Comparing tonic and phasic dendritic calcium in cholinergic pedunculopontine neurons and dopaminergic substantia nigra neurons [0.03%]
胆碱能被盖桥脑核神经元和多巴胺黑质神经元的簇状和棘状树突钙离子的比较研究
Rita Yu-Tzu Chen,Rebekah C Evans
Rita Yu-Tzu Chen
Several brainstem nuclei degenerate in Parkinson's disease (PD). In addition to the well-characterized dopaminergic neurons of the substantia nigra pars compacta (SNc), the cholinergic neurons of the pedunculopontine nucleus (PPN) also dege...
Microglia cells treated with synthetic vasoactive intestinal peptide or transduced with LentiVIP protect neuronal cells against degeneration [0.03%]
用合成血管活性肠肽处理的少突胶质细胞或转染LentiVIP的少突胶质细胞可保护神经细胞免受退化损伤
Azize Yasemin Goksu,Fatma Gonca Kocanci,Ersin Akinci et al.
Azize Yasemin Goksu et al.
A common pathological hallmark of neurodegenerative disorders is neuronal cell death, accompanied by neuroinflammation and oxidative stress. The vasoactive intestinal peptide (VIP) is a pleiotropic peptide that combines neuroprotective and ...
The role of the genetic influence of DRD4 in Chinese adults in the context of the choice of tourist attractions [0.03%]
DRD4基因遗传影响在中国成年人选择旅游景点中的作用研究
Ze Geng Chen,Shi Min Fu
Ze Geng Chen
The aim of this work was to analyse the effect of tandem repetitions in exon III of the DRD4 gene on the features of human decision-making in a model of choosing tourist attractions by adult residents of China. The study included 380 subjec...
An exploratory research report on brain mineralization in postoperative delirium and cognitive decline [0.03%]
术后谵妄和认知功能下降的脑内矿物质沉积水平探索性研究报告
Florian Lammers-Lietz,Friedrich Borchers,Insa Feinkohl et al.
Florian Lammers-Lietz et al.
Delirium is a severe postoperative complication associated with poor overall and especially neurocognitive prognosis. Altered brain mineralization is found in neurodegenerative disorders but has not been studied in postoperative delirium an...
How close are we to a breakthrough? The hunt for blood biomarkers in Parkinson's disease diagnosis [0.03%]
我们离突破还有多远？帕金森病诊断中血液生物标志物的寻找之旅
Cheng Liu,Yang Su,Xiaolong Ma et al.
Cheng Liu et al.
Parkinson's disease (PD), being the second largest neurodegenerative disease, poses challenges in early detection, resulting in a lack of timely treatment options to effectively manage the disease. By the time clinical diagnosis becomes pos...
Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint [0.03%]
大鼠大脑谷氨酸突触的丰富环境的快速形成：代谢塑料指纹
Nicholas Pintori,Alessandro Piva,Francesca Mottarlini et al.
Nicholas Pintori et al.
Environmental enrichment (EE) has been shown to produce beneficial effects in addiction disorders; however, due to its configurational complexity, the underlying mechanisms are not yet fully elucidated. Recent evidence suggests that EE, act...
A systematic review on the application of machine learning models in psychometric questionnaires for the diagnosis of attention deficit hyperactivity disorder [0.03%]
机器学习模型在注意力缺陷多动障碍心理测量问卷诊断中的应用系统综述
Lucía Caselles-Pina,Alejandro Quesada-López,Aaron Sújar et al.
Lucía Caselles-Pina et al.
Attention deficit hyperactivity disorder is one of the most prevalent neurodevelopmental disorders worldwide. Recent studies show that machine learning has great potential for the diagnosis of attention deficit hyperactivity disorder. The a...
Dopamine activity in the nigrostriatal pathway alters cue-induced risky choice patterns in female rats [0.03%]
黑质纹状体通路的多巴胺活动改变雌性大鼠的风险选择模式中的诱因诱导反应
Brett A Hathaway,Andrew Li,Hannah G Brodie et al.
Brett A Hathaway et al.
Deficits in cost/benefit decision making is a critical risk factor for gambling disorder. Reward-paired cues may play an important role, as these stimuli can enhance risk preference in rats. Despite extensive research implicating the dorsal...
Sodium nitroprusside enhances stepping test performance and increases medium spiny neurons responsiveness to cortical inputs in a rat model of Levodopa-induced dyskinesias [0.03%]
硝普钠提高步进测试表现和增加多巴胺诱导的异常运动的大鼠模型中皮层输入的中脊神经元反应性
Danilo Leandro Ribeiro,Rayanne Poletti Guimarães,Keila Bariotto-Dos-Santos et al.
Danilo Leandro Ribeiro et al.
Levodopa (L-DOPA) is the classical gold standard treatment for Parkinson's disease. However, its chronic administration can lead to the development of L-DOPA-induced dyskinesias (LIDs). Dysregulation of the nitric oxide-cyclic guanosine mon...
Deficits in basal and evoked striatal dopamine release following alpha-synuclein preformed fibril injection: An in vivo microdialysis study [0.03%]
注射α-突触核蛋白预制纤维后基底和诱发的纹状体多巴胺释放缺陷：一项体内微透析研究
Ashley Centner,Isabella Del Priore,Nicole Chambers et al.
Ashley Centner et al.
Parkinson's disease (PD) is characterized by the accumulation of misfolded alpha-synuclein (α-syn) protein, forming intraneuronal Lewy body (LB) inclusions. The α-syn preformed fibril (PFF) model of PD recapitulates α-syn aggregation, pr...