RNAi in arthritis: prospects of a future antisense therapy in inflammation [0.03%]
RNA干扰在关节炎治疗中的应用：作为炎症靶向疗法的前景
Maroun Khoury,Christian Jorgensen,Florence Apparailly
Maroun Khoury
Rheumatoid arthritis is a chronic autoimmune disease of unknown etiology that is characterized by chronic systemic inflammation, mainly affecting the joints, leading to subsequent destruction of the cartilage and bone. RNA interference (RNA...
Elena Favaro,Stefano Indraccolo
Elena Favaro
The field of gene therapy offers promising treatment innovations that may prove to be fundamental in helping cancer patients. In this review, recent advances in this field are discussed, with particular emphasis on new trends that have emer...
Oral cancer proteomics [0.03%]
口腔癌蛋白质组学研究
Shen Hu,David T Wong
Shen Hu
Proteomics is a novel molecular profiling technology that may significantly accelerate human cancer research. This review summarizes recent progress in oral cancer proteomics and discusses potential applications in this emerging field. With...
Recent advances in the development of oncolytic HSV-1 vectors: 'arming' of HSV-1 vectors and application of bacterial artificial chromosome technology for their construction [0.03%]
近年溶瘤HSV-1载体开发进展：“武装”HSV-1载体及利用细菌人工染色体技术构建HSV-1载体
Deva S Jeyaretna,Toshihiko Kuroda
Deva S Jeyaretna
HSV-1 was one of the first oncolytic viruses to have been investigated for its therapeutic potential against cancer. Among the dozens of oncolytic HSV-1 vectors that have so far been reported, some carry transgenes, including interleukins, ...
Lentivirus as a potent and mechanistically distinct vector for genetic immunization [0.03%]
慢病毒：一种有效的遗传免疫载体及其独特的作用机制
Yukai He,Louis D Falo Jr
Yukai He
T-cell-mediated immunity is critical for the prevention and control of a broad range of infectious diseases and human malignancies. Genetic immunization is a promising approach for the elicitation of T-cell immunity. Recombinant lentivector...
Fetal gene transfer [0.03%]
胎儿基因转移技术
Simon N Waddington,Suzanne Mk Buckley,Anna L David et al.
Simon N Waddington et al.
Gene transfer early in development for the treatment of monogenetic and other diseases could overcome major obstacles of intervention in the mature individual. Early gene transfer may prevent the onset of irreversible pathological changes, ...
Viggo F I Van Tendeloo,Peter Ponsaerts,Zwi N Berneman
Viggo F I Van Tendeloo
In the field of nonviral gene therapy, mRNA-based gene transfer has generated much interest over the last decade. The combination of RNA as a versatile protein delivery molecule and the dendritic cell as the most potent antigen-presenting c...
Linaclotide, a new direction in the treatment of irritable bowel syndrome and chronic constipation [0.03%]
利那洛肽：难治性肠易激综合征和慢性便秘治疗的新方向
Lucinda A Harris,Michael D Crowell
Lucinda A Harris
Microbia Inc is developing the oral guanylate cyclase C agonist linaclotide, a 14mer peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation. Phase II clinical trials are ...
MBP-8298, a synthetic peptide analog of myelin basic protein for the treatment of multiple sclerosis [0.03%]
一种治疗多发性硬化的合成肽类物质MBP-8298
Cynthia Darlington
Cynthia Darlington
BioMS Medical Corp, under license from the University of Alberta, is developing MBP-8298, a synthetic peptide analog of myelin basic protein, for the potential treatment of multiple sclerosis. Phase II and III clinical trials of MBP-8298 ar...
Zhiming Han,Catherine A Vandevoort,Keith E Latham
Zhiming Han
Embryonic stem cells (ESCs) offer a new and remarkable potential for treating and curing a wide range of genetic diseases such as diabetes and muscular dystrophy, degenerative diseases such as Parkinson's disease, renal disease and heart di...