Xiaoli Shen,Christian De Geyter,Hong Zhang et al.
Xiaoli Shen et al.
Correct placental development and function are critical to both the mother's and the foetus' health during pregnancy. Placental function depends on the correct development of the vascular network, which requires proper angiogenesis. Impaire...
Precision oncology using ex vivo technology: a step towards individualised cancer care? [0.03%]
利用体外技术进行精准肿瘤治疗：迈向个体化癌症治疗的一步？
Sophie T Williams,Greg Wells,Samantha Conroy et al.
Sophie T Williams et al.
Despite advances in cancer genomics and the increased use of genomic medicine, metastatic cancer is still mostly an incurable and fatal disease. With diminishing returns from traditional drug discovery strategies, and high clinical failure ...
The compartmentalised nature of neuronal mitophagy: molecular insights and implications [0.03%]
神经元线粒体自噬的分区特性：分子机制及意义
Fivos Borbolis,Konstantinos Palikaras
Fivos Borbolis
The maintenance of a healthy mitochondrial network and the ability to adjust organelle population in response to internal or external stimuli are essential for the function and the survival of eukaryotic cells. Over the last two decades sev...
Roles of CCR10/CCL27-CCL28 axis in tumour development: mechanisms, diagnostic and therapeutic approaches, and perspectives [0.03%]
CCR10/CCL27-CCL28轴在肿瘤发生发展中的作用：机制、诊断和治疗策略及展望
Ermias Mergia Terefe,Maria Jade Catalan Opulencia,Amir Rakhshani et al.
Ermias Mergia Terefe et al.
Cancer is now one of the major causes of death across the globe. The imbalance of cytokine and chemokine secretion has been reported to be involved in cancer development. Meanwhile, CC chemokines have received considerable interest in cance...
Blanca González-Bermúdez,Aldo Abarca-Ortega,Mónica González-Sánchez et al.
Blanca González-Bermúdez et al.
Ageing is interrelated with the development of immunosenescence. This article focuses on one of the cell sets of the adaptive immune system, T cells, and provides a review of the known changes in T cells associated with ageing. Such fundame...
Glycerol-3-phosphate acyltransferases and metabolic syndrome: recent advances and future perspectives [0.03%]
甘油-3-磷酸酰基转移酶与代谢综合征：最新研究进展和未来展望
Yinqiong Huang,Keyue Hu,Shu Lin et al.
Yinqiong Huang et al.
Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membran...
Unveil the pain of endometriosis: from the perspective of the nervous system [0.03%]
从神经系统角度揭开子宫内膜异位症的痛苦真相
Peiya Fan,Tian Li
Peiya Fan
Endometriosis is a chronic inflammatory disease with pelvic pain and uncharacteristic accompanying symptoms. Endometriosis-associated pain often persists despite treatment of the disease, thus it brings a deleterious impact on their persona...
Mismatch repair is a double-edged sword in the battle against microsatellite instability [0.03%]
错配修复在微卫星不稳定战役中是一把双刃剑
Carson J Miller,Karen Usdin
Carson J Miller
Roughly 3% of the human genome consists of microsatellites or tracts of short tandem repeats (STRs). These STRs are often unstable, undergoing high-frequency expansions (increases) or contractions (decreases) in the number of repeat units. ...
The emerging role of NOTCH3 receptor signalling in human lung diseases [0.03%]
NOTCH3受体信号通路在人类肺部疾病中作用的初步探索
Manish Bodas,Bharathiraja Subramaniyan,Harry Karmouty-Quintana et al.
Manish Bodas et al.
The mammalian respiratory system or lung is a tree-like branching structure, and the main site of gas exchange with the external environment. Structurally, the lung is broadly classified into the proximal (or conducting) airways and the dis...
Alessandra Bettiol,Silvia Galora,Flavia Rita Argento et al.
Alessandra Bettiol et al.
Thrombosis is a common disorder with a relevant burden of morbidity and mortality worldwide, particularly among elderly patients. Growing evidence demonstrated a direct role of oxidative stress in thrombosis, with various cell types contrib...