The Glyco-Switch of life: O-GlcNAcylation in cell fate decision [0.03%]
生命之糖开关：O-GlcNAc酰化在细胞命运决定中的作用
Ao Wang,Matthew Young,Jiaoyang Jiang
Ao Wang
O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a unique type of protein glycosylation that intricately links cellular metabolism to various signaling pathways. This reversible, nutrient-sensitive modification dynamically regulat...
Yusen Zhou,Vishnu Ghosh,Shriramprasad Venkatesan et al.
Yusen Zhou et al.
The glycan distribution on cells is governed by the activities of different families of enzymes that are together called "glycoEnzymes." These include ~400 gene products or 2% of the proteome, that have recently been curated in an ontology ...
Nadine L Samara
Nadine L Samara
GalNAc-Ts are a large family of glycosyltransferases that regulate numerous cellular processes by initiating the post-translational modification mucin-type O-glycosylation. Disruptions in GalNAc-T expression and function are associated with...
Layilin at the Crossroads of Immunity and Motility: A C-type Lectin Receptor in Hyaluronan Signaling [0.03%]
介导免疫与运动的LAYILIN：透明质酸信号传导中的C型凝集素受体
Rebecca A Mellema,Aaron C Petrey
Rebecca A Mellema
Layilin, an understudied C-type lectin receptor for hyaluronan, was initially hypothesized to regulate cell motility due to its binding partner, talin. Subsequent studies identified layilin as a receptor for hyaluronan with roles in regulat...
Wenjun Wang,Valeriia Kuzyk,Guinevere S M Lageveen-Kammeijer et al.
Wenjun Wang et al.
Glycomics and glycoproteomics represent the systematic exploration of glycan structures and glycoprotein compositions within biological systems, aiming to elucidate their roles in physiological and pathological processes, including cancer, ...
Sialidases derived from Gardnerella vaginalis and Prevotella timonensis remodel the sperm glycocalyx and impair sperm function [0.03%]
阴道加德纳菌和蒂蒙拟杆菌来源的唾液酸酶重塑精子糖萼并损害精子功能
Sarah Dohadwala,Purna Shah,Maura K Farrell et al.
Sarah Dohadwala et al.
Bacterial vaginosis (BV), a dysbiosis of the vaginal microbiome, affects approximately 30% of women worldwide (up to 50% in some regions) and is associated with several adverse health outcomes including preterm birth and increased incidence...
Evaluation of β-1,3-Glucan Recognition Protein Binding to β-1,3-Glucan and β-1,3-Glucan/DNA Complexes [0.03%]
β-1,3-葡聚糖识别蛋白与β-1,3-葡聚糖及β-1,3-葡聚糖/DNA复合物的结合评价研究
Kazuki Sumiya,Kento Suzuki,Rui Tada et al.
Kazuki Sumiya et al.
Although the interaction between β-1,3-glucans (BG) and β-1,3-glucan recognition protein (BGRP) derived from insects is well established, the binding interaction and recognition mechanism of BG when complexed with deoxyadenosine (dA) or C...
Establishment of a method for measuring the 3-O-sulfated structure in heparan sulfate [0.03%]
建立硫酸肝素中3-O-磺酸结构的测定方法
Hideo Mochizuki,Yuya Otsuka,Koji Kimata
Hideo Mochizuki
Heparan sulfate is present on the cell surface and within the extracellular matrix of most animal species, and it regulates various physiological processes by binding to a wide variety of functional proteins. The diverse array of sulfation ...