Phenotyping psychosis: room for neurocomputational and content-dependent cognitive endophenotypes? [0.03%]
精神病的表型：基于神经计算和内容依赖的认知内表型有什么作用？
Eric Y H Chen,Gloria H Y Wong,Christy L M Hui et al.
Eric Y H Chen et al.
Introduction: The endophenotype research strategy aims at reducing complex clinical phenomena to reveal a more tractable mapping to underlying genes. Cognitive dysfunctions have been widely pursued as target endophenotype...
Robert M Bilder,Fred W Sabb,D Stott Parker et al.
Robert M Bilder et al.
Now that genome-wide association studies (GWAS) are dominating the landscape of genetic research on neuropsychiatric syndromes, investigators are being faced with complexity on an unprecedented scale. It is now clear that phenomics, the sys...
Genome-wide strategies for discovering genetic influences on cognition and cognitive disorders: methodological considerations [0.03%]
认知与认知障碍的全基因组策略：方法学问题考虑
Steven G Potkin,Jessica A Turner,Guia Guffanti et al.
Steven G Potkin et al.
Introduction: Genes play a well-documented role in determining normal cognitive function. This paper focuses on reviewing strategies for the identification of common genetic variation in genes that modulate normal and abn...
Abraham Reichenberg,Jonathan Mill,James H MacCabe
Abraham Reichenberg
Introduction: There is growing interest in the role of single genes in cognitive functions. Association studies are the most commonly applied method in this field. This method assumes that the genetic information affectin...
Jeremy Koppel,Terry Goldberg
Jeremy Koppel
Introduction: Studies suggest that there is a considerable genetic contribution to individual episodic memory performance. Identifying genes which impact recollection may further elucidate an emerging biology and pave the...
Genetic variation influences on the early development of reactive emotions and their regulation by attention [0.03%]
遗传变异对反应性情绪早期发展的影响及其注意力调节作用
Brad E Sheese,Pascale Voelker,Michael I Posner et al.
Brad E Sheese et al.
Introduction: Individual differences in temperament and attention provide an important link between normal and pathological development. Previous studies suggest that during infancy, orienting of attention is associated w...
Learning abilities and disabilities: generalist genes in early adolescence [0.03%]
学习障碍与天赋：青少年早期的泛基因作用机制研究
Oliver S P Davis,Claire M A Haworth,Robert Plomin
Oliver S P Davis
Introduction: The new view of cognitive neuropsychology that considers not just case studies of rare severe disorders but also common disorders, as well as normal variation and quantitative traits, is more amenable to rec...
The role of general intelligence as an intermediate phenotype for neuropsychiatric disorders [0.03%]
作为神经精神疾病中间表型的通用智能的作用
Katherine E Burdick,Nisali Gunawardane,Kristen Woodberry et al.
Katherine E Burdick et al.
Introduction: Neurocognitive impairment is common to several neuropsychiatric disorders. The growing use of cognitive impairment as an intermediate phenotype, or "endophenotype", in psychiatry raises the issue of whether ...
Prefrontal cognitive systems in schizophrenia: towards human genetic brain mechanisms [0.03%]
精神分裂症的前额认知系统：迈向人类遗传的大脑机制
Hao-Yang Tan,Joseph H Callicott,Daniel R Weinberger
Hao-Yang Tan
Schizophrenia has complex genetic heritability. It is also genetically heterogeneous. To the extent that genes are associated with symptom constellations in schizophrenia, they do so by affecting the development and function of neural syste...
Brita Elvevåg,Daniel R Weinberger
Brita Elvevåg
Numerous genes modulate dopamine and consequently prefrontal cortical function. Some of these genes - notably catechol-O-methyltransferase - have been shown to impact a variety of core cognitive processes that are dependent upon the prefron...