Integrative multi-omics reveals common and distinct pathogenic mechanisms and preoperative diagnostic signatures in breast fibroepithelial lesions [0.03%]
整合多组学揭示了乳腺纤维上皮性病变中的常见和特异性发病机制及术前诊断标志物
Ming He,Kai Song,Yun Luo et al.
Ming He et al.
Breast fibroepithelial lesions (FELs) comprising fibroadenomas (FAs) and phyllodes tumors (PTs) with varying degrees of malignancy, necessitate tailored surgical approaches. However, preoperative diagnosis of FELs remains challenging and th...
Attention-based multimodal fusion transformer for predicting the efficacy of neoadjuvant therapy in breast cancer: a cross-institutional retrospective study [0.03%]
基于注意力的多模态融合变压器预测乳腺癌新辅助治疗疗效：一项跨机构回顾性研究
Wenchuan Zhang,Shuwan Zhang,Jiadi You et al.
Wenchuan Zhang et al.
Background: Neoadjuvant therapy (NAC) is a standard treatment for breast cancer, yet only some patients gain significant benefit. Identifying those most likely to benefit from NAC is crucial. Single-modality data often ov...
Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-ϒ reprograms tumor-associated macrophages to suppress triple negative breast cancer [0.03%]
靶向分泌型Frizzled相关蛋白2的单克隆抗体通过重编程肿瘤相关巨噬细胞抑制三阴性乳腺癌
Lillian Hsu,Julie Siegel,Patrick Nasarre et al.
Lillian Hsu et al.
Purpose: We hypothesize that SFRP2 is a promising target for Triple Negative Breast Cancer (TNBC). Experimental design: 1. Multiplex im...
18F-Fluorodeoxyglucose PET-CT evaluation after one course of neoadjuvant therapy fails to predict pCR in HER2 + BC patients: a prospective and multicentric French study [0.03%]
18F-氟脱氧葡萄糖正电子发射断层扫描-X线计算机体层成像评估新辅助治疗一个疗程后HER2阳性乳腺癌患者的pCR预测价值：一项前瞻性多中心法国研究
M Chanchou,M A Mouret-Reynier,I Molnar et al.
M Chanchou et al.
Background: 18F-FDG PET-CT has emerged as a powerful imaging tool for initial staging and prognosis evaluation of patients with Breast Cancer (BC). However, previous studies are inconsistent on attributing a predictive va...
Breast cancer risk during oral contraceptive use in women with high polygenic risk [0.03%]
高多基因风险女性口服避孕药期间患乳腺癌的风险
Christina Chatsatourian,Valeria Lo Faro,Torgny Karlsson et al.
Christina Chatsatourian et al.
Pathological response to pembrolizumab-based neoadjuvant therapy in ER-low vs. ER-zero breast cancer: a Swedish population-based cohort study [0.03%]
基于派姆单抗的新辅助治疗在ER低表达与ER零表达乳腺癌中的病理性反应：一项瑞典人群队列研究
Sanna Steen,Emelie Karlsson,Ida Björnheden et al.
Sanna Steen et al.
Background: Emerging evidence indicates that estrogen receptor-low (ER-low)/human epidermal growth factor receptor 2 negative (HER2-) breast cancer (BC) may more closely resemble ER-negative (ER-zero, < 1%) rather than ER...
Evaluation of short-course durvalumab combined with dose-dense EC in the neoadjuvant setting for locally advanced luminal B/HER2(-) or triple-negative breast cancer [0.03%]
度伐利尤单抗联合密集多西他赛和表柔比星新辅助治疗局部晚期 Luminal B型/HER2阴性和三阴性乳腺癌的疗效评估
Alix Devaux,Gabriela Beniuga,Paul Delrée et al.
Alix Devaux et al.
Background: Combining immune checkpoint inhibitors (ICI) with neoadjuvant chemotherapy (NACT) has been the standard of care for stage II and III triple negative breast cancer (TNBC) since 2021. For Luminal B/HER2(-) breas...
Macrophages in obesity-related breast cancer: mechanistic insights and therapeutic opportunities [0.03%]
肥胖相关乳腺癌的巨噬细胞：机制见解和治疗机会
Huiyu Dong,Ming Zhou,Qin Sun et al.
Huiyu Dong et al.
Obesity has emerged as a global public health crisis, significantly increasing susceptibility to malignancies, including breast cancer. In the context of Obesity-Related Breast Cancer (ORBC), the abundant adipose tissue in the mammary gland...
CAND1 mediates CUL7-dependent HER2 protein stability to drive breast cancer progression [0.03%]
CAND1通过介导CUL7依赖性的HER2蛋白稳定性来促进乳腺癌的进展
Xiaohong Xia,Xiaoyue He,Mengfan Tang et al.
Xiaohong Xia et al.
Background: HER2-positive breast cancer is a prevalent pathological subtype of breast cancer. Resistance to anti-HER2 targeted therapies remains a significant challenge in treatment. Understanding the role of HER2 in brea...
Perceived racial discrimination in health care in relation to late stage at breast cancer diagnosis [0.03%]
种族歧视与乳腺癌晚期诊断的关系
Nuo N Xu,Mollie E Barnard,Etienne X Holder et al.
Nuo N Xu et al.
Background: In the U.S., poorer breast cancer survival in Black women relative to white women has persisted for over 30 years, with recent data showing a 38% higher mortality in Black women with breast cancer. Stage at di...