Usefulness of guideline recommendations for prognosis in patients with candidemia [0.03%]
卡血症患者诊疗指南中预后推荐的价值评估
Guillermo Cuervo,Carolina Garcia-Vidal,Mireia Puig-Asensio et al.
Guillermo Cuervo et al.
We aimed to analyze whether the lack of inclusion of specific recommendations for the management of candidemia is an independent risk factor for early and overall mortality. Multicenter study of adult patients with candidemia in 13 hospital...
Multicenter Study
Medical mycology. 2019 Aug 1;57(6):659-667. DOI:10.1093/mmy/myy118 2019
Understanding the microbiology of the Aspergillus cell wall and the efficacy of caspofungin [0.03%]
卡泊芬净疗效与曲霉细胞壁微生物学研究之关联
Cameron M Douglas
Cameron M Douglas
The efficacy of echinocandins against Aspergillus species has been established through in vitro assays, in animal models of infection, and in clinical practice. Caspofungin is an inhibitor of 1,3-β-D glucan synthesis (GS) that produces dra...
Amino acid acquisition, cross-pathway control, and virulence in Aspergillus [0.03%]
棒曲霉属氨基酸的获取、交叉途径调控和致病性
Gerhard H Braus,Christoph Sasse,Sven Krappmann
Gerhard H Braus
Supply of all amino acids required for translation is crucial for the synthesis of new proteins. Fungal amino acid biosynthesis has to be coordinated with amino acid uptake as well as protein degradation. A global regulator that connects am...
G A Payne,W C Nierman,J R Wortman et al.
G A Payne et al.
Aspergillus flavus is a plant and animal pathogen that also produces the potent carcinogen aflatoxin. Aspergillus oryzae is a closely related species that has been used for centuries in the food fermentation industry and is Generally Regard...
G Turner,G J Allen,D Keszenman-Pereyra et al.
G Turner et al.
Products of essential genes of Aspergillus fumigatus are seen as potential targets for antifungal drugs, and both functional screens and bioinformatics approaches have been used to help identify such genes. The random screening approach mak...
Nancy Keller,Jinwoo Bok,Dawoon Chung et al.
Nancy Keller et al.
Several toxins have been implicated in Aspergillus fumigatus pathogenicity. Among these are gliotoxin, fumagillin, fumagatin, and helvolic acid. Recently we have identified a nuclear protein, LaeA, that regulates the production of all of th...
Koenraad H Vandewoude,Dirk Vogelaers,Stijn I Blot
Koenraad H Vandewoude
Invasive pulmonary aspergillosis (IPA) is a serious opportunistic infection mainly affecting seriously immunocompromised patients. The major risk factor is prolonged granulocytopenia. Most literature on the epidemiology and clinical impact ...
Genetic and respiratory tract risk factors for aspergillosis: ABPA and asthma with fungal sensitization [0.03%]
曲霉病的遗传和呼吸道危险因素：ABPA和真菌变应性哮喘
Alan P Knutsen
Alan P Knutsen
Allergic bronchopulmonary aspergillosis (ABPA) is a Th2 allergic hypersensitivity lung disease due to bronchial colonization of Aspergillus fumigatus that affects 1-2% of asthmatic and 7-9% of cystic fibrosis (CF) patients. We hypothesize t...
Aimee K Zaas
Aimee K Zaas
Invasive aspergillosis is a common and life-threatening infection in immunocompromised individuals. Epidemiologic risk factors do not fully explain susceptibility to disease amongst at-risk persons. Recently, the contribution of host geneti...
Medical mycology development and epidemiology in the USA, UK and Japan [0.03%]
美国、英国和日本的医学真菌学发展及流行病学
Aya Homei
Aya Homei
Medical mycology is a relatively young sub-discipline of medicine, institutionalized principally after the Second World War. In this paper, I will trace the process leading to the establishment of medical mycology in the United States, Unit...