Deciphering Freezing of Gait: What Neuropathology Reveals About an Episodic Phenomenon [0.03%]
解密冻结发作：神经病理学揭示的阵发性现象
Gabor G Kovacs
Gabor G Kovacs
Freezing of gait (FoG) is an episodic, debilitating motor phenomenon defined as paroxysmal episodes wherein there is an inability to step effectively, despite attempting to do so. Although FoG is most commonly associated with Parkinson's di...
Cannabidiol Limits Early Aβ-Induced Glial Activation and Preserves Synaptic Integrity in Primary Mouse Hippocampal Neuron-Glia Cultures [0.03%]
大麻二酚限制Aβ引起的早期胶质细胞活化并保护原代鼠海马神经元-胶质共培养中突触的完整性
Karen Del Carmen Barboza Salgado,Ana Luiza Sciandretti de Albuquerque,Tamiles Caroline Fernandes Pedrosa et al.
Karen Del Carmen Barboza Salgado et al.
Alzheimer's disease (AD) initiates with subtle neuroimmune alterations that precede overt synaptic loss and neuronal death, yet the early sequence linking Aβ exposure to glial activation remains incompletely understood. To capture early ne...
Sex-Dependent Effects of CSF1R-Mediated Myeloid Cell Depletion in a Mouse Model of Multiple System Atrophy [0.03%]
在多系统萎缩小鼠模型中CSF1R介导的髓系细胞耗竭的性别差异效应
Kristina Battis,Michael Mante,Isabel Naumann et al.
Kristina Battis et al.
Sex-dependent differences in neurodegenerative disorders are becoming increasingly relevant in diagnosis and development of therapeutic targets. Although multiple system atrophy (MSA), a devastating and rapidly progressing atypical parkinso...
Shaghayegh Omidvar,Kenneth Campbell,Claude Alain et al.
Shaghayegh Omidvar et al.
The presentation of a rarely occurring auditory stimulus that contains a silent interval (or gap) among a sequence of frequently occurring stimuli that do not contain a gap can elicit a negative-going event-related potential known as the de...
Tackling Anxiety- and Stress-Related Freezing of Gait in People With Parkinson's Disease (TACKLING-FOG): Study Protocol for a Randomized Controlled Trial [0.03%]
应对焦虑和压力引起的帕金森病患者的冻结步态研究方案：一项随机对照试验(TACKLING-FOG)
Gijs Vissers,Anouk Tosserams,Annelien A Duits et al.
Gijs Vissers et al.
Freezing of gait (FOG) is a common and disabling symptom in people with Parkinson's Disease (PD), characterized by paroxysmal episodes where there is an inability to step effectively, despite attempting to do so. Anxiety and stress exacerba...
Experiences of Anxiety and Its Relationship to Freezing of Gait in Parkinson's Disease: A Qualitative Study [0.03%]
帕金森病患者焦虑体验及与冻结步态关系的定性研究
Gijs Vissers,William R Young,Jorik Nonnekes
Gijs Vissers
Freezing of gait (FOG) is a disabling motor symptom in Parkinson's disease (PD) with substantial impact on mobility and quality of life. Anxiety is frequently implicated in triggering or worsening FOG, yet the lived experience of this inter...
Giovanni M Di Liberto,Emily Y J Ip
Giovanni M Di Liberto
Understanding the neural basis of speech communication is essential for uncovering how sounds are translated into meaning, how that changes with development, ageing and speech-related deficits, as well as contributing to brain-computer inte...
Multifiber Array-Based Photometry System for Multiregional Functional Mapping in the Mouse Brain [0.03%]
用于小鼠大脑多区域功能定位的多功能光纤阵列光度系统
Manil Bradai,Mirna Merkler,Gabriela Gil et al.
Manil Bradai et al.
Mesoscopic functional brain mapping is essential for a better understanding of various brain functions and dysfunctions. However, accessing distributed neural circuits in mammalian brain regions remains a significant challenge. While fiber ...
Rapid Multimuscle Cortical Mapping of the Upper Limb: Activity Reveals Intralimb Gradients [0.03%]
快速的大脑皮层上肢多重肌肉定位(mapping):活动显示了肢内梯度(gradients)
Rowan Boyles,Napat Kiatwongwanich,Mikal Vicente et al.
Rowan Boyles et al.
Transcranial magnetic stimulation (TMS) mapping provides valuable insight into corticospinal organisation and plasticity, but conventional protocols are often too time-consuming to be practical in clinical settings. This study aimed to refi...