Venugopal Nair
Venugopal Nair
Gene therapy using genome-integrating vectors carrying corrective genes offers great potential for the treatment of diseases with an association to genetic defects. Retroviral vectors are still by far the most efficient tools for gene thera...
Clinical trials in gene therapy: ethics of informed consent and the future of experimental medicine [0.03%]
基因治疗临床试验的知情同意伦理及实验医学的未来
Pedro R Lowenstein
Pedro R Lowenstein
Taff Jones
Taff Jones
Bavarian Nordic is developing IMVAMUNE, which is based on a live attenuated modified vaccinia Ankara virus, for the potential prevention of smallpox infection, particularly in those patients contraindicated to traditional smallpox vaccines,...
Gabor Hutas
Gabor Hutas
Centocor Inc and licensees Schering-Plough Corp, Mitsubishi Tanabe Pharma Corp and Janssen Pharmaceutical KK are developing golimumab, a fully human mAb antibody against TNFalpha, for the potential treatment of rheumatoid arthritis (RA), ps...
Steve H Thorne
Steve H Thorne
The field of oncolytic viral therapy has undergone a major shift in focus in the last few years. Less research has been directed at making incremental improvements in original vectors based mainly on strains of adenovirus and HSV; instead a...
Stephen J Russell,Kah Whye Peng
Stephen J Russell
Oncolytic viruses are emerging as promising anticancer agents, but efficient delivery and dispersal at sites of tumor growth remain a significant challenge. Viruses can be efficiently neutralized by antiviral antibodies in the blood stream ...
Shantanu Kumar,Lu Gao,Brian Yeagy et al.
Shantanu Kumar et al.
Oncolytic viruses possess an inherent trophism for tumor cells or have been engineered in a variety of ways to selectively replicate in and destroy cancer cells. Because of the unique mode of tumor destruction, oncolytic virotherapy has the...
Kevin J Harrington,Alan Melcher,Georges Vassaux et al.
Kevin J Harrington et al.
A number of oncolytic viruses (OVs) have undergone extensive preclinical and preliminary clinical evaluation. In addition to their intrinsic antitumor activities, OVs have the potential to enhance the radiation response in a range of tumor ...
Overcoming the extracellular matrix barrier to improve intratumoral spread and therapeutic potential of oncolytic virotherapy [0.03%]
Chae-Ok Yun
Chae-Ok Yun
Genetically attenuated viruses are under development as selectively replicating antitumoral agents. However, the inability of adenoviral vectors to disseminate throughout a solid tumor mass remains a major obstacle in realizing the full pot...
Exploiting diversity: genetic approaches to creating highly potent and efficacious oncolytic viruses [0.03%]
Maxine Bauzon,Terry W Hermiston
Maxine Bauzon
Oncolytic viruses possess several key attributes that make them a highly attractive treatment for cancer. They exhibit clinically validated synergy with chemotherapy and an ability to selectively destroy tumor cells to the exclusion of norm...