Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy [0.03%]
Rab1a和Rab5a优先结合具有更高的储存曲率弹性能量的二元脂质组成
Marie L Kirsten,Rudi A Baron,Miguel C Seabra et al.
Marie L Kirsten et al.
Rab proteins are a large family of GTP-binding proteins that regulate cellular membrane traffic and organelle identity. Rab proteins cycle between association with membranes and binding to RabGDI. Bound on membranes, each Rab has a very spe...
Exploiting Leishmania tarentolae cell-free extracts for the synthesis of human solute carriers [0.03%]
利用Leishmania tarentolae无细胞体系合成人类溶质载体蛋白质 complexes
Suzan Ruehrer,Hartmut Michel
Suzan Ruehrer
Cell-free protein production offers a versatile alternative to complement in vivo expression systems. However, usage of prokaryotic cell-free systems often leads to non-functional proteins. We modified a previously designed cell-free system...
Hydrophobic segment of dengue virus C protein. Interaction with model membranes [0.03%]
登革病毒C蛋白疏水区段及其与模型膜的相互作用
Henrique Nemésio,M Francisca Palomares-Jerez,José Villalaín
Henrique Nemésio
Dengue virus (DENV) C protein is essential for viral assembly. DENV C protein associates with intracellular membranes through a conserved hydrophobic domain and accumulates around endoplasmic reticulum-derived lipid droplets which could pro...
Erik Michael Danielsen,Gert H Hansen,Karina Rasmussen et al.
Erik Michael Danielsen et al.
Absorption of dietary fat in the small intestine involves epithelial exposure to potentially harmful molecules such as bile salts and free fatty acids. We used organ culture of porcine jejunal explants incubated with a pre-digested mixture ...
The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site [0.03%]
在细胞内结合位点鉴定新型高效AQP9抑制剂
Sören J Wacker,Camilo Aponte-Santamaría,Per Kjellbom et al.
Sören J Wacker et al.
Background: The involvement of aquaporin (AQP) water and small solute channels in the etiology of several diseases, including cancer, neuromyelitis optica and body fluid imbalance disorders, has been suggested previously....
Analysis of the inhibition potential of zosuquidar derivatives on selected bacterial and fungal ABC transporters [0.03%]
佐苏奎达衍生物对所选细菌和真菌ABC转运蛋白抑制潜力的分析
Nacera Infed,Sander H J Smits,Torsten Dittrich et al.
Nacera Infed et al.
The increasing number of multidrug-resistant pathogenic microorganisms is a serious public health issue. Among the multitude of mechanisms that lead to multidrug resistance, the active extrusion of toxic compounds, mediated by MDR efflux pu...
Close allies in membrane protein research: cell-free synthesis and nanotechnology [0.03%]
膜蛋白研究中的亲密盟友：无细胞合成与纳米技术
Nadim Shadiac,Yagnesh Nagarajan,Shane Waters et al.
Nadim Shadiac et al.
Membrane proteins control fundamental processes that are inherent to nearly all forms of life such as transport of molecules, catalysis, signaling, vesicle fusion, sensing of chemical and physical stimuli from the environment, and cell-cell...
Use of molecular modelling to probe the mechanism of the nucleoside transporter NupG [0.03%]
利用分子建模技术探讨核苷转运蛋白NupG的作用机制
Hamidreza Vaziri,Stephen A Baldwin,Jocelyn M Baldwin et al.
Hamidreza Vaziri et al.
Nucleosides play key roles in biology as precursors for salvage pathways of nucleotide synthesis. Prokaryotes import nucleosides across the cytoplasmic membrane by proton- or sodium-driven transporters belonging to the Concentrative Nucleos...
Functional reconstitution and osmoregulatory properties of the ProU ABC transporter from Escherichia coli [0.03%]
大肠杆菌普鲁ABC转运蛋白的功能重组及渗透调节性质
Nadia Gul,Bert Poolman
Nadia Gul
The ATP-binding cassette (ABC) transporter ProU from Escherichia coli translocates a wide range of compatible solutes and contributes to the regulation of cell volume, which is particularly important when the osmolality of the environment f...