M Sohail,E M Southern
M Sohail
Despite the simplicity of the concept, almost every step in an antisense experiment poses difficulties. Finding a site that is accessible to intermolecular hybridization with complementary nucleic acids is a major problem and determines the...
J K Marquis,J M Grindel
J K Marquis
In this brief review, guidance is provided for the safety evaluation of phosphorothioate oligonucleotides. This novel class of compounds has proved to be challenging for the preclinical development scientist, as systemic exposure can evoke ...
B H Dvorchik
B H Dvorchik
Antisense oligonucleotides hold great promise as novel therapeutic agents designed to specifically and selectively inhibit the production of various disease-related gene products. For efficacy to occur, the therapeutic entity must reach the...
R V Giles
R V Giles
The ability to selectively inhibit gene expression with antisense oligonucleotides could have profound effects upon future biological research, including functional genomics, and the ways in which many diseases are treated. This review desc...
L M Cowsert
L M Cowsert