Exploring the Antifibrotic Mechanisms of Ghrelin: Modulating TGF-β Signaling in Organ Fibrosis [0.03%]
生长激素释放肽的抗纤维化机制：调控器官纤维化的TGF-β信号通路
Mei Li,Chang Zheng,Huiyi Wang et al.
Mei Li et al.
Exercise mediates noncoding RNAs in cardiovascular diseases: pathophysiological roles and clinical application [0.03%]
运动介导心血管疾病中的非编码RNA：病理生理作用及临床应用
Changyong Wu,Xiaocui Chen,Lu Yang et al.
Changyong Wu et al.
Radiation drives tertiary lymphoid structures to reshape TME for synergized antitumour immunity [0.03%]
辐射驱动三级淋巴组织重塑肿瘤微环境以协同抗肿瘤免疫反应
Shuling Li,Kuifei Chen,Zhenwei Sun et al.
Shuling Li et al.
Radiotherapy (RT) plays a key role in the tumour microenvironment (TME), impacting the immune response via cellular and humoral immunity. RT can induce local immunity to modify the TME. It can stimulate dendritic cell maturation and T-cell ...
Yangyang Lu,Rongjing Shi,Wenqin He et al.
Yangyang Lu et al.
Sjögren's syndrome (SS) is a chronic autoimmune disease caused by immune system disorders. The main clinical manifestations of SS are dry mouth and eyes caused by the destruction of exocrine glands, such as the salivary and lacrimal glands...
Epigenetic changes in patients with post-acute COVID-19 symptoms (PACS) and long-COVID: A systematic review [0.03%]
长期COVID和伴有急性后遗症的患者的表观基因变化：系统性综述
Madhura Shekhar Patil,Emma Richter,Lara Fanning et al.
Madhura Shekhar Patil et al.
Background: Up to 30% of people infected with SARS-CoV-2 report disabling symptoms 2 years after the infection. Over 100 persistent symptoms have been associated with Post-Acute COVID-19 Symptoms (PACS) and/or long-COVID,...
Advances in multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer starvation therapy [0.03%]
多功能金属有机框架(MOF)纳米平台在癌症饥饿疗法中的进展
Jinghan Cai,Yan Xu,Fei Liao
Jinghan Cai
Cancer remains a significant threat to human health today. Even though starvation therapy and other treatment methods have recently advanced to a new level of rapid development in tumour treatment, their limited therapeutic effectiveness an...
Thrombocytopenia in dengue infection: mechanisms and a potential application [0.03%]
登革感染中的血小板减少症：机制和潜在应用
Ahmad Suhail Khazali,Waqiyuddin Hilmi Hadrawi,Fatimah Ibrahim et al.
Ahmad Suhail Khazali et al.
Thrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms. Understanding the molecular events of this condition during d...
Epitranscriptomics and cervical cancer: the emerging role of m6A, m5C and m1A RNA modifications [0.03%]
表观转录组学与宫颈癌：m6A、m5C和m1A RNA修饰的作用机制及研究进展
Akshat D Modi,Hira Zahid,Ashlyn Chase Southerland et al.
Akshat D Modi et al.
Cervical cancer (CC), one of the most prevalent and detrimental gynaecologic cancers, evolves through genetic and epigenetic alterations resulting in the promotion of oncogenic activity and dysfunction of tumour-suppressing mechanisms. Desp...
ADP-ribose hydrolases: biological functions and potential therapeutic targets [0.03%]
烟酰胺腺嘌呤二核苷酸（还原型）水解酶的生物学功能及其作为潜在治疗靶点的可能性
Jingpeng Wang,Zhao-Qi Wang,Wen Zong
Jingpeng Wang
ADP-ribosylation (ADPRylation), which encompasses poly(ADP-ribosyl)ation and mono(ADP-ribosyl)ation, is an important post-translational modification catalysed by the poly(ADP-ribose) polymerase (PARP) enzyme superfamily. The process involve...
Mechanism and application of immune interventions in intracerebral haemorrhage [0.03%]
免疫干预在脑出血中的机制及应用研究进展
Xiaoxiao Xu,Yuanwei Li,Shiling Chen et al.
Xiaoxiao Xu et al.
Despite stroke being one of the major and increasing burdens to global health, therapeutic interventions in intracerebral haemorrhage (ICH) continue to be a challenge. Existing treatment methods, such as surgery and conservative treatment h...