Mohan C Pereira,Monica Pianella,Da Wei et al.
Mohan C Pereira et al.
Nanomedicine is becoming very popular over conventional methods due to the ability to tune physico-chemical properties of nano vectors, which are used for encapsulation of therapeutic and diagnostic agents. However, the success of nanomedic...
Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: Involvement of transfection procedure [0.03%]
姜黄素通过抑制转染诱导的瞬时受体电位模通道M2激活、钙离子内流和神经母细胞凋亡值升高保护SH-SY5Y细胞氧化应激损伤的作用机制研究
Ahmi Öz,Ömer Çelik
Ahmi Öz
Transient Receptor Potential (TRP) channels are mostly Ca2+ permeable cation channels. Transient Receptor Potential Melastatin-like 2 (TRPM2) is expressed in neurological tissues such as brain, dorsal root ganglia (DRG) neurons, hippocampus...
Secretome derived from breast tumor cell lines alters the morphology of human umbilical vein endothelial cells [0.03%]
乳腺肿瘤细胞系分泌组可改变人脐静脉内皮细胞形态学
Erika Olivia Gómez,Yolanda Irasema Chirino,Norma Laura Delgado-Buenrostro et al.
Erika Olivia Gómez et al.
Metastases, responsible for most of the solid tumor associated deaths, require angiogenesis and changes in endothelial cells. In this work, the effect of the secretomes of three breast tumor cell lines (MCF-7, MDA-MB-231 and ZR-75-30) on hu...
The changing landscape of membrane protein structural biology through developments in electron microscopy [0.03%]
电子显微镜技术的发展对膜蛋白结构生物学的影响
Shaun Rawson,Simon Davies,Jonathan D Lippiat et al.
Shaun Rawson et al.
Membrane proteins are ubiquitous in biology and are key targets for therapeutic development. Despite this, our structural understanding has lagged behind that of their soluble counterparts. This review provides an overview of this important...
Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation [0.03%]
牻牛儿基牻牛儿焦磷酸合酶与细胞存活和增殖的分子机制之间的联系
Sherry S Agabiti,Yilan Liang,Andrew J Wiemer
Sherry S Agabiti
Geranylgeranyl diphosphate is a 20-carbon isoprenoid phospholipid whose lipid moiety can be post-translationally incorporated into proteins to promote membrane association. The process of geranylgeranylation has been implicated in anti-prol...
The influence of NBD fluorescent probe on model membranes containing POPC and DPPC [0.03%]
NBD荧光探针对于POPC和DPPC模型膜的影响
Chi-Jung Weng,Ju-Ping Wu,Ming-Yen Kuo et al.
Chi-Jung Weng et al.
To investigate the effect of fluorescent probe on the properties of membranes, we studied model membranes composed of 1,2- dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1-palmitoyl 2-oleoyl-sn-glycero-3-phosphocholine (POPC) in the pre...
Slippery signaling: Palmitoylation-dependent control of neuronal kinase localization and activity [0.03%]
丝氨酸 palmitoyl转移酶信号通路对神经元激酶定位和活性的调控作用
Audrey Montersino,Gareth M Thomas
Audrey Montersino
Modification of proteins with the lipid palmitate, a process called palmitoylation, is important for the normal function of neuronal cells. However, most attention has focused on how palmitoylation regulates the targeting and trafficking of...
Electrostatic networks control plug stabilization in the PapC usher [0.03%]
静电网络控制PapCusher中的插件稳定化现象
Thieng Pham,Nadine S Henderson,Glenn T Werneburg et al.
Thieng Pham et al.
The PapC usher, a β-barrel pore in the outer membrane of uropathogenic Escherichia coli, is used for assembly of the P pilus, a key virulence factor in bacterial colonization of human kidney cells. Each PapC protein is composed of a 24-str...
The influence of an antitumor lipid - erucylphosphocholine - on artificial lipid raft system modeled as Langmuir monolayer [0.03%]
一种抗肿瘤脂质—月桂季
Anita Wnętrzak,Kazimierz Łątka,Katarzyna Makyła-Juzak et al.
Anita Wnętrzak et al.
Outer layer of cellular membrane contains ordered domains enriched in cholesterol and sphingolipids, called 'lipid rafts', which play various biological roles, i.e., are involved in the induction of cell death by apoptosis. Recent studies h...
Deuterated detergents for structural and functional studies of membrane proteins: Properties, chemical synthesis and applications [0.03%]
用于膜蛋白结构与功能研究的氘代去污剂：特性、化学合成及应用
Kazumi Hiruma-Shimizu,Hiroki Shimizu,Gary S Thompson et al.
Kazumi Hiruma-Shimizu et al.
Detergents are amphiphilic compounds that have crucial roles in the extraction, purification and stabilization of integral membrane proteins and in experimental studies of their structure and function. One technique that is highly dependent...