Experimental and computational analysis of SERCA inhibition by naphthoquinone derivatives [0.03%]
萘醌衍生物抑制SERCA的实验和计算分析
Sophie Cheng,Sahil Kumar,Sydni Sobota et al.
Sophie Cheng et al.
Naphthoquinones are small aromatic compounds with diverse biological activities and established applications in medicine and industry. Previous studies have identified a limited number of naphthoquinones that inhibit the sarco/endoplasmic r...
Secondary structure engineering of an amphipathic arginine-rich CPP using non-proteinogenic amino acids for enhanced cell-membrane permeability [0.03%]
基于非蛋白氨基酸的细胞穿透肽二级结构工程改造以增强生物膜穿膜能力
Wataru Sato,Yurina Sekine,Takahito Ito et al.
Wataru Sato et al.
Cell-penetrating peptides (CPPs) represent a powerful class of drug delivery systems for transporting impermeable cargo into the intracellular space. While the B-peptide (Sequence: RXRRBRRXRRBRXB; B = β-alanine, X = 1-aminohexanoic acid) h...
Advancements in diverse chemical scaffolds for antimalarial drug discovery: a ten-year hit-to-lead retrospective [0.03%]
抗疟药物发现中的化学骨架多样性进展：为期十年的从苗头化合物到先导物研究回顾性分析
Marcelo Augusto Pereira Januário,Douglas Davison da Silva Oliveira,Flávio Luis Cardoso Silveira et al.
Marcelo Augusto Pereira Januário et al.
Malaria remains one of the most devastating parasitic diseases worldwide, accounting for hundreds of millions of cases and significant mortality annually. Despite the availability of therapeutic interventions, the efficacy of current pharma...
Improvements in potency and selectivity of triazine nitrile inhibitors targeting Toxoplasma gondii cathepsin L for the treatment of latent toxoplasmosis [0.03%]
三嗪腈抑制剂改善了针对弓形虫囊尾蚴猫泡状 протозоа酶的效力和特异性以治疗隐性弓形虫病
Timothy J Borel nd,Jacob R Hitchens,Hargobinder Kaur et al.
Timothy J Borel nd et al.
The protozoan Toxoplasma gondii is one of the most prevalent infectious agents, having infected approximately one third of the global population. It remains a leading cause of deaths due to foodborne illness, can cause serious complications...
A general tyrosinase-responsive prodrug strategy: design and synthesis of melanoma-selective anticancer agents [0.03%]
一种通用的酪氨酸酶响应型前药策略：用于设计和合成选择性黑色素瘤抗癌剂
Boxiang Qiu,Yening Zou,Binjie Li et al.
Boxiang Qiu et al.
Melanoma is highly aggressive with limited therapeutic options for advanced-stage disease, making it the leading cause of skin cancer-related deaths. This study developed a tyrosinase (TYR)-responsive prodrug design strategy by taking TYR-a...
Physicochemical and RNA structural features of selective RNA binding by drug-like small molecules [0.03%]
药物样小分子选择性结合RNA的理化、结构特征分析
Hiroki Yoshida,Ryosuke Nagasawa,Kaoru R Komatsu
Hiroki Yoshida
Binding selectivity is critical for small molecules targeting RNA in the therapeutic field, requiring rational design of selective compounds. However, the key features of selective binding remain incompletely understood due to lack of compr...
Wee1-targeting inhibitors: From virtual screening to lead discovery [0.03%]
从计算机虚拟筛选到先导化合物发现——Wee1靶向抑制剂研究
Jochem Nelen,Bidisha Sarkar,Javier Jiménez-Bernad et al.
Jochem Nelen et al.
Wee1-like protein kinase (Wee1) is a validated target for cancer therapy, though no inhibitors have yet received regulatory approval. To identify new Wee1 inhibitors, we conducted a virtual screening campaign using the Eurofins-Villapharma ...
Design, synthesis and biological evaluation of benzimidazole carbamide derivatives - potential autophagy inducers [0.03%]
苯并咪唑碳酰胺衍生物的设计、合成及生物活性评价——潜在的自噬诱导剂
Maria V Zapevalova,Ekaterina A Guseva,Sofya Y Sokolskaya et al.
Maria V Zapevalova et al.
Herein, we report a convenient synthetic approach and an in vitro evaluation of benzimidazole carbamide derivatives as potential autophagy activators. Two compounds exhibited autophagy-inducing activity at concentrations ≥100 μM. The most...
Synthesis and pharmacological evaluation of benzimidazole amine derivatives as novel allosteric antagonists for β2-adrenergic receptor [0.03%]
一类新型β2-肾上腺素受体变构拮抗剂的苯并咪唑胺类衍生物的设计、合成及药理评价研究
Yu Chen,Kexin Ye,Yujie Zhang et al.
Yu Chen et al.
Based on the previous research addressing the insufficient stability of benzimidazole amide derivatives, in this study we synthesized two novel classes of the allosteric antagonists for the β2-adrenergic receptor (β2AR) through structural...
Development of highly potent EP2 antagonists as novel anti-inflammatory neuroprotectants [0.03%]
高效EP2拮抗剂的开发作为新型抗炎神经保护剂
Chenyao Jiang,Eun Bee Cho,Zhen Jin et al.
Chenyao Jiang et al.
Prostaglandin E2 (PGE2) is a key bioactive lipid mediator that drives neuroinflammation and exacerbates brain tissue damage largely via acting on its receptor EP2 subtype. As such, EP2 has been emerging as an alternative target to cyclooxyg...