Chew-Wun Wu,Chin-Wen Chi,Wen-chang Lin
Chew-Wun Wu
Carcinoma of the stomach is one of the most prevalent cancer types in the world today. Only a limited number of biomarkers are available for detection and prognostic evaluation of gastric cancer. New advances in identifying molecular biomar...
Andra M Macedo,Riva P Oliveira,Srgio D J Pena
Andra M Macedo
Chagas disease, caused by the parasite protozoan Trypanosoma cruzi, is characterised by a variable clinical course, from symptomless cases to severe chronic disease with cardiac and/or gastrointestinal involvement. This variability has been...
G Strathdee,R Brown
G Strathdee
DNA methylation, the addition of a methyl group to the carbon-5 position of cytosine residues, is the only common covalent modification of human DNA and occurs almost exclusively at cytosines that are followed immediately by a guanine (so-c...
Manipulation of dendritic cells as an approach to improved outcomes in transplantation [0.03%]
操控树突状细胞以改善移植预后的尝试
P Toby H Coates,Bridget L Colvin,Holger Hackstein et al.
P Toby H Coates et al.
At the time of organ transplantation, a variety of non-parenchymal cells are transplanted simultaneously with the allograft. Recognition of the importance of these cells as potential immunostimulatory cells lead to the concept of 'passenger...
Sphingolipid signalling: molecular basis and role in TNF-alpha-induced cell death [0.03%]
鞘脂信号转导：分子基础及其在TNF-α诱导的细胞死亡中的作用
Sophie Malagarie-Cazenave,Nathalie Andrieu-Abadie,Bruno Ségui et al.
Sophie Malagarie-Cazenave et al.
Various lipidic molecules serve as second messengers for transducing signals from the cell surface to the cell interior and trigger specific cellular responses. Sphingolipids represent a complex group of lipids that have recently emerged as...
Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases [0.03%]
脂筏结构、功能及其在HIV、阿尔茨海默病和朊病毒疾病中的作用
Jacques Fantini,Nicolas Garmy,Radhia Mahfoud et al.
Jacques Fantini et al.
The fluid mosaic model of the plasma membrane has evolved considerably since its original formulation 30 years ago. Membrane lipids do not form a homogeneous phase consisting of glycerophospholipids (GPLs) and cholesterol, but a mosaic of d...
Why does inflammation persist: a dominant role for the stromal microenvironment? [0.03%]
为什么炎症会持续存在？基质微环境起主导作用？
Michael R Douglas,Karen E Morrison,Michael Salmon et al.
Michael R Douglas et al.
Inflammatory responses occur within tissue microenvironments, with functional contributions from both haematopoietic (lymphocytic) cells and stromal cells (including macrophages and fibroblasts). These environments are complex--a compound o...
Pre- and early postnatal nongenetic determinants of type 2 diabetes [0.03%]
影响2型糖尿病的 prenatal和早期postnatal非遗传因素
Susan E Ozanne,C Nick Hales
Susan E Ozanne
Epidemiological studies have revealed strong and internationally reproducible links between early growth restriction and subsequent risk of developing type 2 diabetes and the metabolic syndrome (glucose intolerance, hypertension and hypertr...
Patricia F Lalor,David H Adams
Patricia F Lalor
The liver is constantly exposed to gut-derived antigens that enter via the portal vein, and it must modulate immune responses so that harmful pathogens are cleared but necessary food antigens are ignored. The liver contains a large resident...
Kornelia Polyak
Kornelia Polyak
Many important advances have been made in the past decade in understanding breast cancer at the molecular level, and two important high-penetrance breast cancer genes--BRCA1 and BRCA2--have been identified. However, germline mutations in th...