Madhumita Chatterjee,Michael A Tainsky
Madhumita Chatterjee
In the process of identification of tumor-associated antigens that elicit immunological responses in cancer patients, evidence for the existence of non-traditional immunogens with little sequence homologies to normal open reading frames has...
Manon M J Cox
Manon M J Cox
The baculovirus insect cell production technology allows for rapid vaccine production and is particularly suitable for influenza vaccines where annual adjustment of the composition is required. Recombinant hemagglutinin produced using this ...
Alexander Bukreyev,Peter L Collins
Alexander Bukreyev
Emerging and re-emerging infectious diseases pose a threat to individuals worldwide and necessitate the development of new vaccines and vaccine platforms. Newcastle disease virus (NDV) is an enveloped cytoplasmic RNA virus of avian origin t...
E Antonio Chiocca
E Antonio Chiocca
Clinical trials of oncolytic viruses (OVs) for cancers have revealed that these agents are well tolerated. However, clear-cut evidence of efficacy has been elusive. Although investigators are attempting to generate more efficacious OVs, a f...
Innate immunity, tumor microenvironment and oncolytic virus therapy: friends or foes? [0.03%]
先天免疫、肿瘤微环境与溶瘤病毒治疗：盟友还是对手？
Marianne M Stanford,Caroline J Breitbach,John C Bell et al.
Marianne M Stanford et al.
The field of oncolytic virus (OV) therapy is an innovative and evolving science, taking advantage of the ability of select viruses to preferentially infect and kill human tumor cells. However, the contribution of the tumor microenvironment,...
Tanya Parkinson
Tanya Parkinson
Since the discovery of human TLRs, manipulating the activity of these receptors to modulate immune responses for therapeutic purposes has initiated intense activity in the pharmaceutical industry. The focus of these activities has been larg...
Clinical application of CpG-, non-CpG-, and antisense oligodeoxynucleotides as immunomodulators [0.03%]
CpG、非CpG和反义寡核苷酸的免疫调节作用及其临床应用研究
Annette Dorn,Stefan Kippenberger
Annette Dorn
Cytosine-phosphate-guanosine (CpG) motifs, found mainly in bacterial DNA, have immunostimulatory effects in humans and have offered new perspectives in the treatment of clinical conditions, including viral and bacterial infections, vaccinat...
Michael Whelan,Michael A Morse
Michael Whelan
MM-093, a recombinant human alpha-fetoprotein for the potential treatment of rheumatoid arthritis and other autoimmune diseases [0.03%]
一种重组人胎盘蛋白 1，用于治疗类风湿性关节炎和其他自身免疫疾病的潜在药物 MM-093
Elena Dudich
Elena Dudich
Merrimack Pharmaceuticals Inc (previously Atlantic Biopharmaceuticals) is developing MM-093 (formerly ABI-001), an injectable formulation of a recombinant human alpha-fetoprotein, for the potential treatment of myasthenia gravis, multiple s...
Ranibizumab, a mAb against VEGF-A for the potential treatment of age-related macular degeneration and other ocular complications [0.03%]
抗VEGF-A单抗兰尼单抗治疗年龄相关性黄斑变性和其他眼病的潜力研究
Laura E Lantry
Laura E Lantry
Genentech Inc and Novartis Ophthalmics AG have developed and launched the humanized anti-VEGF antibody fragment ranibizumab, a 48-kDa humanized antibody fragment that inhibits all forms of biologically active VEGF-A, for the treatment of ag...