Wiktor Jurkowski,Samira Yazdi,Arne Elofsson
Wiktor Jurkowski
The galanin receptor family comprises of three members, GalR1, GalR2 and GalR3, all belonging to the G-protein-couple receptor superfamily. All three receptors bind the peptide hormone galanin, but show distinctly different binding properti...
John Mifsud,Stéphanie Ravaud,Eva-Maria Krammer et al.
John Mifsud et al.
The mitochondrial ADP/ATP carrier imports ADP from the cytosol into the mitochondrial matrix for its conversion to ATP by ATP synthase and exports ATP out of the mitochondrion to replenish the eukaryotic cell with chemical energy. Here the ...
Probing the contacts of a low-affinity substrate with a membrane-embedded transport protein using 1H-13C cross-polarisation magic-angle spinning solid-state NMR [0.03%]
利用魔角旋转固态NMR研究膜蛋白与低亲和力底物的相互作用
Simon G Patching,Peter J F Henderson,David J Sharples et al.
Simon G Patching et al.
Solid-state NMR combined with sample deuteration was used to probe the proximity of the low-affinity substrate D-glucose to its binding site within the Escherichia coli sugar transport protein GalP. Samples of E. coli inner membranes with a...
An emerging consensus on aquaporin translocation as a regulatory mechanism [0.03%]
关于水通道蛋白转运作为调节机制的新共识观点
Alex C Conner,Roslyn M Bill,Matthew T Conner
Alex C Conner
Water passes through cell membranes relatively slowly by diffusion. In order to maintain water homeostasis, the rapid and specific regulation of cellular water flow is mediated by the aquaporin (AQP) family of membrane protein water channel...
The substrate specificity of mitochondrial carriers: mutagenesis revisited [0.03%]
线粒体载体的底物特异性：突变功能再研究
Magnus Monné,Ferdinando Palmieri,Edmund R S Kunji
Magnus Monné
Mitochondrial carriers transport inorganic ions, nucleotides, amino acids, keto acids and cofactors across the mitochondrial inner membrane. Structurally they consist of three domains, each containing two transmembrane α-helices linked by ...
Linking epigenetics to lipid metabolism: focus on histone deacetylases [0.03%]
表观遗传学与脂质代谢之间的联系：组蛋白去乙酰化酶的作用
Alessandra Ferrari,Erika Fiorino,Marco Giudici et al.
Alessandra Ferrari et al.
A number of recent studies revealed that epigenetic modifications play a central role in the regulation of lipid and of other metabolic pathways such as cholesterol homeostasis, bile acid synthesis, glucose and energy metabolism. Epigenetic...
Specific aquaporins increase the ammonia tolerance of a Saccharomyces cerevisiae mep1-3 fps1 deletion strain [0.03%]
特定的水通道蛋白能够增加拜尔斯酵母mep1-3 fps1基因敲除菌株的耐氨性
Dawid Krenc,Binghua Wu,Eric Beitz
Dawid Krenc
Abstract Aquaporins (AQPs) are channel proteins which facilitate the bidirectional membrane permeation of small neutral molecules such as water and glycerol. A convenient way to characterize their permeability is by growth of transformed Sa...
A systematic approach to the amplified expression, functional characterization and purification of inositol transporters from Bacillus subtilis [0.03%]
枯草芽孢杆菌肌醇转运蛋白的表达、鉴定及纯化的新方法研究
Kim E Bettaney,Preethi Sukumar,Rohanah Hussain et al.
Kim E Bettaney et al.
Abstract A systematic approach was used for the cloning and amplified expression in Escherichia coli of the genes for each of three inositol transport proteins (IolF, IolT, YfiG) from Bacillus subtilis that are evolutionarily-related to hum...
Overexpression of membrane proteins in mammalian cells for structural studies [0.03%]
用于结构研究的膜蛋白在哺乳动物细胞中的过表达
Juni Andréll,Christopher G Tate
Juni Andréll
The number of structures of integral membrane proteins from higher eukaryotes is steadily increasing due to a number of innovative protein engineering and crystallization strategies devised over the last few years. However, it is sobering t...