Computational chemistry, data mining, high-throughput synthesis and screening--informatics and integration in drug discovery [0.03%]
计算化学、数据挖掘、高通量合成与筛选——药物发现中的信息学及集成研究
C J Manly
C J Manly
Drug discovery today includes considerable focus of laboratory automation and other resources on both combinatorial chemistry and high-throughput screening, and computational chemistry has been a part of pharmaceutical research for many yea...
J A Potter
J A Potter
Significant advances within the field of laboratory automation and instrumentation have greatly benefited the pharmaceutical industry in its quest to discover, develop and monitor the quality of its products. Necessitated by the need for ef...
My continuing adventure with 21 CFR Part 11--the evolution of Zymark's compliance [0.03%]
我和21 CFR Part 11的继续历险——Zymark公司符合规范的演变过程
S M Dobro
S M Dobro
A renewed focus has been given to the 3-year-old regulation 21 CFR Part 11, Electronic Records and Electronic Signatures. This paper gives a chronology of the process of an equipment vendor, Zymark Corporation, validating laboratory automat...
Optimizing production of serially diluted compounds and distribution to multiple targets [0.03%]
优化顺序稀释化合物的生成与多个目标的分配问题
C O Harris,S L Schweiker
C O Harris
The need for a multiple-target compound selectivity programme led to the establishment of a single robotic system that produces a compound's serial dilution and its distribution to multiple replicate assay plates. A Genesis RSP 150 integrat...
Expediting the formulation development process with the aid of automated dissolution in analytical research and development [0.03%]
借助于分析研究与开发中的自动化溶出技术加速制剂开发过程
J P Sadowitz
J P Sadowitz
The development of drugs in the generic pharmaceutical industry is a highly competitive arena of companies vying for few drug products that are coming off patent. Companies that have been successful in this arena are those that have met or ...
Speciation of inorganic selenium and selenoamino acids by an HPLC-UV-HG-AFS system [0.03%]
高效液相紫外氢化物原子荧光联用法同时测定无机硒和硒代氨基酸
I Ipolyi,W Corns,P Stockwell et al.
I Ipolyi et al.
For the on-line speciation of selenocystine (SeCys), selenomethionine (SeMet), selenoethionine (SeEt), selenite (Se(IV)) and selenate (Se(VI)), a high-performance liquid chromatography-UV irradiation-hydride generation-atomic fluorescence s...
R Thiericke
R Thiericke
Secondary metabolites from plants, animals and microorganisms have been proven to be an outstanding source for new and innovative drugs and show a striking structural diversity that supplements chemically synthesized compounds or libraries ...
P Skehan
P Skehan
Numerical taxonomy and pattern recognition analysis offer powerful tools that can greatly reduce the information burden of multiple-assay screening programs. These methods can be used to rationally design prescreens, identify assays that ha...
An industrial engineering approach to laboratory automation for high throughput screening [0.03%]
高通量筛选的实验室自动化工业工程方法学研究
K C Menke
K C Menke
Across the pharmaceutical industry, there are a variety of approaches to laboratory automation for high throughput screening. At Sphinx Pharmaceuticals, the principles of industrial engineering have been applied to systematically identify a...
Case study of the automation options and decisions made in implementing a high-throughput cell based screen using the FLIPR [0.03%]
FLIPR技术进行高通量细胞功能筛选的自动化的方案选择和实现过程分析
D J Hook
D J Hook
This case study examines the automation and process change options available to emerging discovery/development stage pharmaceutical companies when considering implementing sophisticated high-throughput screens. Generally there are both fina...