JAAG: a JSON input file Assembler for AlphaFold 3 with Glycan integration [0.03%]
JAAG：具有糖蛋白集成的AlphaFold 3的JSON输入文件组装程序
Chin Huang,Kelley W Moremen
Chin Huang
Standalone AlphaFold 3 (AF3) models proteins, post-translational modifications, and ligands (including glycans) from a single JSON input file. Plausible glycan stereochemistry is more consistently achieved when monosaccharides are specified...
Crystal and Cryo-EM structure of PPL, a novel hexameric R-type lectin from the poisonous mushroom Pleurocybella porrigens [0.03%]
来自毒蘑菇 Pleurocybella porrigens 的新型六聚体 R 型凝集素 PPL 的晶体和冷冻电镜结构
Daisuke Adachi,Naito Ishimoto,Kenji Mizutani et al.
Daisuke Adachi et al.
Pleurocybella porrigens is a mushroom that grows widely around the temperate northern hemisphere, and was once considered edible, especially in Japan. Following a number of deaths in 2004, investigations revealed the presence of various tox...
Galectin-3 facilitates Helicobacter pylori-induced apoptosis independently of sensing lysosomal damage [0.03%]
乳果糖-3独立于溶酶体损伤感应促进幽门螺旋杆菌诱导的细胞凋亡
Yu-Hsien Hung,Fang-Yen Li,Huang-Yu Yang et al.
Yu-Hsien Hung et al.
Helicobacter pylori is a prevalent gastric pathogen that modulates host cell signaling pathways and represents a major risk factor for chronic gastritis, peptic ulcers, and gastric cancer. Galectin-3 is a host factor that contributes to imm...
Glycoregulation of E3(SCF) ubiquitin ligases in unicellular eukaryotes [0.03%]
单细胞真核生物中E3(SCF)泛素连接酶的糖基调节
Donovan A Cantrell,Hanke van der Wel,Christopher M West
Donovan A Cantrell
Skp1 is an essential adaptor within the Skp1/Cul1/F-box (SCF) class of E3 polyubiquitin ligases that regulate protein degradation in all eukaryotes. Skp1 is also a target of a 5-enzyme glycosylation pathway in parasites and other unicellula...
Meeting Report on the 1st GlyCosmos Symposium & Jamboree -Community-Driven Expansion of Glycan-Binding Molecules Resources [0.03%]
第一届GlyCosmos研讨会暨大会报告：社区驱动的糖蛋白结合分子资源拓展会议综述
Chiaki Nagai-Okatani,Masae Hosoda,Winnie Hsiung et al.
Chiaki Nagai-Okatani et al.
Short Mucin-Type O-Glycans in Cancer: Biomarker and Therapeutic Potential amid Analytical Barriers [0.03%]
癌症中的短黏蛋白O-糖链：分析障碍下的生物标志物和治疗潜力
Henrique Sousa,Inês A B Ribeiro,Marta Falcão et al.
Henrique Sousa et al.
Mucin-type O-glycans are abundant protein modifications that regulate cell signalling, adhesion, and immune interactions. In cancer, their biosynthetic pathways are frequently disrupted, leading to the accumulation of truncated structures, ...
Detecting Human Milk Oligosaccharides Through Enzymatic Replacement with Azido Fucose [0.03%]
通过酶促置换法用叠氮基岩藻糖检测人类乳寡糖
Zhengliang L Wu,Todd A Nauman,Shao-Yeh Lu et al.
Zhengliang L Wu et al.
Human milk oligosaccharides (HMOs) are complex sugars. These sugars possess prebiotic, antibiotic and immunomodulatory properties and therefore are important for the health and well-being of newborn babies. The backbones of HMOs are termina...
Ablation of CD22 Induces a Pro-Inflammatory Transcriptome Shift and Endocytic Deficits in M2-like Macrophages [0.03%]
CD22缺失诱导M2型巨噬细胞向促炎转录组转变并造成内吞缺陷
Emily N Kukan,Gabrielle L Fabiano,Julie Y Zhou et al.
Emily N Kukan et al.
The interactions between environmental glycans and glycan-binding proteins modulate a host of processes across biological systems. The Siglec/sialic acid axis has gained increasing attention as an immunologic checkpoint due to its involveme...
Glycoengineering the Pseudomonas exotoxin a for multi-sequon integration and enhanced bioconjugation efficiency by PglS [0.03%]
通过PglS对铜绿假单胞菌外毒素A进行糖工程改造以实现多序列整合和增强生物连接效率
Cory J Knoot,Nathan Pomper,Lloyd S Robinson et al.
Cory J Knoot et al.
Glycoconjugate vaccines, also known as polysaccharide protein conjugate vaccines, consist of bacterial polysaccharides covalently linked to immunogenic carrier proteins. Bioconjugate vaccines are a type of glycoconjugate produced by oligosa...