitor that has been shown to inhibit the aggregation of myeloid-derived suppressor cells...
Morphological analysis of tumor microenvironment in HER2-positive breast cancer: predicting response to neoadjuvant chemotherapy on histopathological images [0.03%]
HER2阳性乳腺癌肿瘤微环境的形态学分析：基于病理图像预测新辅助化疗的疗效
Wensheng Cui,Ming Fan,Lihua Li
Wensheng Cui
Background: HER2-positive breast cancer (HER2 + BC) is clinically distinct from other subtypes, such as triple-negative or hormone receptor–positive breast cancers, due to its unique tumor microenvironment (TME) and its ...
Spatial analysis of tumor immune microenvironment of TNBC with different neoadjuvant chemotherapy outcomes using multiplex Immunofluorescence [0.03%]
多重免疫荧光技术对不同新辅助化疗结果的三阴性乳腺癌肿瘤免疫微环境的空间分析
Inho Park,Su-Jin Shin,Heounjeong Go et al.
Inho Park et al.
Background: Triple-negative breast cancer (TNBC) is characterized by aggressive biological behavior and poor prognosis. However, TNBC exhibits higher immunogenicity than other breast cancer subtypes, making it more respon...
The role of NETosis in breast cancer: mechanistic insights and biomarker potential [0.03%]
乳腺癌中NETosis的作用：机制见解和生物标志物潜力
Fahimeh Norouzi,Pooya Eini,Safa Tahmasebi
Fahimeh Norouzi
Neutrophil extracellular trap formation (NETosis), previously described as an effector host defense mechanism, is more frequently associated with cancer-driven inflammation and tumor development. In the case of breast cancer, NETosis assist...