Location and membrane sources for autophagosome formation - from ER-mitochondria contact sites to Golgi-endosome-derived carriers [0.03%]
自噬体形成的定位及膜来源-从内质网-线粒体接触点到高尔基复合体-溶酶体衍生载体
Shu Ning Chan,Bor Luen Tang
Shu Ning Chan
Recent advances have revealed much about the signaling events and molecular components associated with autophagy. Although it is clear that there are multiple points of intersection and connection between autophagy and known vesicular membr...
Gary Rudnick
Gary Rudnick
Abstract The availability of high-resolution atomic structures for transport proteins provides unprecedented opportunities for understanding their mechanism of action. The details of conformational change can be deduced from these structure...
Samuel Furse,J Antoinette Killian
Samuel Furse
Evidence for sodium metasilicate receptors on the human osteoblast cell surface; spatial localization and binding properties [0.03%]
关于人骨细胞膜上硅酸钠受体的证据；空间定位和结合性能
Kelly-Ann Vere,Joanna L Richens,Jordan S Lane et al.
Kelly-Ann Vere et al.
We report details of the interaction of sodium metasilicate with osteoblast cellular membranes using Fluoresceinphosphatidylethanolamine (FPE) as a fluorescent indicator of membrane interactions. Fluorescence imaging studies of the FPE-base...
Miribane Dërmaku-Sopjani,Selim Kolgeci,Sokol Abazi et al.
Miribane Dërmaku-Sopjani et al.
The Klotho gene was identified as an 'aging suppressor' in mice. Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early death. Both the membrane and secreted forms of Klotho have biological ...
Yan Wang,Sang Ho Park,Ye Tian et al.
Yan Wang et al.
Abstract The role of histidine in channel-forming transmembrane (TM) helices was investigated by comparing the TM helices from Virus protein 'u' (Vpu) and the M2 proton channel. Both proteins are members of the viroporin family of small mem...
Yi Shan Lim,Bor Luen Tang
Yi Shan Lim
The primary cilium that protrudes from the plasma membrane of many eukaryotic cell types is very much a cellular organelle in its own right. Its unique membrane and luminal composition is effectively compartmentalized by diffusion barrier a...
Efficiency of the monofunctionalized C60 fullerenes as membrane targeting agents studied by all-atom molecular dynamics simulations [0.03%]
基于全原子分子动力学模拟研究C60膜靶向试剂的单官能化效率
Semen O Yesylevskyy,Sebastian Kraszewski,Fabien Picaud et al.
Semen O Yesylevskyy et al.
Transmembrane translocation of C60 fullerenes functionalized by the single amino-derivative in neutral and charged forms was studies by extensive all-atom molecular dynamics simulations. It is shown that these complexes exhibit very strong ...
Expression, characterization and ligand specificity of lipocalin-1 interacting membrane receptor (LIMR) [0.03%]
脂质运载蛋白-1相互作用膜受体(LIMR)的表达、鉴定及其配体特异性
Renske W Hesselink,John B C Findlay
Renske W Hesselink
Human lipocalin-1 interacting membrane receptor (LIMR) was the first lipocalin receptor to be identified, as a specific receptor for lipocalin-1 (Lcn1). Subsequently LIMR has been reported to interact with other ligands as well, notably wit...
Lysophosphatidylcholine-induced cytotoxicity in osteoblast-like MG-63 cells: involvement of transient receptor potential vanilloid 2 (TRPV2) channels [0.03%]
溶血磷脂酰胆碱诱导的成骨细胞样MG-63细胞毒性：瞬时受体电位香草酸2通道的参与作用
Abdallah Fallah,Rachel Pierre,Elie Abed et al.
Abdallah Fallah et al.
Epidemiological studies indicate that patients suffering from atherosclerosis are predisposed to develop osteoporosis. Accordingly, atherogenic determinants such as oxidized low density lipoprotein (OxLDL) particles have been shown to alter...