The rare and the common: scale and the genetic imaginary in Alzheimer's disease drug development [0.03%]
阿尔茨海默病药物研发中的缩放与遗传思维
Richard Milne
Richard Milne
In this paper I examine how the promissory value of genetics is constituted through processes of scale and scaling, focussing on the relationship between "rare" and "common" forms of disease. I highlight the bodies and spaces involved in th...
Biomarkers and brains: situating dementia in the laboratory and in the memory clinic [0.03%]
标志物和大脑：实验室和记忆诊所中的痴呆定位研究
Joanna Latimer,Alexandra Hillman
Joanna Latimer
This paper provides a comparison of how genetic biomarkers are used (or not) in three contexts: clinic-based diagnostic work with people; lab-based research on mice and their marbles; and lab-based research on thrashing nematodes. For all t...
Consumer (dis-)interest in Genetic Ancestry Testing: The roles of race, immigration, and ancestral certainty [0.03%]
消费者对基因祖源检测的（不）感兴趣：种族、移民和祖先确定性的角色
Adam L Horowitz,Aliya Saperstein,Jasmine Little et al.
Adam L Horowitz et al.
Genetic ancestry testing (GAT) is marketed as a way to make up for missing knowledge about one's ancestry. Previous research questions the GAT industry's ability to fulfill this promise in terms of the validity and reliability of test resul...
Contested futures: envisioning "Personalized," "Stratified," and "Precision" medicine [0.03%]
contested futures: envisioning "personalized," "stratified," and "precision" medicine
Sonja Erikainen,Sarah Chan
Sonja Erikainen
In recent years, discourses around "personalized," "stratified," and "precision" medicine have proliferated. These concepts broadly refer to the translational potential carried by new data-intensive biomedical research modes. Each describes...
Knowing something versus feeling different:The effects and non-effects of genetic ancestry on racial identity [0.03%]
知与感：基因族裔对族裔认同的影响与非影响
Janet K Shim,Sonia Rab Alam,Bradley E Aouizerat
Janet K Shim
Since the completion of the Human Genome Project, there have been pitched debates about its implications and the research it enables. One prominent thread of concern focuses on the role of post-genomic science on technically enabling and ge...
Genomic research and the cancer clinic: uncertainty and expectations in professional accounts [0.03%]
基因组研究与肿瘤学临床实践：专业人员眼中的不确定性与期待感
Anne Kerr,Julia Swallow,Choon Key Chekar et al.
Anne Kerr et al.
This paper explores clinicians' and scientists' accounts of genomic research in cancer care and the complexities and challenges involved with delivering this work. Contributing to the sociology of (low) expectations, we draw on sociological...
"I6 passages: on the reproduction of a human embryonic stem cell line from Israel to France" [0.03%]
"从以色列到法国的人类胚胎干细胞系I6的传代"
Noémie Merleau-Ponty,Sigrid Vertommen,Michel Pucéat
Noémie Merleau-Ponty
The first French clinical trial using human embryonic stem cells for regenerative purposes was launched in 2014, using the I6 stem cell line that was imported from Israel. From Israel to France, national reproductive policies and practices ...
Identity, community and care in online accounts of hereditary colorectal cancer syndrome [0.03%]
线上遗传性结直肠癌综合征账户中的身份、社区和关怀
Emily Ross,Tineke Broer,Anne Kerr et al.
Emily Ross et al.
Sociological literature has explored how shifts in the point at which individuals may be designated as diseased impact upon experiences of ill health. Research has shown that experiences of being genetically "at risk" are shaped by and shap...
The UK's 100,000 Genomes Project: manifesting policymakers' expectations [0.03%]
英国的“十万基因组计划”：展现决策者的期望值
Gabrielle Natalie Samuel,Bobbie Farsides
Gabrielle Natalie Samuel
The UK's 100,000 Genomes Project has the aim of sequencing 100,000 genomes from UK National Health Service (NHS) patients while concomitantly transforming clinical care such that whole genome sequencing becomes routine clinical practice in ...
Andrew Bartlett,Jamie Lewis,Matthew L Williams
Andrew Bartlett
Bioinformatics, a specialism propelled into relevance by the Human Genome Project and the subsequent -omic turn in the life science, is an interdisciplinary field of research. Qualitative work on the disciplinary identities of bioinformatic...