Histologic correlates of background parenchymal uptake on molecular breast imaging [0.03%]
分子乳腺显像中背景实质摄取的组织病理学相关性研究
Lydia Bardwell Speltz,Karthik Ghosh,Daniel W Visscher et al.
Lydia Bardwell Speltz et al.
Background: Molecular breast imaging (MBI) has shown utility as a supplement to mammography in women with dense breasts. Background parenchymal uptake (BPU), which describes the level of Tc-99 m sestamibi in fibroglandula...
Observational Study
Breast cancer research : BCR. 2025 Dec 16;27(1):216. DOI:10.1186/s13058-025-02171-x 2025
MAP3K1/MAP2K4 mutations drive breast cancer progression by compensating for TP53 loss through inactivation of the JNK2-p53-FOSL1 axis [0.03%]
MAP3K1/MAP2K4突变通过使JNK2-p53-FOSL1轴失活来驱动三阴性乳腺癌的进展以补偿TP53丢失的作用
Sike Hu,Ailing Ji,Manxue Wang et al.
Sike Hu et al.
Background: Cancer progression is driven by somatic mutations, with alterations in driver genes such as tumor suppressors and oncogenes playing critical roles. In breast cancer (BRCA), mutations in MAP3K1 and MAP2K4 are r...
Tumor-educated-platelets interact with breast cancer-stem-cells via P-selectin-PSGL1 and ensure stemness and metastasis through WNT-β-catenin-VEGF-VEGFR2 intra-cellular signaling: therapeutic modulation by aspirin [0.03%]
肿瘤来源血小板通过P-选择素与白念珠菌干细胞型细胞互作并通过WNT-β-catenin-VEGF-VEGFR2信号维持干性并促进转移：乙酰水杨酸的治疗作用
Aishwarya Guha,Jasmine Sultana,Avishek Bhuniya et al.
Aishwarya Guha et al.
Background: Protagonistic role of platelets promote capillary infiltration of tumors for distant metastasis along with immunosurveillance. Despite existing reports highlighting role of platelets in tumorigenesis, its impa...
Metformin and its derivatives in breast cancer: from glycaemic control to tumor-intrinsic pathways [0.03%]
二甲双胍及其衍生物在乳腺癌中的应用：从血糖控制到肿瘤固有通路
Rohina Alim,Hewa Marambage Kasuni Akalanka
Rohina Alim
Background: Breast cancer (BC) remains the most commonly diagnosed malignancy among women worldwide, with metabolic dysregulation of glucose and hyperinsulinemia increasingly recognised as contributors to its development ...
Nuclear PD-L1 drives IFN-γ-promoted lung metastasis of triple-negative breast cancer via POLR2A-mediated transcriptional activation of LY6E [0.03%]
核PD-L1通过POLR2A介导的LY6E转录激活促进IFN-γ驱动的三阴性乳腺癌肺转移
Xu Wang,Qi Zhou,Pu Wang et al.
Xu Wang et al.
Background: Triple-negative breast cancer (TNBC) patients exhibiting high PD-L1 expression demonstrate poor responses to anti-PD-L1 therapy and aggressive lung metastasis. The paradoxical role of PD-L1 beyond its immu...
Prognostic value of baseline FDG PET/CT in HER2-positive metastatic breast cancer treated with first-line trastuzumab, pertuzumab, and docetaxel [0.03%]
基线FDG PET/CT在HER2阳性转移性乳腺癌一线曲妥珠单抗、帕妥珠单抗和多西他赛治疗中的预测价值
Marcin Kubeczko,Andrea d&#x;Amico,Olgierd Chrabanski et al.
Marcin Kubeczko et al.
Retrospective review of metastatic hormone receptor-positive inflammatory breast cancer patients reveals poor responses to cyclin dependent kinase 4/6 inhibition [0.03%]
回顾性分析激素受体阳性炎性乳腺癌转移患者的资料，发现对细胞周期素依赖性激酶4/6抑制剂的反应较差
Azadeh Nasrazadani,Rebecca S Tidwell,Megumi Kai et al.
Azadeh Nasrazadani et al.
Background: Patients with inflammatory breast cancer (IBC) have aggressive biology and relatively inferior responses to standard-of-care (SOC) therapies. Understanding the efficacy of SOC therapies in IBC is critical to o...
Modelling the metastatic immune microenvironment in triple-negative breast cancer [0.03%]
三阴性乳腺癌转移免疫微环境的建模研究
Laura Rodriguez de la Fuente,Andrew M K Law,Laura Rangel-Sanchez et al.
Laura Rodriguez de la Fuente et al.
Background: This study uses the well-established 4T1.2 and 67NR mammary cancer cell lines as syngeneic immunocompetent implantable murine models of triple negative breast cancer. ...
Multidimensional cell-free DNA fragmentomics enables early detection of breast cancer [0.03%]
多维度细胞游离DNA片段组学可实现乳腺癌的早期检测
Lixian Yang,Mengyang An,Heng Song et al.
Lixian Yang et al.
Background: Cell-free DNA (cfDNA) fragmentomics represents a transformative approach for early breast cancer detection, offering significant potential to improve patient survival through timely intervention. Despite this ...
APOBEC3B protein expression associates with poor prognosis for breast cancer patients with ER-positive disease [0.03%]
APOBEC3B蛋白表达与雌激素受体阳性乳腺癌患者的不良预后相关
Maartje A C Schreurs,A Mieke Timmermans,Michael A Carpenter et al.
Maartje A C Schreurs et al.