Emerging role of microRNAs in disease pathogenesis and strategies for therapeutic modulation [0.03%]
微小核糖核酸在疾病发生发展中的作用及治疗策略研究进展
Joerg Mattes,Adam Collison,Paul S Foster
Joerg Mattes
Micro (mi)RNAs are small, regulatory RNA molecules that are integral components of the genetic program in the majority of cells. They are thought to regulate up to one third of all human genes and have been linked to critical processes in d...
Gert-Jan van Ommen,Judith van Deutekom,Annemieke Aartsma-Rus
Gert-Jan van Ommen
Antisense-mediated exon skipping is an approach that uses antisense oligonucleotides (AONs) to modulate splicing by hiding specific sites essential for exon inclusion from the splicing machinery. AONs that block aberrant splice sites can re...
Multifunctional peptide-based nanosystems for improving delivery and molecular imaging [0.03%]
多功能肽基纳米系统用于改善药物递送和分子影像功能
Dwaine F Emerich,Christopher G Thanos
Dwaine F Emerich
Nanotechnology is a multidisciplinary scientific field impacting on various facets of preclinical and clinical research. One of the areas most affected is the development of medical treatments, that is, nanomedicine. In particular, drug del...
EGFR-targeted therapy in colorectal cancer: does immunohistochemistry deserve a role in predicting the response to cetuximab? [0.03%]
表皮生长因子受体靶向治疗结直肠癌：免疫组织化学在预测西妥昔单抗疗效中的作用不容忽视？
Anna Maria Valentini,Michele Pirrelli,Maria Lucia Caruso
Anna Maria Valentini
The EGF receptor (EGFR) has emerged as a rational target for anticancer therapy for the treatment of colorectal cancer (CRC). Positive immunohistochemistry (IHC) staining for EGFR is used as a criterion for patient selection; however, doubt...
Membrane proteins as diagnostic biomarkers and targets for new therapies [0.03%]
膜蛋白作为诊断生物标志物和新疗法靶点的功能基因组学研究
Djuro Josic,James G Clifton,Spomenka Kovac et al.
Djuro Josic et al.
Membrane proteins, especially plasma membrane proteins, form one of the most interesting classes of proteins among disease biomarker candidates. Because of their localization on the surface of cells and organelles, membrane proteins also re...
Identifying autoantigens as theranostic targets: antigen arrays and immunoproteomics approaches [0.03%]
鉴定自身抗原作为诊疗目标：抗原阵列和免疫蛋白质组学方法
Oliver W Tassinari,Robert J Caiazzo Jr,Joshua R Ehrlich et al.
Oliver W Tassinari et al.
The development of theranostics holds great potential for the advancement of personalized medical treatments for human diseases. The theranostic approach combines diagnostic testing with predicted treatment outcomes in order to specifically...
A fight at the opera [0.03%]
歌剧中的搏斗
John Goodchild
John Goodchild
Myodys, a full-length dystrophin plasmid vector for Duchenne and Becker muscular dystrophy gene therapy [0.03%]
用于杜氏肌营养不良症和贝克尔肌营养不良症基因治疗的全长dystrophin质粒载体Myodys
Dongsheng Duan
Dongsheng Duan
Transgene SA is developing Myodys, a non-viral plasmid gene therapy for the potential treatment of Duchenne muscular dystrophy and Becker muscular dystrophy. Phase I clinical trials have been completed, and a phase II clinical trial is plan...
Victor C Huber,Jonathan A McCullers
Victor C Huber
Protein Sciences Corp and UMN Pharma Inc are developing FluBlok, an injectable trivalent influenza vaccine formulation composed of recombinant influenza hemagglutinin (HA) proteins that match the HA from the three influenza isolates that cu...
Heddy Zola,Alice Beare
Heddy Zola
GPC Biotech AG is developing 1D09C3, an anti-MHC class II (HLA-DR) fully human IgG4 antibody isolated by MorphoSys AG (from its HuCAL library of human antibodies), for the potential treatment of hematological malignancies. In December 2006,...