An update on lipidomics: progress and application in biomarker and drug development [0.03%]
脂质组学研究进展及其在生物标志物和药物研发中的应用
Xianlin Han
Xianlin Han
Substantial progress has been made in the application of lipidomics in biomarker discovery and drug development, as well as in a variety of other areas. In particular, the number of published studies reporting the quantitation and analysis ...
NMR-based metabolomics: translational application and treatment of cancer [0.03%]
基于核磁共振代谢组学的癌症转化应用及治疗研究
Natalie J Serkova,Jennifer L Spratlin,S Gail Eckhardt
Natalie J Serkova
Cancer cells possess a highly unique metabolic phenotype which is characterized by high glucose uptake, increased glycolytic activity, decreased mitochondrial activity, low bioenergetic expenditure and increased phospholipid turnover. In ad...
Kewal K Jain
Kewal K Jain
Cancer biomarkers and characteristics of an ideal biomarker for cancer are discussed in this review, as well as technologies for their detection. The focus of this article is on the use of biomarkers for anticancer drug development and clin...
Maja Cemazar,Gregor Sersa
Maja Cemazar
Electroporation is a physical method for the delivery of various molecules into cells by application of controlled external electrical fields that transiently increase permeability of the cell membrane. This technique is now widely used as ...
Alice C Rodrigues,Mário H Hirata,Rosario D C Hirata
Alice C Rodrigues
The statins or HMG-CoA reductase inhibitors are considered one of the most effective classes of drugs for reducing LDL and total cholesterol. Although, statin treatment has beneficial effects in the prevention of cardiovascular disease, con...
Smoking behavior and related cancers: the role of CYP2A6 polymorphisms [0.03%]
吸烟行为及相关的癌症：CYP2A6多态性所起的作用
Miki Nakajima
Miki Nakajima
Smoking exerts complex central and peripheral nervous system, behavioral, cardiovascular, and endocrine effects in humans and is a primary risk factor for various cancers. Nicotine, a major constituent of tobacco, is the compound that is re...
Njira L Lugogo,Geoffrey S Ginsburg,Loretta G Que
Njira L Lugogo
Asthma is characterized by reversible bronchial hyper-responsiveness and airway inflammation, and encompasses a wide variety of patients with different clinical phenotypes that display variable responses to therapy. The definition of genomi...
Tremelimumab, a fully human monoclonal IgG2 antibody against CTLA4 for the potential treatment of cancer [0.03%]
特尔莫利姆单抗，一种针对CTLA4的人类免疫球蛋白G2单克隆抗体，用于癌症的潜在治疗研究中
Ahmad A Tarhini,John M Kirkwood
Ahmad A Tarhini
Pfizer Inc is developing tremelimumab, a fully human monoclonal IgG2 antibody against cytotoxic T-lymphocyte-associated antigen, for the potential intravenous treatment of cancer. Phase III clinical trials to confirm the role of tremelimuma...
Roy A Hall,Alexander A Khromykh
Roy A Hall
Acambis (formerly Peptide Therapeutics) is developing ChimeriVax-West Nile, a recombinant live-attenuated vaccine which incorporates their ChimeriVax platform technology, for the potential prevention of West Nile virus infection [373463], [...
GV-1001, an injectable telomerase peptide vaccine for the treatment of solid cancers [0.03%]
GV-1001：治疗实体瘤的可注射端粒酶肽疫苗
Pilar Nava-Parada,Leisha A Emens
Pilar Nava-Parada
GemVax AS, a subsidiary of Pharmexa A/S, is developing GV-1001, an injectable formulation of a promiscuous MHC class II peptide derived from the telomerase reverse transcriptase catalytic subunit (hTERT), for the potential treatment of soli...