NF- κ B: a mediator that promotes or inhibits angiogenesis in human diseases? [0.03%]
NF-κB：在人类疾病中促进或抑制血管生成的介质？
Yijing Jiang,Jie Zhang,Conglin Shi et al.
Yijing Jiang et al.
The nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB) signaling pathway, which is conserved in invertebrates, plays a significant role in human diseases such as inflammation-related diseases and carcinogenesis. Angioge...
microRNA pathological mechanisms between Parkinson's disease, Alzheimer's disease, glaucoma and macular degeneration [0.03%]
微RNA在帕金森病、阿尔茨海默病、青光眼和黄斑变性等疾病中的病理机制
Hsiuying Wang
Hsiuying Wang
Reactive oxygen species (ROS) play an essential role in regulating various functions of organisms such as gene transcription, signalling transduction and immune response. However, overproduction of ROS can lead to oxidative stress, which is...
Cigdem Kahraman,Duygu Kaya Bilecenoglu,Suna Sabuncuoglu et al.
Cigdem Kahraman et al.
Aging is the most prominent risk factor for many diseases, which is considered to be a complicated biological process. The rate of aging depends on the effectiveness of important mechanisms such as the protection of DNA from free radicals, ...
Inflammasomes in breast cancer: the ignition spark of progression and resistance? [0.03%]
炎性小体与乳腺癌进展和耐药的关系：点燃的火花？
Sawsan Elgohary,Hend M El Tayebi
Sawsan Elgohary
Inflammation and immune evasion are major key players in breast cancer (BC) progression. Recently, the FDA approved the use of anti-programmed death-ligand 1 antibody (anti-PD-L1) and phosphoinositide 3-kinase (PI3K) inhibitors against aggr...
Wnt/ β-catenin signalling pathway in breast cancer cells and its effect on reversing tumour drug resistance by alkaloids extracted from traditional Chinese medicine [0.03%]
乳腺癌细胞中Wnt/β-连环蛋白信号转导途径及其逆转肿瘤耐药性的研究：中药有效成分的影响
Xin-Lei Wu,Shen-Guo Lin,Yi-Wen Mao et al.
Xin-Lei Wu et al.
Breast cancer is a high-risk disease with a high mortality rate among women. Chemotherapy plays an important role in the treatment of breast cancer. However, chemotherapy eventually results in tumours that are resistant to drugs. In recent ...
Helicobacter pylori virulence factors: subversion of host immune system and development of various clinical outcomes [0.03%]
幽门螺杆菌毒力因子：逃避宿主免疫系统并发展出各种临床结局
Roghayeh Mohammadzadeh,Shaho Menbari,Abbas Pishdadian et al.
Roghayeh Mohammadzadeh et al.
Helicobacter pylori (H. pylori) is a worldwide spread bacterium, co-evolving with humans for at least 100 000 years. Despite the uncertainty about the mode of H. pylori transmission, the development of intra-gastric and extra-gastric diseas...
Dysregulated phosphate metabolism in autism spectrum disorder: associations and insights for future research [0.03%]
自闭症谱系障碍中的失调的磷代谢：关联和对未来研究的启示
Ronald B Brown
Ronald B Brown
Studies of autism spectrum disorder (ASD) related to exposure to toxic levels of dietary phosphate are lacking. Phosphate toxicity from dysregulated phosphate metabolism can negatively impact almost every major organ system of the body, inc...
Dual role of glycans and binding receptors in pathogenesis of enveloped viruses (by mainly focusing on two recent pandemics) [0.03%]
糖类和结合受体在有包膜病毒发病机制中的双重作用(主要针对最近的两次大流行病)
Fatemeh Pourrajab,Mohamad Reza Zare-Khormizi
Fatemeh Pourrajab
A period of about a decade has been estimated to pass for the emergence of a new infectious strain of a virus that may lead to the occurrence of a pandemic one. It is now suggested that the variants of the 1918 H1N1 and coronavirus disease-...
New perspective on DNA response pathway (DDR) in glioblastoma, focus on classic biomarkers and emerging roles of ncRNAs [0.03%]
胶质母细胞瘤DNA损伤反应通路的新视角：经典生物标志物及ncRNA的新兴作用机制聚焦
Bianca Oana Pirlog,Silvina Ilut,Radu Pirlog et al.
Bianca Oana Pirlog et al.
Background: Glioblastoma (GBM) is the most frequent type of primary brain cancer, having a median survival of only 15 months. The current standard of care includes a combination of surgery, radiotherapy (RT) and chemother...
Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia [0.03%]
急性白血病中靶向N-钙黏蛋白（CDH2）和恶性骨髓微环境
Jessica Parker,Sean Hockney,Orest W Blaschuk et al.
Jessica Parker et al.
This review discusses current research on acute paediatric leukaemia, the leukaemic bone marrow (BM) microenvironment and recently discovered therapeutic opportunities to target leukaemia-niche interactions. The tumour microenvironment play...