Poliovirus vaccination: current understanding of poliovirus interactions in humans and implications for the eradication of poliomyelitis [0.03%]
脊髓灰质炎病毒疫苗：人类脊髓灰质炎病毒感染的现状及消灭脊髓灰质炎的意义
P D Minor
P D Minor
Poliomyelitis is a paralytic disease of the motor neurones of the central nervous system, which is caused by poliovirus. The virus is transmitted by the faecal-oral route, and if virus replication is confined to the gut, it is harmless. Pol...
M A Brown,E L Duncan
M A Brown
Osteoporosis is a common condition of men and women, which is characterised by an increase in bone fragility due to a reduction in the amount of bone tissue. Predisposition to osteoporosis is largely genetically determined, and it is likely...
Clinical relevance of the molecular mechanisms of resistance to anti-cancer drugs [0.03%]
抗癌药物耐药性的分子机制的临床意义
M Links,R Brown
M Links
Resistance to anti-cancer drugs (drug resistance) can be defined in the laboratory by the amount of anti-cancer drug that is required to produce a given level of cell death (drug response). Clinical drug resistance can be defined either as ...
HLA-B27 and disease pathogenesis: new structural and functional insights [0.03%]
HLA-B27与疾病发病机制：新的结构和功能见解
P Bowness,N Zaccai,L Bird et al.
P Bowness et al.
The human leukocyte antigen class I allele HLA-B27 is a major histocompatibility complex (MHC) antigen that is strongly associated with the spondyloarthritic group of human rheumatic diseases, the most common of which is ankylosing spondyli...
L Bate,M Gardiner
L Bate
The term epilepsy encompasses a heterogeneous group of disorders, with a lifetime cumulative incidence of 3%. Genetic factors are thought to contribute to the aetiology in up to 60% of cases. Various molecular and cellular mechanisms give r...
G Van Zant,G de Haan
G Van Zant
The premise that there are genes that wield a strong influence on longevity has, until recently, not been a popular one and there has been no concerted effort to find such genes. However, the finding that single genes can have large effects...