T T Schug,R Abagyan,B Blumberg et al.
T T Schug et al.
A central goal of green chemistry is to avoid hazard in the design of new chemicals. This objective is best achieved when information about a chemical's potential hazardous effects is obtained as early in the design process as feasible. End...
Installation of protected ammonia equivalents onto aromatic & heteroaromatic rings in water enabled by micellar catalysis [0.03%]
由胶束催化在水相中实现芳香环和杂芳香环上保护胺的安装反应
Nicholas A Isley,Sebastian Dobarco,Bruce H Lipshutz
Nicholas A Isley
A single set of conditions consisting of a palladium catalyst, a commercially available ligand, and a base, allow for several types of C-N bond constructions to be conducted in water with the aid of a commercially available "designer" surfa...
James C Fennewald,Bruce H Lipshutz
James C Fennewald
Using a reaction medium containing nanoparticles consisting of commercially available TPGS-750-M in water, a combination of Langlois' reagent and t-BuOOH can be used to effect trifluoromethylation of several heterocyclic arrays, including h...
Zebrafish Assays as Developmental Toxicity Indicators in The Design of TAML Oxidation Catalysts [0.03%]
斑马鱼试验在TAML氧化催化剂设计中的发育毒性指示作用
Lisa Truong,Matthew A Denardo,Soumen Kundu et al.
Lisa Truong et al.
TAML activators promise a novel water treatment approach by efficiently catalysing peroxide-based degradation of chemicals of high concern at environmental concentrations. Green design ethics demands an exploration of TAML toxicity. Exposur...
Integrating zebrafish toxicology and nanoscience for safer product development [0.03%]
整合斑马鱼毒理学和纳米科学以促进更安全的产品研发
Ki-Tae Kim,Robert L Tanguay
Ki-Tae Kim
The design, manufacture and application of safer products and manufacturing processes have been important goals over the last decade and will advance in the future under the umbrella of "Green Chemistry". In this review, we focus on the bur...
Remarkable facilitation of hetero-cycloisomerizations with water and other polar protic solvents: metal-free synthesis of indolizines [0.03%]
用水和其他极性含氢溶剂显著促进的杂环异构化反应：金属催化吲哚嗪合成的新方法
Alison R Hardin Narayan,Richmond Sarpong
Alison R Hardin Narayan
Hetero-cycloisomerization reactions of propargylic alcohol derivatives leading to indolizines have been demonstrated to proceed in the presence of water alone. This stands as a significant advance over the previous methods using Pt, Cu or A...
Development of Safe and Scalable Continuous-Flow Methods for Palladium-Catalyzed Aerobic Oxidation Reactions [0.03%]
钯催化下安全且可拓展的连续流动体系中氧氧化反应的研究和发展
Xuan Ye,Martin D Johnson,Tianning Diao et al.
Xuan Ye et al.
The synthetic scope and utility of Pd-catalyzed aerobic oxidation reactions has advanced significantly over the past decade, and these reactions have potential to address important green-chemistry challenges in the pharmaceutical industry. ...
Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols [0.03%]
离子液体对环氧脂烃化酶催化合成手性1,2-二醇反应的影响
Cinzia Chiappe,Elsa Leandri,Bruce D Hammock et al.
Cinzia Chiappe et al.
Ionic liquids (ILs) offer new possibilities for epoxide hydrolase (EH) catalyzed resolution of epoxides and for synthesis of chiral 1,2-diols. Soluble EHs from cress and mouse (csEH and msEH) and microsomal EH from rat (rmEH) were tested in...