YiLiu Wei,Xiaohan Ren,Zhitao Yuan et al.
YiLiu Wei et al.
Trauma is a significant health issue that not only leads to immediate death in many cases but also causes severe complications, such as sepsis, thrombosis, haemorrhage, acute respiratory distress syndrome and traumatic brain injury, among t...
Regorafenib and glioblastoma: a literature review of preclinical studies, molecular mechanisms and clinical effectiveness [0.03%]
瑞戈非尼与胶质母细胞瘤：一项关于基础研究、分子机制及临床疗效的文献回顾
Maria Patrizia Mongiardi,Roberto Pallini,Quintino Giorgio D&#x;Alessandris et al.
Maria Patrizia Mongiardi et al.
Glioblastoma IDH wild type (GBM) is a very aggressive brain tumour, characterised by an infiltrative growth pattern and by a prominent neoangiogenesis. Its prognosis is unfortunately dismal, and the median overall survival of GBM patients i...
Lauren C Frazer,Yukihiro Yamaguchi,Dhirendra K Singh et al.
Lauren C Frazer et al.
Epigenetic modifications, such as DNA methylation, are enzymatically regulated processes that directly impact gene expression patterns. In early life, they are central to developmental programming and have also been implicated in regulating...
Xiaona Zhan,Yi Yang,Qing Li et al.
Xiaona Zhan et al.
Deubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin chains attached to substrate proteins, preventing the substrate protein from being degraded by the ubiquitin-proteasome system. Deubiquit...
Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology [0.03%]
药理基因组学和表观基因组学方法来破解肿瘤学中IL-10阻断的谜团
Noha M Elemam,Radwa Y Mekky,Gowhar Rashid et al.
Noha M Elemam et al.
The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion and metastasis. T...
Guoheng Mo,Xinyu Lu,Sha Wu et al.
Guoheng Mo et al.
Manipulation of T cells has revolutionized cancer immunotherapy. Notably, the use of T cells carrying engineered T cell receptors (TCR-T) offers a favourable therapeutic pathway, particularly in the treatment of solid tumours. However, majo...
Live birth rate of gonadotropin-releasing hormone antagonist versus luteal phase gonadotropin-releasing hormone agonist protocol in IVF/ICSI: a systematic review and meta-analysis [0.03%]
促性腺激素释放激素类似物与黄体期激动剂方案在IVF/ICSI中活产率的系统评价和meta分析
Chenhong Liu,Tian Tian,Yanru Lou et al.
Chenhong Liu et al.
In vitro fertilization (IVF) and embryo transfer and intracytoplasmic sperm injection (ICSI) have allowed millions of infertile couples to achieve pregnancy. As an essential part of IVF/ICSI enabling the retrieval of a high number of oocyte...
Molecular mechanisms of action of negative pressure wound therapy: a systematic review [0.03%]
负压伤口治疗的作用机制：系统综述
Bharadhwaj Ravindhran,Nicole Schafer,Annabel Howitt et al.
Bharadhwaj Ravindhran et al.
Negative pressure wound therapy (NPWT) has significantly advanced wound care and continues to find new applications. Its effects at a molecular level however, remain a subject of debate. The aim of this systematic review is to summarize the...
Evaluation of prostate cancer tissue metabolomics: would clinics utilise it for diagnosis? [0.03%]
前列腺癌组织代谢组学的评估：临床会将其用于诊断吗？
Navneeta Bansal,Manoj Kumar,Satya N Sankhwar et al.
Navneeta Bansal et al.
The difficulty of diagnosing prostate cancer (PC) with the available biomarkers frequently leads to over-diagnosis and overtreatment of PC, underscoring the need for novel molecular signatures. The purpose of this review is to provide a sum...
A systematic review on antimicrobial activities of green synthesised Selaginella silver nanoparticles [0.03%]
关于绿合成的卷柏银纳米颗粒抗菌活性的系统评价研究论文
Khushbu Wadhwa,Hardeep Kaur,Neha Kapoor et al.
Khushbu Wadhwa et al.
Background: Metallic nanoparticles from different natural sources exhibit superior therapeutic options as compared to the conventional methods. Selaginella species have attracted special attention of researchers worldwide...