Peter H Roos,Klaus Golka,Jan G Hengstler
Peter H Roos
There is a strong demand for reliable and cost-efficient tumor markers that are suitable for disease screening, prognostics and surveillance. Markers should fulfill certain criteria, such as high sensitivity and specificity and non- or low-...
Interpretation of large-scale quantitative shotgun proteomic profiles for biomarker discovery [0.03%]
大规模定量蛋白质组谱型的解释以发现生物标志物为目标
Ruth Isserlin,Andrew Emili
Ruth Isserlin
Large-scale quantitative shotgun tandem mass spectrometry serves as a flexible proteomic platform for the systematic investigation of molecular processes perturbed by disease and the potential discovery of clinically relevant protein biomar...
Francesca Storici
Francesca Storici
Oligonucleotides represent the most versatile and high-throughput tool for introducing specific modifications in the genome of living cells. These short nucleic acid molecules can be designed and synthesized in large amounts, dispensing wit...
Genotoxicity in gene therapy: an account of vector integration and designer nucleases [0.03%]
基因治疗中的致突变性：载体整合与定制核酸酶的作用报告
Jens Bohne,Toni Cathomen
Jens Bohne
Genotoxicity is a collective term that includes any process which affects the integrity of genomic DNA. With regard to gene therapy, the insertion of genetic elements and the expression of DNA-modifying proteins are the main mediators of ge...
Controlled genetic modification of stem cells for developing drug discovery tools and novel therapeutic applications [0.03%]
可控的遗传学手段改造干细胞以开发新药和新型治疗应用研究
Xianmin Zeng,Mahendra S Rao
Xianmin Zeng
Unlike most adult stem cell populations, embryonic stem cells (ESCs) can replicate indefinitely in culture while preserving genetic, epigenetic, mitochondrial and functional profiles. In addition, ESCs and some adult stem cell populations a...
James J Crowley,Patrick F Sullivan,Howard L McLeod
James J Crowley
Sitimagene ceradenovec, a gene therapeutic for the treatment of glioma [0.03%]
西替迈单抗塞拉朵韦克（一种用于治疗胶质瘤的基因疗法）
Nejat Düzgünes
Nejat Düzgünes
Ark Therapeutics Group plc is developing sitimagene ceradenovec, a herpes simplex virus thymidine kinase/ganciclovir gene therapy utilizing an adenoviral vector, for the potential treatment of glioma. Sitimagene ceradenovec is currently und...
VB4-845, a conjugated recombinant antibody and immunotoxin for head and neck cancer and bladder cancer [0.03%]
VB4-845：用于头颈癌和膀胱癌的结合型重组抗体及免疫毒素
Kristen Biggers,Noah Scheinfeld
Kristen Biggers
Viventia Biotech Inc, under license from the University of Zurich, is developing VB4-845, comprising a Pseudomonas exotoxin fused to an anti-epithelial cell adhesion molecule single-chain antibody fragment, for the potential treatment of he...
Sugar boost: when ribose modifications improve oligonucleotide performance [0.03%]
糖基强化作用：核苷酸的核糖修饰改善其性能
Marcella Faria,Henning Ulrich
Marcella Faria
Since the first antisense oligonucleotides were described, synthetic oligonucleotides have been used to modulate gene expression for numerous research and therapeutic purposes over the last 30 years. In order to improve the performance of o...
Thu Nguyen,Ellen M Menocal,Jens Harborth et al.
Thu Nguyen et al.
RNA interference (RNAi) has rapidly advanced from a laboratory observation into a major area of research within biology and medicine. RNAi is triggered by short interfering RNAs (siRNAs) of between 19 and 21 nucleotides in length, which ind...