Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol [0.03%]
加压二氧化碳作为羧化剂用于邻氨基酚的生物催化羧基化反应
Katharina Plasch,Gerhard Hofer,Walter Keller et al.
Katharina Plasch et al.
The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on a large scale. As a proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in...
Metal-free Regioselective Hydrochlorination of Unactivated Alkenes via a Combined Acid Catalytic System [0.03%]
一种结合酸催化体系对非活化烯烃进行金属自由区域选择性氯化的研究
Shengzong Liang,Gerald B Hammond,Bo Xu
Shengzong Liang
A combined acid HCl/DMPU-acetic acid catalytic system was used in the hydrochlorination of a wide range of unactivated alkenes. This hydrochlorination strategy is remarkably greener than previous reported methods in terms of high atom effic...
Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds [0.03%]
胺脱氢酶：羰基化合物还原胺化的高效生物催化剂
Tanja Knaus,Wesley Böhmer,Francesco G Mutti
Tanja Knaus
Amines constitute the major targets for the production of a plethora of chemical compounds that have applications in the pharmaceutical, agrochemical and bulk chemical industries. However, the asymmetric synthesis of α-chiral amines with e...
QSAR models of human data can enrich or replace LLNA testing for human skin sensitization [0.03%]
基于人类数据的QSAR模型可以丰富或替代LLNA试验用于人体皮肤致敏性测试
Vinicius M Alves,Stephen J Capuzzi,Eugene Muratov et al.
Vinicius M Alves et al.
Skin sensitization is a major environmental and occupational health hazard. Although many chemicals have been evaluated in humans, there have been no efforts to model these data to date. We have compiled, curated, analyzed, and compared the...
Vinicius Alves,Eugene Muratov,Stephen Capuzzi et al.
Vinicius Alves et al.
Structural alerts are widely accepted in chemical toxicology and regulatory decision support as a simple and transparent means to flag potential chemical hazards or group compounds into categories for read-across. However, there has been a ...
Pamela D Noyes,Gloria R Garcia,Robert L Tanguay
Pamela D Noyes
Heightened public awareness about the many thousands of chemicals in use and present as persistent contaminants in the environment has increased the demand for safer chemicals and more rigorous toxicity testing. There is a growing recogniti...
Improved methods for evaluating the environmental impact of nanoparticle synthesis† [0.03%]
改进纳米粒子合成环境影响的评估方法
Bradley T Reid,Scott M Reed
Bradley T Reid
With the market for products containing nanoparticles growing, improvements in the efficiency of nanoparticle synthesis are poised to have significant positive economic and environmental impacts. While many metrics have been designed for me...
Suitability of bio-based ionic liquids for the extraction and purification of IgG antibodies [0.03%]
生物基离子液体提取和纯化IgG抗体的适用性
Dibyendu Mondal,Mukesh Sharma,Maria V Quental et al.
Dibyendu Mondal et al.
In the past decade, remarkable advances in the production and use of antibodies as therapeutic drugs and in research/diagnostic fields have led to their recognition as value-added proteins. These biopharmaceuticals have become increasingly ...
A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives [0.03%]
基于化学生物相似性的复杂物质分组作为评估化学品替代品的原型方法
Fabian A Grimm,Yasuhiro Iwata,Oksana Sirenko et al.
Fabian A Grimm et al.
Comparative assessment of potential human health impacts is a critical step in evaluating both chemical alternatives and existing products on the market. Most alternatives assessments are conducted on a chemical-by-chemical basis and it is ...
Ajay L Chandgude,Alexander Dömling
Ajay L Chandgude
A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three component reaction (PT-3CR) has been developed. It comprises reaction of an aldehyde/ketone, a isocyanide and a TMS-azide in me...