Yoshinobu Takakura,Seiji Takemoto,Makiya Nishikawa
Yoshinobu Takakura
Hsp-based tumor vaccines, autologous tumor-derived Hsp-peptide complexes, have been applied to cancer immunotherapy for the treatment of cancer patients with a variety of advanced malignancies. Data from clinical trials, including those fro...
Current approaches in the transcriptional-guided gene therapy of human hepatocellular carcinoma [0.03%]
转录指导的肝细胞癌基因治疗的当前方法
Kam M Hui
Kam M Hui
Hepatocellular carcinoma (HCC), the predominant histological subtype of primary human liver cancer, is one of the most prevalent cancer types worldwide, accounting for an estimated 500,000 deaths annually. The clinical management of HCC is ...
Tessa J M Wijnhoven,Joost F M Lensen,Angelique L Rops et al.
Tessa J M Wijnhoven et al.
Heparan sulfate (HS) is a member of the family of glycosaminoglycans (GAGs) that is generally bound to a core protein to form a proteoglycan (PG). HSPGs may be cell-membrane associated (glypicans and syndecans) or located within the extrace...
Nancy C Connolly,Bonnie A Colleton,Charles R Rinaldo
Nancy C Connolly
The orchestration of a coordinated immune response by dendritic cells (DCs) make them an attractive target for pathogens to exploit to evade host immunity, as well as for use in therapeutic strategies to overcome this exploitation. Because ...
Achim Aigner
Achim Aigner
Since its discovery in the late 1990s, RNA interference (RNAi) has gained much attention as a powerful strategy for silencing activity. Instrumental for this naturally occurring targeting mechanism is the intracellular presence of a target ...
Arne Skerra
Arne Skerra
Members of the human lipocalin protein family exhibit four structurally hypervariable loops that form a ligand pocket, similar to the six complementarity-determining regions of antibodies. Using targeted random mutagenesis and selection, no...
Rob C Roovers,Guus A M S van Dongen,Paul M P van Bergen en Henegouwen
Rob C Roovers
Over the years, many antibodies have been successfully generated to treat patients with life-threatening diseases, most notably cancer. While the first generation of antibodies, originating from mice, caused severe side effects and were rel...
Dafne Müller,Roland E Kontermann
Dafne Müller
Bispecific antibodies recognizing two different antigens present on different cells have been developed for cellular cancer therapy in which cytotoxic effector cells are recruited to tumor cells. Initial studies with bispecific antibodies h...
Terry Hermiston,David Light,Richard Harkins
Terry Hermiston
Drug evaluation: CP-751871, a human antibody against type I insulin-like growth factor receptor for the potential treatment of cancer [0.03%]
药物评价: 针对I型胰岛素样生长因子受体的人源抗体CP-751871，用于治疗癌症的潜在应用
Deepali Sachdev
Deepali Sachdev
Several phase II trials of CP-751871 are currently underway, including a phase Ib/II [corrected] trial of CP-751871 in combination with paclitaxel and carboplatin in patients with advanced NSCLC, a phase II trial of CP-751871 in combination...