J K Hickling
J K Hickling
lymphocytes (T cells) play critical roles in the regulation of immune responses, and are responsible for mediating many of the effector mechanisms of the immune system. For this reason, there has always been a need for assays to measure acc...
D J Carucci,M J Gardner,H Tettelin et al.
D J Carucci et al.
An international consortium of genome centres, advanced development teams and funding agencies has begun the task of sequencing the genome of the parasite Plasmodium falciparum, the most important cause of human malaria. Sequencing is proce...
Human cellular immune responses against human papillomaviruses in cervical neoplasia [0.03%]
宫颈肿瘤中人乳头瘤病毒的人体细胞免疫反应
S Man
S Man
Human papillomaviruses (HPVs) are ubiquitous DNA viruses that infect cutaneous and mucosal epithelia. A subset of HPVs infects the female genital tract, to induce cervical lesions that can progress to malignancy in some women. DNA from HPVs...
Clinical disease, immunity and protection against Plasmodium falciparum malaria in populations living in endemic areas [0.03%]
居住在流行区的人群罹患疟疾、免疫力和对恶性疟的保护作用
L Hviid
L Hviid
Malaria remains one of the biggest health problems in large parts of the world. In sub-Saharan Africa alone, it is currently estimated that there are more than 150 million clinical cases annually, and that about 2 million people die from th...
Human herpesvirus 6 [0.03%]
人疱疹病毒6型
S Dewhurst,D Skrincosky,N van Loon
S Dewhurst
Human herpesvirus 6 (HHV-6) is a T-lymphotropic herpesvirus, which infects almost all children by the age of two years and persists lifelong. Two distinct variants of HHV-6, HHV-6A and HHV-6B, have been described, and the latter has been sh...
Human herpesvirus 7 [0.03%]
人疱疹病毒7型
S Dewhurst,D Skrincosky,N van Loon
S Dewhurst
Human herpesvirus 7 (HHV-7) is a recently described T-lymphotropic herpesvirus, which infects almost all children by the age of three years and persists lifelong, with the shedding of infectious virus in saliva. HHV-7 is similar to human he...
C M Sanderson,G L Smith
C M Sanderson
Viruses replicate inside host cells, where they use host biochemical and structural components to facilitate the production of new virus particles. As a consequence of co-evolution with their hosts, viruses have acquired host genes and gene...
Structure-function analysis and the molecular origins of anti-DNA antibodies in systemic lupus erythematosus [0.03%]
结构功能分析和系统性红斑狼疮中抗DNA抗体的分子起源
J Kalsi,C T Ravirajan,A Rahman et al.
J Kalsi et al.
Patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE or 'lupus') develop a wide variety of clinical and serological manifestations including the presence of antibodies to double-stranded DNA (dsDNA), which are of...
P D Pharoah,C Caldas
P D Pharoah
The past 20 years have seen rapid advances in the understanding of the biology of human cancers, and a large body of evidence now supports the idea that accumulated genetic changes underlie the development of neoplasia. In this article, we ...
K J Wood,J Fry
K J Wood
Gene therapy continues to offer much hope for the future treatment of a variety of clinical conditions. The development of tailored, novel gene transfer vectors will improve the efficiency and stability of therapeutic gene expression in the...