Annarita Ciana,Cesare Achilli,Giampaolo Minetti
Annarita Ciana
The cell type of election for the study of cell membranes, the mammalian non-nucleated erythrocyte, has been scarcely considered in the research of membrane rafts of the plasma membrane. However, detergent-resistant-membranes (DRM) were act...
Scott A Fraser,Matthew Davies,Marina Katerelos et al.
Scott A Fraser et al.
The co-transporter activity of Na(+)-K(+)-2Cl(-) 1 (NKCC1) is dependent on phosphorylation. In this study we show the energy-sensing kinase AMPK inhibits NKCC1 activity. Three separate AMPK activators (AICAR, Phenformin and A-769662) inhibi...
Study of the influence of ascorbyl palmitate and amiodarone in the stability of unilamellar liposomes [0.03%]
抗坏血酸棕榈酸酯和胺碘酮对单层脂质体稳定性的研究
Luciano Benedini,Silvia Antollini,Maria Laura Fanani et al.
Luciano Benedini et al.
Amiodarone (AMI) is a low water-solubility drug, which is very useful in the treatment of severe cardiac disease. Its adverse effects are associated with toxicity in different tissues. Several antioxidants have been shown to reduce, and pre...
Evidence of TGF-β1 mediated epithelial-mesenchymal transition in immortalized benign prostatic hyperplasia cells [0.03%]
TGF-β1诱导的前列腺增生上皮间质转化模型的建立及SB431542部分逆转上述过程
Shuai Hu,Wei Yu,Tian-Jing Lv et al.
Shuai Hu et al.
Expression of epithelial-mesenchymal transition (EMT) markers has been detected clinically in benign prostatic hyperplasia (BPH) tissues. To understand the molecular basis, we investigated the role of stromal microenvironment in the progres...
The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis [0.03%]
逃避免疫识别的肿瘤发生中的终末内体分选复合体的作用
Claudia Mattissek,David Teis
Claudia Mattissek
The endosomal sorting complexes required for transport (ESCRT) are needed for three distinct cellular functions in higher eukaryotes: (i) Multivesicular body formation for the degradation of transmembrane proteins in lysosomes, (ii) midbody...
Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1 [0.03%]
血清和糖皮质激素诱导型激酶SGK1调控跨细胞膜转运的功能研究
Florian Lang,Christos Stournaras,Ioana Alesutan
Florian Lang
The serum- and glucocorticoid-inducible kinase 1 (SGK1) is genomically upregulated by cell stress including energy depletion and hyperosmotic shock as well as a variety of hormones including glucocorticoids, mineralocorticoids and TGFβ. SG...
Paul Linsdell
Paul Linsdell
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), a member of the ATP-binding cassette (ABC) family of membrane transport proteins. CFTR is unique among ABC proteins in that it functio...
Structural impact of cations on lipid bilayer models: nanomechanical properties by AFM-force spectroscopy [0.03%]
阳离子对脂质双层模型结构影响的原子力显微镜力谱研究
Lorena Redondo-Morata,Marina I Giannotti,Fausto Sanz
Lorena Redondo-Morata
Atomic Force Microscopy (AFM) has become an invaluable tool for studying the micro- and nanoworlds. As a stand-alone, high-resolution imaging technique and force transducer, it defies most other surface instrumentation in ease of use, sensi...
Fe- but not Mg-protophorphyrin IX binds to a transmembrane b-type cytochrome [0.03%]
铁但不是镁原卟啉IX与跨膜b型细胞色素结合
Lydia Tome,Cornelia Schaetzel,Carolin Dreher et al.
Lydia Tome et al.
Transmembrane b-type cytochromes, which are crucially involved in electron transfer chains, bind one or more heme (Fe-protoporphyrin IX) molecules non-covalently. Similarly, chlorophylls are typically also non-covalently bound by several me...
Cyclic GMP regulates M₃AChR activity at plasma membranes from airway smooth muscle [0.03%]
环GMP调节气道平滑肌细胞质膜上M3胆碱受体的活性
Marcelo J Alfonzo,Ramona González De Alfonzo,Marcelo A Alfonzo-González et al.
Marcelo J Alfonzo et al.
Muscarinic acetylcholine receptors MAChRs from Bovine Tracheal Smooth Muscle (BTSM) plasma membranes are responsible for the cGMP rise and signal-amplitude peaks associated with smooth muscle contraction present in bronchial asthma. These M...